Journal ArticleDOI
Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn’s disease: results from a multicenter phase I/IIa clinical trial
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TLDR
Locally injected eASCs appear to be a simple, safe, and beneficial therapy for perianal fistula in Crohn’s disease patients, and additional studies are needed to further confirm the efficacy of the eASC.Abstract:
Purpose
The management of perianal fistula in patients with Crohn’s disease is an extremely challenging medical problem as many fistulas do not respond to available treatments The objectives were to assess the safety and efficacy of a suspension of expanded adipose-derived allogeneic mesenchymal stem cells (eASCs) for the treatment of complex perianal fistula in Crohn’s diseaseread more
Citations
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Journal ArticleDOI
British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults
Christopher A. Lamb,Christopher A. Lamb,Nicholas A. Kennedy,Tim Raine,P Hendy,P Hendy,Philip J Smith,Jimmy K. Limdi,Jimmy K. Limdi,Bu'Hussain Hayee,Bu'Hussain Hayee,Miranda Lomer,Miranda Lomer,Gareth Parkes,Gareth Parkes,Christian P. Selinger,Christian P. Selinger,Kevin Barrett,R Justin Davies,Cathy Bennett,Stuart Gittens,Malcolm G. Dunlop,Malcolm G. Dunlop,Omar Faiz,Aileen Fraser,Vikki Garrick,Paul D Johnston,Miles Parkes,Jeremy D. Sanderson,Jeremy D. Sanderson,Helen Terry,Daniel R. Gaya,Daniel R. Gaya,Tariq Iqbal,Tariq Iqbal,Stuart A. Taylor,Stuart A. Taylor,Melissa A. Smith,Melissa A. Smith,Matthew J Brookes,Richard Hansen,A Barney Hawthorne +41 more
TL;DR: Comprehensive up-to-date guidance is provided regarding indications for, initiation and monitoring of immunosuppressive therapies, nutrition interventions, pre-, peri- and postoperative management, as well as structure and function of the multidisciplinary team and integration between primary and secondary care.
Journal ArticleDOI
Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial.
Julián Panés,Damián García-Olmo,Gert Van Assche,Jean-Frederic Colombel,Walter Reinisch,Walter Reinisch,Daniel C. Baumgart,Axel Dignass,Maria Nachury,Marc Ferrante,Lili Kazemi-Shirazi,Jean Charles Grimaud,Fernando de la Portilla,Eran Goldin,Marie Paule Richard,Anne Leselbaum,Silvio Danese +16 more
TL;DR: Cx601 is an effective and safe treatment for complex perianal fistulas in patients with Crohn's disease who did not respond to conventional or biological treatments, or both.
Journal ArticleDOI
ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment
Joana Torres,Stefanos Bonovas,Glen A. Doherty,Torsten Kucharzik,Javier P. Gisbert,Tim Raine,Michel Adamina,Michel Adamina,Alessandro Armuzzi,Oliver Bachmann,Palle Bager,Livia Biancone,Bernd Bokemeyer,Peter Bossuyt,Johan Burisch,Paul Collins,Alaa El-Hussuna,Pierre Ellul,Cornelia Frei-Lanter,Federica Furfaro,Christian Gingert,Paolo Gionchetti,Fernando Gomollón,Marien González-Lorenzo,Hannah Gordon,Tibor Hlavaty,Pascal Juillerat,Konstantinos H. Katsanos,Uri Kopylov,Eduards Krustins,Theodore Lytras,Christian Maaser,Fernando Magro,John Marshall,Pär Myrelid,Gianluca Pellino,Isadora Rosa,João Sabino,Edoardo Savarino,Antonino Spinelli,Laurents P. S. Stassen,Mathieu Uzzan,Stephan R. Vavricka,Bram Verstockt,Janindra Warusavitarne,Oded Zmora,Gionata Fiorino +46 more
TL;DR: The present article addresses surgical management, including preoperative aspects and drug management before surgery, and provides technical advice for a variety of common clinical situations.
Journal ArticleDOI
Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study
Guoping Zheng,Lanfang Huang,Haijiang Tong,Qiang Shu,Yaoqin Hu,Menghua Ge,Keqin Deng,Liuya Zhang,Bin Zou,Baoli Cheng,Jianguo Xu +10 more
TL;DR: Administration of allogeneic adipose-derived MSCs appears to be safe and feasible in the treatment of ARDS, and further optimization of this strategy will probably be required to reach the goal of reduced alveolar epithelial injury in ARDS.
Journal ArticleDOI
A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease
Krisztina B Gecse,Krisztina B Gecse,Willem A. Bemelman,Michael A. Kamm,Jaap Stoker,Reena Khanna,Reena Khanna,Siew C. Ng,Julián Panés,Gert Van Assche,Zhanju Liu,Ailsa Hart,Barrett G. Levesque,Barrett G. Levesque,Geert R. D'Haens,Geert R. D'Haens +15 more
TL;DR: A consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease (pCD), based on best available evidence is developed.
References
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Journal ArticleDOI
Allogeneic Mesenchymal Stem Cells: Agents of Immune Modulation
Karen English,Bernard P. Mahon +1 more
TL;DR: This review describes recent advances in understanding the mechanistic basis of mesenchymal stromal or stem cells (MSC) interaction with innate immunity and particular emphasis is placed on the effect of Toll‐like receptor signalling on MSC.
Journal Article
Immunoregulatory Function of Mesenchymal Stem Cells
TL;DR: Mesenchymal stem cells (MSC) interact with hematopoietic stem cells and support their growth and differentiation in the bone marrow as mentioned in this paper, which is a promising tool for tissue repairs.
Journal ArticleDOI
Adult stem cells in the treatment of autoimmune diseases
J.M. van Laar,A. Tyndall +1 more
TL;DR: Results from in vitro experiments, animal models and early human experience in severe acute graft vs host disease suggest that multipotent mesenchymal stromal cells obtained from the bone marrow and expanded ex vivo, may exert a clinically useful immunomodulatory effect.
Journal ArticleDOI
Human Adipose-Derived Stem Cells Impair Natural Killer Cell Function and Exhibit Low Susceptibility to Natural Killer-Mediated Lysis
Olga DelaRosa,Beatriz Sanchez-Correa,Sara Morgado,Cristina Ramírez,Borja del Río,Ramón Menta,Eleuterio Lombardo,Raquel Tarazona,Javier G. Casado +8 more
TL;DR: It is demonstrated that hASCs and hBM-MSCs can modulate NK cells through the action of soluble factors such as indoleamine 2,3-dioxygenase, and suggest that for an adoptive cell therapy based on the transfer of allogeneic h ASCs, the NK-hASCs crosstalk will not result in an immediate recognition of the transferred cells.
Journal ArticleDOI
Human mesenchymal stem cell transformation is associated with a mesenchymal-epithelial transition.
Daniel Rubio,Silvia Garcia,Teresa de la Cueva,Ma F. Paz,Alison C. Lloyd,Antonio Bernad,Javier García-Castro +6 more
TL;DR: The hypothesis that some carcinomas are derived from mesenchymal rather than from epithelial precursors is supported, suggesting a dedifferentiation process was associated with the mesenchyal stem cell (MSC) transformation.