Journal ArticleDOI
Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2)
Jean Reignier,Julie Boisramé-Helms,L. Brisard,Jean-Baptiste Lascarrou,Ali Ait Hssain,Nadia Anguel,Laurent Argaud,Karim Asehnoune,Pierre Asfar,Frédéric Bellec,Vlad Botoc,Anne Bretagnol,Hoang-Nam Bui,Emmanuel Canet,Daniel da Silva,Michael Darmon,Vincent Das,Jérôme Devaquet,Michel Djibré,Frédérique Ganster,Maité Garrouste-Orgeas,Stéphane Gaudry,Olivier Gontier,Claude Guérin,Bertrand Guidet,Christophe Guitton,Jean-Etienne Herbrecht,Jean-Claude Lacherade,Philippe Letocart,Frédéric Martino,Virginie Maxime,Emmanuelle Mercier,Jean-Paul Mira,Saad Nseir,Gaël Piton,Jean-Pierre Quenot,Jack Richecoeur,Jean-Philippe Rigaud,René Robert,Nathalie Rolin,Carole Schwebel,Michel Sirodot,François Tinturier,Didier Thevenin,Bruno Giraudeau,Amélie Le Gouge,Amélie Le Gouge,Hervé Dupont,Marc Pierrot,François Beloncle,Danièle Combaux,Romain Mercier,Hadrien Winiszewski,Gilles Capellier,Gilles Hilbert,Didier Gruson,Pierre Kalfon,Bertrand Souweine,Elizabeth Coupez,Jean-Damien Ricard,Jonathan Messika,François Bougerol,Pierre-Louis Declercq,Auguste Dargent,Audrey Large,Djillali Annane,Bernard Clair,Agnès Bonadona,Rebecca Hamidfar,Christian Richard,Mathieu Henry-Lagarrigue,Ahiem Yehia Yehia,Johanna Temime,Stephanie Barrailler,Raphael Favory,Erika Parmentier-Decrucq,Mercé Jourdain,Loredana Baboi,Marie Simon,Thomas Baudry,Mehran Monchi,Jérôme Roustan,Patrick Bardou,Alice Cottereau,Philippe Guiot,Noelle Brule,Mickael Landais,Antoine Roquilly,Thierry Boulain,Dalila Benzekri,Benoit Champigneulle,Jalel Tahiri,Gabriel Preda,Benoit Misset,Virginie Lemiale,Lara Zafrani,Muriel Fartoukh,Guillaume Thiery,Delphine Chatellier,Rémi Coudroy,Renaud Chouquer,Christine Brasse,Arnaud Delahaye,Luís Carlos de Souza Ferreira,Régine Vermesch,Stéphanie Chevalier,Charlotte Quentin,Quentin Maestraggi,Francis Schneider,Ferhat Meziani,Charles Cerf,Grégoire Trebbia,Charlotte Salmon-Gandonnière,Laetitia Bodet-Contentin +113 more
TLDR
In critically ill adults with shock, early isocaloric enteral nutrition did not reduce mortality or the risk of secondary infections but was associated with a greater risk of digestive complications compared with early isocallyoric parenteral nutrition.About:
This article is published in The Lancet.The article was published on 2018-01-13. It has received 346 citations till now. The article focuses on the topics: Parenteral nutrition & Enteral administration.read more
Citations
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Journal ArticleDOI
Early versus delayed enteral nutrition in mechanically ventilated patients with circulatory shock: a nested cohort analysis of an international multicenter, pragmatic clinical trial
Luis Alfonso Ortiz-Reyes,Jayshil J. Patel,Xuran Jiang,Angel Coz Yataco,Andrew G. Day,Faraaz Ali Shah,J. Peter Zelten,Maximiliano Tamae-Kakazu,Todd W. Rice,Daren K. Heyland +9 more
TL;DR: In this paper , an international, multicenter, pragmatic randomized clinical trial (RCT) evaluating protein dose in ICU patients with circulatory shock was conducted, and the authors found that early enteral nutrition (EEN) was associated with improved clinical outcomes in mechanically ventilated (MV) patients.
Journal ArticleDOI
A systematic review of the definitions and prevalence of feeding intolerance in critically ill adults.
TL;DR: A systematic review of studies in adult critical care patients to evaluate the definitions, relative risk, predictors and clinical outcomes of enteral feeding intolerance (FI) and to propose a uniform definition was performed in this article .
Journal ArticleDOI
When and how to manage enteral feeding intolerance
TL;DR: The study found no difference between ulimorelin and metoclopramide in the primary endpoint of percentage of daily protein prescription over 5 days of treatment, and there were no differences in the secondary endpoints of feeding success, gastric emptying assessed by paracetamol absorption, incidence of recurrent EFI, vomiting or regurgitation, aspiration, and pulmonary infection.
