Journal ArticleDOI
Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2)
Jean Reignier,Julie Boisramé-Helms,L. Brisard,Jean-Baptiste Lascarrou,Ali Ait Hssain,Nadia Anguel,Laurent Argaud,Karim Asehnoune,Pierre Asfar,Frédéric Bellec,Vlad Botoc,Anne Bretagnol,Hoang-Nam Bui,Emmanuel Canet,Daniel da Silva,Michael Darmon,Vincent Das,Jérôme Devaquet,Michel Djibré,Frédérique Ganster,Maité Garrouste-Orgeas,Stéphane Gaudry,Olivier Gontier,Claude Guérin,Bertrand Guidet,Christophe Guitton,Jean-Etienne Herbrecht,Jean-Claude Lacherade,Philippe Letocart,Frédéric Martino,Virginie Maxime,Emmanuelle Mercier,Jean-Paul Mira,Saad Nseir,Gaël Piton,Jean-Pierre Quenot,Jack Richecoeur,Jean-Philippe Rigaud,René Robert,Nathalie Rolin,Carole Schwebel,Michel Sirodot,François Tinturier,Didier Thevenin,Bruno Giraudeau,Amélie Le Gouge,Amélie Le Gouge,Hervé Dupont,Marc Pierrot,François Beloncle,Danièle Combaux,Romain Mercier,Hadrien Winiszewski,Gilles Capellier,Gilles Hilbert,Didier Gruson,Pierre Kalfon,Bertrand Souweine,Elizabeth Coupez,Jean-Damien Ricard,Jonathan Messika,François Bougerol,Pierre-Louis Declercq,Auguste Dargent,Audrey Large,Djillali Annane,Bernard Clair,Agnès Bonadona,Rebecca Hamidfar,Christian Richard,Mathieu Henry-Lagarrigue,Ahiem Yehia Yehia,Johanna Temime,Stephanie Barrailler,Raphael Favory,Erika Parmentier-Decrucq,Mercé Jourdain,Loredana Baboi,Marie Simon,Thomas Baudry,Mehran Monchi,Jérôme Roustan,Patrick Bardou,Alice Cottereau,Philippe Guiot,Noelle Brule,Mickael Landais,Antoine Roquilly,Thierry Boulain,Dalila Benzekri,Benoit Champigneulle,Jalel Tahiri,Gabriel Preda,Benoit Misset,Virginie Lemiale,Lara Zafrani,Muriel Fartoukh,Guillaume Thiery,Delphine Chatellier,Rémi Coudroy,Renaud Chouquer,Christine Brasse,Arnaud Delahaye,Luís Carlos de Souza Ferreira,Régine Vermesch,Stéphanie Chevalier,Charlotte Quentin,Quentin Maestraggi,Francis Schneider,Ferhat Meziani,Charles Cerf,Grégoire Trebbia,Charlotte Salmon-Gandonnière,Laetitia Bodet-Contentin +113 more
TLDR
In critically ill adults with shock, early isocaloric enteral nutrition did not reduce mortality or the risk of secondary infections but was associated with a greater risk of digestive complications compared with early isocallyoric parenteral nutrition.About:
This article is published in The Lancet.The article was published on 2018-01-13. It has received 346 citations till now. The article focuses on the topics: Parenteral nutrition & Enteral administration.read more
Citations
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Journal ArticleDOI
Update on nutritional assessment and therapy in critical care
TL;DR: Based on recent studies, full energy feeding early during critical illness has no measurable beneficial effect, and may even be harmful, when applied to entire populations, and the mechanisms underlying this are unknown and remain proposed theories.
Journal ArticleDOI
Risks in Management of Enteral Nutrition in Intensive Care Units: A Literature Review and Narrative Synthesis.
Magdalena Hoffmann,Christine Maria Schwarz,Stefan Fürst,Christina Starchl,Elisabeth Lobmeyr,Gerald Sendlhofer,Marie-Madlen Jeitziner +6 more
TL;DR: In this article, a literature review was conducted to identify risks and safety issues for patient safety in the management of enteral nutrition in critically ill patients in the ICU, including inadequate tube management, missing energy target, missing a nutritionist, bad hygiene and handling, wrong time management and speed, nutritional interruptions, wrong body position, gastrointestinal complication and infections, missing or not using guidelines, understaffing, and lack of education.
