Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TLDR
Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.About:
This article is published in The Lancet.The article was published on 2020-01-30 and is currently open access. It has received 16282 citations till now.read more
Citations
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Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs.
Zhe Li,Xin Li,Yi-You Huang,Yaoxing Wu,Runduo Liu,Lingli Zhou,Yuxi Lin,Yuxi Lin,Deyan Wu,Lei Zhang,Hao Liu,Ximing Xu,Kunqian Yu,Yuxia Zhang,Jun Cui,Chang-Guo Zhan,Xin Wang,Hai-Bin Luo +17 more
TL;DR: It has been demonstrated that a new virtual screening approach with accelerated free energy perturbation-based absolute binding free energy (FEP-ABFE) predictions can reach an unprecedentedly high hit rate, leading to successful identification of 15 potent inhibitors of SARS-CoV-2 main protease (Mpro) from 25 computationally selected drugs under a threshold of Ki = 4 μM.
Journal ArticleDOI
Reproductive number of coronavirus: A systematic review and meta-analysis based on global level evidence.
TL;DR: The estimated summary reproductive number indicates an exponential increase of coronavirus infection in the coming days, based on available global level evidence.
Journal ArticleDOI
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
TL;DR: The physiological body distribution, expression, and activities of ACE2 are mapped and its potential correlations and mutal interactions with the disparate symptoms present in SARS-CoV-2 patients at the level of different organs are discussed.
Journal ArticleDOI
Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease.
Joseph W. Golden,Curtis R. Cline,Xiankun Zeng,Aura R. Garrison,Brian D. Carey,Eric M. Mucker,Lauren E. White,Joshua D. Shamblin,Rebecca L. Brocato,Jun Liu,April M. Babka,Hypaitia B. Rauch,Jeffrey M. Smith,Bradley S. Hollidge,Collin Fitzpatrick,Catherine V. Badger,Jay W. Hooper +16 more
TL;DR: To the authors' knowledge, this is the first highly lethal murine infection model for SARS-CoV-2 and should be valuable for the study of Sars-Cov-2 pathogenesis and for the assessment of MCMs.
Journal ArticleDOI
Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms.
TL;DR: The physiological properties of the BBB that makes the CNS an immune‐privileged organ are summarized and the relevance of peripheral inflammation‐induced BBB disruption to various CNS diseases are discussed.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
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TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
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Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
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The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China.
David S.C. Hui,Esam Ei Azhar,Tariq A. Madani,Francine Ntoumi,Richard Kock,Osman Dar,Giuseppe Ippolito,Timothy D. McHugh,Ziad A. Memish,Christian Drosten,Alimuddin Zumla,Eskild Petersen +11 more
TL;DR: The recent outbreak of clusters of viral pneumonia due to a 2019-nCoV in the Wuhan market poses significant threats to international health and may be related to sale of bush meat derived from wild or captive sources at the seafood market.
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