Journal ArticleDOI
Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2)
Jean Reignier,Julie Boisramé-Helms,L. Brisard,Jean-Baptiste Lascarrou,Ali Ait Hssain,Nadia Anguel,Laurent Argaud,Karim Asehnoune,Pierre Asfar,Frédéric Bellec,Vlad Botoc,Anne Bretagnol,Hoang-Nam Bui,Emmanuel Canet,Daniel da Silva,Michael Darmon,Vincent Das,Jérôme Devaquet,Michel Djibré,Frédérique Ganster,Maité Garrouste-Orgeas,Stéphane Gaudry,Olivier Gontier,Claude Guérin,Bertrand Guidet,Christophe Guitton,Jean-Etienne Herbrecht,Jean-Claude Lacherade,Philippe Letocart,Frédéric Martino,Virginie Maxime,Emmanuelle Mercier,Jean-Paul Mira,Saad Nseir,Gaël Piton,Jean-Pierre Quenot,Jack Richecoeur,Jean-Philippe Rigaud,René Robert,Nathalie Rolin,Carole Schwebel,Michel Sirodot,François Tinturier,Didier Thevenin,Bruno Giraudeau,Amélie Le Gouge,Amélie Le Gouge,Hervé Dupont,Marc Pierrot,François Beloncle,Danièle Combaux,Romain Mercier,Hadrien Winiszewski,Gilles Capellier,Gilles Hilbert,Didier Gruson,Pierre Kalfon,Bertrand Souweine,Elizabeth Coupez,Jean-Damien Ricard,Jonathan Messika,François Bougerol,Pierre-Louis Declercq,Auguste Dargent,Audrey Large,Djillali Annane,Bernard Clair,Agnès Bonadona,Rebecca Hamidfar,Christian Richard,Mathieu Henry-Lagarrigue,Ahiem Yehia Yehia,Johanna Temime,Stephanie Barrailler,Raphael Favory,Erika Parmentier-Decrucq,Mercé Jourdain,Loredana Baboi,Marie Simon,Thomas Baudry,Mehran Monchi,Jérôme Roustan,Patrick Bardou,Alice Cottereau,Philippe Guiot,Noelle Brule,Mickael Landais,Antoine Roquilly,Thierry Boulain,Dalila Benzekri,Benoit Champigneulle,Jalel Tahiri,Gabriel Preda,Benoit Misset,Virginie Lemiale,Lara Zafrani,Muriel Fartoukh,Guillaume Thiery,Delphine Chatellier,Rémi Coudroy,Renaud Chouquer,Christine Brasse,Arnaud Delahaye,Luís Carlos de Souza Ferreira,Régine Vermesch,Stéphanie Chevalier,Charlotte Quentin,Quentin Maestraggi,Francis Schneider,Ferhat Meziani,Charles Cerf,Grégoire Trebbia,Charlotte Salmon-Gandonnière,Laetitia Bodet-Contentin +113 more
TLDR
In critically ill adults with shock, early isocaloric enteral nutrition did not reduce mortality or the risk of secondary infections but was associated with a greater risk of digestive complications compared with early isocallyoric parenteral nutrition.About:
This article is published in The Lancet.The article was published on 2018-01-13. It has received 346 citations till now. The article focuses on the topics: Parenteral nutrition & Enteral administration.read more
Citations
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Journal ArticleDOI
Changing paradigms in metabolic support and nutrition therapy during critical illness.
TL;DR: The most recent advances in acute metabolic care and critical care nutrition are summarized to summarize the most recent findings.
Journal ArticleDOI
Intensive Care Nutrition and Post-Intensive Care Recovery.
Jan Gunst,Greet Van den Berghe +1 more
TL;DR: The ideal timing of artificial nutrition for critically ill patients as well as the optimal dose and composition remain unclear and may be explained by feeding-induced suppression of autophagy.
Journal ArticleDOI
Route, early or energy? … Protein improves protein balance in critically ill patients
TL;DR: The focus of this research has been caloric delivery and it has been shown that muscle (protein) mass at admission to the ICU is relevant for the outcome of ICU patients and this positive effect on protein balance is lasting.
