Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TLDR
Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.About:
This article is published in The Lancet.The article was published on 2020-01-30 and is currently open access. It has received 16282 citations till now.read more
Citations
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Prevalence and severity of corona virus disease 2019 (COVID-19): A systematic review and meta-analysis.
TL;DR: A meta-analysis of clinical and epidemiological studies on confirmed cases of COVID-19 found the case severe rate and mortality is lower than that of SARS and MERS, and the most prevalent comorbidities are hypertension and diabetes which are associated with the severity of CO VID-19.
Journal ArticleDOI
Co-infection with respiratory pathogens among COVID-2019 cases.
Xiaojuan Zhu,Yiyue Ge,Tao Wu,Kangchen Zhao,Yin Chen,Bin Wu,Fengcai Zhu,Baoli Zhu,Baoli Zhu,Lunbiao Cui +9 more
TL;DR: Bacterial co-infections were dominant in all COVID-19 patients, Streptococcus pneumoniae was the most common, followed by Klebsiella pneumoniae and Haemophilus influenzae, and the highest and lowest rates of co- Infections were found in patients aged 15–44 and below 15, respectively.
Journal ArticleDOI
A systematic review of SARS-CoV-2 vaccine candidates.
TL;DR: An overview of the experimental and clinical data obtained from recent SARS-CoV-2 vaccines trials are provided, and certain potential safety issues that require consideration when developing vaccines are highlighted.
Journal ArticleDOI
The establishment of reference sequence for SARS‐CoV‐2 and variation analysis
TL;DR: There may be selective mutations in SARS‐COV‐2, and it is necessary to avoid certain regions when designing primers and probes, and establishment of the reference sequence could benefit not only biological study of this virus but also diagnosis, clinical monitoring and intervention of Sars‐CoV‐ 2 infection in the future.
Journal ArticleDOI
Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection.
Christoph B. Messner,Vadim Demichev,Vadim Demichev,Daniel Wendisch,Laura Michalick,Matthew White,Anja Freiwald,Kathrin Textoris-Taube,Spyros I. Vernardis,Anna Sophia Egger,Marco Kreidl,Daniela Ludwig,Christiane Kilian,Federica Agostini,Aleksej Zelezniak,Aleksej Zelezniak,Charlotte Thibeault,Moritz Pfeiffer,Stefan Hippenstiel,Andreas C. Hocke,Christof von Kalle,Archie Campbell,Caroline Hayward,David J. Porteous,Riccardo E. Marioni,Claudia Langenberg,Claudia Langenberg,Kathryn S. Lilley,Wolfgang M. Kuebler,Michael Mülleder,Christian Drosten,Norbert Suttorp,Martin Witzenrath,Florian Kurth,Florian Kurth,Leif E. Sander,Markus Ralser,Markus Ralser +37 more
TL;DR: A platform for ultra-high throughput serum and plasma proteomics that builds on ISO13485 standardisation and high-flow liquid chromatography to facilitate implementation in clinical laboratories and identifies 27 potential biomarkers that are differentially expressed depending on the WHO severity grade of COVID-19.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
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Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
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The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China.
David S.C. Hui,Esam Ei Azhar,Tariq A. Madani,Francine Ntoumi,Richard Kock,Osman Dar,Giuseppe Ippolito,Timothy D. McHugh,Ziad A. Memish,Christian Drosten,Alimuddin Zumla,Eskild Petersen +11 more
TL;DR: The recent outbreak of clusters of viral pneumonia due to a 2019-nCoV in the Wuhan market poses significant threats to international health and may be related to sale of bush meat derived from wild or captive sources at the seafood market.
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