Eosinophils from Physiology to Disease: A Comprehensive Review.
Giuseppe A. Ramirez,Mona-Rita Yacoub,Marco Ripa,Daniele Mannina,Adriana Cariddi,Nicoletta Saporiti,Fabio Ciceri,Antonella Castagna,Giselda Colombo,Lorenzo Dagna +9 more
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TLDR
A comprehensive update on the pathophysiological role of eosinophils in host defence, inflammation, and cancer is provided and potential clinical implications are discussed in light of recent therapeutic advances.Abstract:
Despite being the second least represented granulocyte subpopulation in the circulating blood, eosinophils are receiving a growing interest from the scientific community, due to their complex pathophysiological role in a broad range of local and systemic inflammatory diseases as well as in cancer and thrombosis. Eosinophils are crucial for the control of parasitic infections, but increasing evidence suggests that they are also involved in vital defensive tasks against bacterial and viral pathogens including HIV. On the other side of the coin, eosinophil potential to provide a strong defensive response against invading microbes through the release of a large array of compounds can prove toxic to the host tissues and dysregulate haemostasis. Increasing knowledge of eosinophil biological behaviour is leading to major changes in established paradigms for the classification and diagnosis of several allergic and autoimmune diseases and has paved the way to a “golden age” of eosinophil-targeted agents. In this review, we provide a comprehensive update on the pathophysiological role of eosinophils in host defence, inflammation, and cancer and discuss potential clinical implications in light of recent therapeutic advances.read more
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The Dynamics of the Skin's Immune System
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Cells of the Immune System in Cardiac Remodeling: Main Players in Resolution of Inflammation and Repair After Myocardial Infarction.
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Subcutaneous mepolizumab in children aged 6 to 11 years with severe eosinophilic asthma.
Atul Gupta,Isabelle Pouliquen,Daren Austin,Robert G. Price,Rodger Kempsford,Jonathan Steinfeld,Eric S. Bradford,Steven W. Yancey +7 more
TL;DR: The pharmacokinetics and pharmacodynamics of mepolizumab following subcutaneous (SC) administration in children 6 to 11 years of‐age with severe eosinophilic asthma are characterized.
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Immune cells as tumor drug delivery vehicles.
TL;DR: Increasing the circulatory half-life and development of conditional release strategies as the two main future pillars to improve the efficacy of immune cell-mediated drug delivery to tumors are proposed.
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The role of eosinophils in chronic spontaneous urticaria
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TL;DR: A new picture of an important role of eosinophils in the pathogenesis of CSU is emerging, and treatments aimed at reducing eOSinophil accumulation and activation, such as the anti-IL-5 antibodies mepolizumab, resl Lizumab and benralizumAB, have been reported to reduce CSU symptoms.
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