Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TLDR
Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.About:
This article is published in The Lancet.The article was published on 2020-01-30 and is currently open access. It has received 16282 citations till now.read more
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Suppressed T cell-mediated immunity in patients with COVID-19: A clinical retrospective study in Wuhan, China.
Bo Xu,Cun-yu Fan,An-lu Wang,Yi-long Zou,Yi-han Yu,Cong He,Wen-guang Xia,Ji-xian Zhang,Qing Miao +8 more
TL;DR: A significant decrease of T lymphocyte subset is positively correlated with in-hospital death and severity of illness, which may shed light on early warning of high risks of mortality and help early intervention and treatment of COVID-19.
Journal ArticleDOI
SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression.
TL;DR: A hypothesis based on strong scientific documentation, associating oxidative stress with changes found in patients with COVID-19, such as its participation in the amplification and perpetuation of the cytokine storm, coagulopathy, and cell hypoxia is proposed.
Journal ArticleDOI
COVID-19 and the potential long-term impact on antimicrobial resistance.
Timothy M. Rawson,Timothy M. Rawson,Timothy M. Rawson,Luke S. P. Moore,Luke S. P. Moore,Enrique Castro-Sánchez,Esmita Charani,Esmita Charani,Frances Davies,Frances Davies,Giovanni Satta,Giovanni Satta,Matthew J. Ellington,Alison Holmes,Alison Holmes,Alison Holmes +15 more
TL;DR: The emergence of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has required an unprecedented response to control the spread of the infection and protect the most vulnerable within society.
Journal ArticleDOI
Serum Cytokine and Chemokine Profile in Relation to the Severity of Coronavirus Disease 2019 in China.
Ying Chi,Yiyue Ge,Bin Wu,Wenshuai Zhang,Tao Wu,Tian Wen,Jingxian Liu,Xiling Guo,Chao Huang,Yongjun Jiao,Fengcai Zhu,Baoli Zhu,Baoli Zhu,Lunbiao Cui +13 more
TL;DR: It is suggested that combinatorial analysis of serum cytokines and chemokines with clinical classification may contribute to evaluation of the severity of COVID-19 and optimize the therapeutic strategies.
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The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro
Xi Wang,Ruiyuan Cao,Huanyu Zhang,J.D. Liu,Mingyue Xu,Hengrui Hu,Yufeng Li,Lei Zhao,Wei Li,Xiulian Sun,Xing-Lou Yang,Zhengli Shi,Fei Deng,Zhihong Hu,Wu Zhong,Manli Wang +15 more
TL;DR: Six currently available and licensed anti-influenza drugs against SARS-CoV-2 are evaluated and it is suggested that arbidol treatment showed tendency to improve the discharging rate and decrease the mortality rate of COVID-19 patients.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
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TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
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Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
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The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China.
David S.C. Hui,Esam Ei Azhar,Tariq A. Madani,Francine Ntoumi,Richard Kock,Osman Dar,Giuseppe Ippolito,Timothy D. McHugh,Ziad A. Memish,Christian Drosten,Alimuddin Zumla,Eskild Petersen +11 more
TL;DR: The recent outbreak of clusters of viral pneumonia due to a 2019-nCoV in the Wuhan market poses significant threats to international health and may be related to sale of bush meat derived from wild or captive sources at the seafood market.
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