Journal ArticleDOI
Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial
Jiajia Lin,Gordon S. Doig,Arthur R. H. van Zanten,Yang Wang,Zhongheng Zhang,Tao Chen,Lixin Zhou,Dong-po Jiang,Jiandong Lin,Yafeng Liang,Junli Sun,Wenming Liu,Zhen Yang,Rumin Zhang,An Zhang,Zhigang Zhou,Yang Liu,Fei Tong,Aijun Pan,Xiaobo Huang,Chuming Fan,Weihua Lu,Wei Li,Liming Gu,Yingguang Xie,Feng Guo,Lin Han,Lihua Zhou,Xiangde Zheng,Feng Shan,Yan Qu,Lian-di Li,Zhiqiang Zou,Yan Gao,Chunli Yang,Xijing Zhang,Jinglan Wu,Weixing Zhang,Yuan Zong,Bingyu Qin,Zhenhan Zhai,Ping Chang,Bo-yao Yu,Min Yu,Shiying Yuan,Bin Zang,Yuan-Fei Li,Fachun Zhou,Xiaomei Chen,Ming-Ju Wu,Yimin Li,Qian Guo,Yunlin Song,Kejian Qian,Xue-yan Liu,Zhiping Li,Cheng-Tao Sun,Zhongzhi Tang,Biao Ma,Zhi-Jie He,Lu Ke,Zhihui Tong,Weiqin Li,Yan Wang,Juan Xing,Zhong Wu Zhang,Fengjuan Guo,Lixin Zhou,Qindong Shi,Jun Lu,Ai-Bin Cheng,Peiyang Gao,Wei Xing,Anghui Zhang,Zhigang Zhou,Ting-Ting Zhou,Yang Liu,Fei Tong,Qiuhui Wang,Xiaobo Huang,Dongwu Shi,Wei Wang,Wei Li,Yingguang Xie,Rong-Ju Sun,Xi Gui Zheng,Jianbo Liu,Yu-chi Ai,Yanling Qu,Hailing Li,Zhiguo Pan,Dong Xu,Zhi-ye Zou,Yan Gao,Qiuye Kou,Xijing Zhang,Chuanyun Qian,Minjie Zhang,Yongjian Feng,Fusen Zhang,Yun Sun,Ping Chang,Bo Yu,Min Yu,Yijun Deng,Liyun Zhao,Yuanfei Li,M. Shao,Wei Wu,Ming Wu,Zhao Wu Zhang,Yimin Li,Qiang Guo,Zhiyong Wang,Yuanqi Gong,Yunlin Song,Baocai Fu,Chuanyong Gong,Jian Yu,Zhong Tang,Linxi Huang,Biao Ma,Zhijie He,Qingshan Zhou,Rongguo Yu +124 more
TL;DR: In this article , the authors developed an evidence-based feeding guideline for nutrition therapy in critical illness and conducted a large-scale, sufficiently powered study to ascertain the effects of guideline implementation on patient-centered outcomes.
Journal ArticleDOI
Relationship between microaspiration of gastric contents and ventilator-associated pneumonia.
TL;DR: Aspiration of gastric contents is common in critically ill patients, and has been identified as a risk factor for ventilator-associated pneumonia (VAP), but in many patients this event is not followed by any negative impact on patient outcome.
References
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Journal ArticleDOI
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.
Jean Louis Vincent,R. Moreno,Jukka Takala,Sheila Willatts,A. de Mendonça,Hajo A. Bruining,C. K. Reinhart,P. M. Suter,L. G. Thijs +8 more
TL;DR: The ESICM developed a so-called sepsis-related organ failure assessment (SOFA) score to describe quantitatively and as objectively as possible the degree of organ dysfunction/failure over time in groups of patients or even in individual patients.
Journal ArticleDOI
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
Richard Peto,M.C. Pike,P. Armitage,N. E. Breslow,David Cox,S V Howard,N Mantel,Klim McPherson,Julian Peto,Pete Smith +9 more
TL;DR: Efficient methods of analysis of randomized clinical trials in which the authors wish to compare the duration of survival among different groups of patients are described.
Journal ArticleDOI
A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study
TL;DR: The SAPS II, based on a large international sample of patients, provides an estimate of the risk of death without having to specify a primary diagnosis, and is a starting point for future evaluation of the efficiency of intensive care units.
Journal ArticleDOI
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
Andrew Rhodes,Laura Evans,Waleed Alhazzani,Mitchell M. Levy,Massimo Antonelli,Ricard Ferrer,Anand Kumar,Jonathan E. Sevransky,Charles L. Sprung,Mark E. Nunnally,Bram Rochwerg,Gordon D. Rubenfeld,Derek C. Angus,Djillali Annane,Richard Beale,Geoffrey J. Bellinghan,Gordon R. Bernard,Jean Daniel Chiche,Craig M. Coopersmith,Daniel De Backer,Craig French,Seitaro Fujishima,Herwig Gerlach,Jorge Hidalgo,Steven M. Hollenberg,Alan E. Jones,Dilip R. Karnad,Ruth M. Kleinpell,Younsuck Koh,Thiago Lisboa,Flávia Ribeiro Machado,John J. Marini,John C. Marshall,John E. Mazuski,Lauralyn McIntyre,Anthony S. McLean,Sangeeta Mehta,Rui Moreno,John Myburgh,Paolo Navalesi,Osamu Nishida,Tiffany M. Osborn,Anders Perner,Colleen M. Plunkett,Marco Ranieri,Christa A. Schorr,Maureen A. Seckel,Christopher W. Seymour,Lisa Shieh,Khalid A. Shukri,Steven Q. Simpson,Mervyn Singer,B. Taylor Thompson,Sean R. Townsend,Thomas Van der Poll,Jean Louis Vincent,W. Joost Wiersinga,Janice L. Zimmerman,R. Phillip Dellinger +58 more
TL;DR: Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
Journal ArticleDOI
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design.
Richard Peto,M.C. Pike,P. Armitage,N. E. Breslow,David Cox,S V Howard,N Mantel,Klim McPherson,Julian Peto,Pete Smith +9 more
TL;DR: This report is the first simple account yet published for non-statistical physicians of how to analyse efficiently data from clinical trials of survival duration, and it may be preferable to use these statistical methods to study time to local recurrence of tumour, or toStudy time to detectable metastatic spread, in addition to studying total survival.
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