Journal ArticleDOI
Should we calculate or measure energy expenditure? practical aspects in the ICU.
TL;DR: To minimize energy debt in the intensive care unit, this work supports early enteral feeding of critically ill patients and recommends that the supplemental parenteral nutrition should be prescribed to close the caloric gap if the goal is not reached by enteral nutrition alone.
Journal ArticleDOI
Gut dysmotility in the ICU: diagnosis and therapeutic options.
TL;DR: ‘Off-label’ metoclopramide and/or erythromycin administration are effective for upper gastrointestinal dysmotility but have adverse effects and trials of alternative or novel promotility drugs have not demonstrated superiority over current pharmacotherapies.
Journal ArticleDOI
Safety, Tolerability, and Outcomes of Enteral Nutrition in Extracorporeal Membrane Oxygenation.
TL;DR: A narrative review intends to provide an overview of ECMO, highlight the rationale for nutrition support in this population, and review the safety, tolerability, and outcomes associated with enteral nutrition during ECMO.
References
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The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.
Jean Louis Vincent,R. Moreno,Jukka Takala,Sheila Willatts,A. de Mendonça,Hajo A. Bruining,C. K. Reinhart,P. M. Suter,L. G. Thijs +8 more
TL;DR: The ESICM developed a so-called sepsis-related organ failure assessment (SOFA) score to describe quantitatively and as objectively as possible the degree of organ dysfunction/failure over time in groups of patients or even in individual patients.
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Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
Richard Peto,M.C. Pike,P. Armitage,N. E. Breslow,David Cox,S V Howard,N Mantel,Klim McPherson,Julian Peto,Pete Smith +9 more
TL;DR: Efficient methods of analysis of randomized clinical trials in which the authors wish to compare the duration of survival among different groups of patients are described.
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A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study
TL;DR: The SAPS II, based on a large international sample of patients, provides an estimate of the risk of death without having to specify a primary diagnosis, and is a starting point for future evaluation of the efficiency of intensive care units.
Journal ArticleDOI
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
Andrew Rhodes,Laura Evans,Waleed Alhazzani,Mitchell M. Levy,Massimo Antonelli,Ricard Ferrer,Anand Kumar,Jonathan E. Sevransky,Charles L. Sprung,Mark E. Nunnally,Bram Rochwerg,Gordon D. Rubenfeld,Derek C. Angus,Djillali Annane,Richard Beale,Geoffrey J. Bellinghan,Gordon R. Bernard,Jean Daniel Chiche,Craig M. Coopersmith,Daniel De Backer,Craig French,Seitaro Fujishima,Herwig Gerlach,Jorge Hidalgo,Steven M. Hollenberg,Alan E. Jones,Dilip R. Karnad,Ruth M. Kleinpell,Younsuck Koh,Thiago Lisboa,Flávia Ribeiro Machado,John J. Marini,John C. Marshall,John E. Mazuski,Lauralyn McIntyre,Anthony S. McLean,Sangeeta Mehta,Rui Moreno,John Myburgh,Paolo Navalesi,Osamu Nishida,Tiffany M. Osborn,Anders Perner,Colleen M. Plunkett,Marco Ranieri,Christa A. Schorr,Maureen A. Seckel,Christopher W. Seymour,Lisa Shieh,Khalid A. Shukri,Steven Q. Simpson,Mervyn Singer,B. Taylor Thompson,Sean R. Townsend,Thomas Van der Poll,Jean Louis Vincent,W. Joost Wiersinga,Janice L. Zimmerman,R. Phillip Dellinger +58 more
TL;DR: Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
Journal ArticleDOI
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design.
Richard Peto,M.C. Pike,P. Armitage,N. E. Breslow,David Cox,S V Howard,N Mantel,Klim McPherson,Julian Peto,Pete Smith +9 more
TL;DR: This report is the first simple account yet published for non-statistical physicians of how to analyse efficiently data from clinical trials of survival duration, and it may be preferable to use these statistical methods to study time to local recurrence of tumour, or toStudy time to detectable metastatic spread, in addition to studying total survival.
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