Journal ArticleDOI
Prognostic Value of Both Plasma Volume Status and Nutritional Status in Patients With Severely Decompensated Acute Heart Failure.
Akihiro Shirakabe,Kuniya Asai,Nobuaki Kobayashi,Hirotake Okazaki,Masato Matsushita,Yusaku Shibata,Hiroki Goda,Shota Shigihara,Kazuhiro Asano,Kenichi Tani,Kazutaka Kiuchi,Noritake Hata,Wataru Shimizu +12 more
TL;DR: The simultaneous evaluation of nutrition status and PVS is essential to predict an AHF outcome; furthermore, a malnutrition status with a high PVS leads to an adverse outcome.
Journal ArticleDOI
Propensity-Score Matched Comparative Study on Effects of Intravenous Human Serum Albumin Administration in Critically Ill Adult Patients Receiving Parenteral Nutrition.
TL;DR: Patients receiving IV HSA and PN for several days increased serum albumin level, but decreased non-serum-albumin plasma protein levels, suggesting bilirubin clearance could be slightly impaired in these patients.
References
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Journal ArticleDOI
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.
Jean Louis Vincent,R. Moreno,Jukka Takala,Sheila Willatts,A. de Mendonça,Hajo A. Bruining,C. K. Reinhart,P. M. Suter,L. G. Thijs +8 more
TL;DR: The ESICM developed a so-called sepsis-related organ failure assessment (SOFA) score to describe quantitatively and as objectively as possible the degree of organ dysfunction/failure over time in groups of patients or even in individual patients.
Journal ArticleDOI
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
Richard Peto,M.C. Pike,P. Armitage,N. E. Breslow,David Cox,S V Howard,N Mantel,Klim McPherson,Julian Peto,Pete Smith +9 more
TL;DR: Efficient methods of analysis of randomized clinical trials in which the authors wish to compare the duration of survival among different groups of patients are described.
Journal ArticleDOI
A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study
TL;DR: The SAPS II, based on a large international sample of patients, provides an estimate of the risk of death without having to specify a primary diagnosis, and is a starting point for future evaluation of the efficiency of intensive care units.
Journal ArticleDOI
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
Andrew Rhodes,Laura Evans,Waleed Alhazzani,Mitchell M. Levy,Massimo Antonelli,Ricard Ferrer,Anand Kumar,Jonathan E. Sevransky,Charles L. Sprung,Mark E. Nunnally,Bram Rochwerg,Gordon D. Rubenfeld,Derek C. Angus,Djillali Annane,Richard Beale,Geoffrey J. Bellinghan,Gordon R. Bernard,Jean Daniel Chiche,Craig M. Coopersmith,Daniel De Backer,Craig French,Seitaro Fujishima,Herwig Gerlach,Jorge Hidalgo,Steven M. Hollenberg,Alan E. Jones,Dilip R. Karnad,Ruth M. Kleinpell,Younsuck Koh,Thiago Lisboa,Flávia Ribeiro Machado,John J. Marini,John C. Marshall,John E. Mazuski,Lauralyn McIntyre,Anthony S. McLean,Sangeeta Mehta,Rui Moreno,John Myburgh,Paolo Navalesi,Osamu Nishida,Tiffany M. Osborn,Anders Perner,Colleen M. Plunkett,Marco Ranieri,Christa A. Schorr,Maureen A. Seckel,Christopher W. Seymour,Lisa Shieh,Khalid A. Shukri,Steven Q. Simpson,Mervyn Singer,B. Taylor Thompson,Sean R. Townsend,Thomas Van der Poll,Jean Louis Vincent,W. Joost Wiersinga,Janice L. Zimmerman,R. Phillip Dellinger +58 more
TL;DR: Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
Journal ArticleDOI
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design.
Richard Peto,M.C. Pike,P. Armitage,N. E. Breslow,David Cox,S V Howard,N Mantel,Klim McPherson,Julian Peto,Pete Smith +9 more
TL;DR: This report is the first simple account yet published for non-statistical physicians of how to analyse efficiently data from clinical trials of survival duration, and it may be preferable to use these statistical methods to study time to local recurrence of tumour, or toStudy time to detectable metastatic spread, in addition to studying total survival.
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