Exploring the virome of diseased horses.
Linlin Li,Federico Giannitti,Jason Low,Casey Keyes,Leila Sabrina Ullmann,Xutao Deng,Xutao Deng,Monica R Aleman,Patricia A. Pesavento,Nicola Pusterla,Eric Delwart,Eric Delwart +11 more
TLDR
The number of viruses found in horses is expanded, and their genomes are characterized to assist future epidemiological studies of their transmission and potential association with various equine diseases.Abstract:
Metagenomics was used to characterize viral genomes in clinical specimens of horses with various organ-specific diseases of unknown aetiology. A novel parvovirus as well as a previously described hepacivirus closely related to human hepatitis C virus and equid herpesvirus 2 were identified in the cerebrospinal fluid of horses with neurological signs. Four co-infecting picobirnaviruses, including an unusual genome with fused RNA segments, and a divergent anellovirus were found in the plasma of two febrile horses. A novel cyclovirus genome was characterized from the nasal secretion of another febrile animal. Lastly, a small circular DNA genome with a Rep gene, from a virus we called kirkovirus, was identified in the liver and spleen of a horse with fatal idiopathic hepatopathy. This study expands the number of viruses found in horses, and characterizes their genomes to assist future epidemiological studies of their transmission and potential association with various equine diseases.read more
Citations
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Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins ( Manis javanica )
Ping Liu,Wu Chen,Jin-Ping Chen +2 more
TL;DR: This is the first report on the viral diversity of pangolins, expanding the understanding of the virome in endangered species, and providing insight into the overall diversity of viruses that may be capable of directly or indirectly crossing over into other mammals.
Journal ArticleDOI
Revisiting the Taxonomy of the Family Circoviridae: Establishment of the Genus Cyclovirus and Removal of the Genus Gyrovirus
Karyna Rosario,Mya Breitbart,Balázs Harrach,Joaquim Segalés,Eric Delwart,Eric Delwart,Philippe Biagini,Arvind Varsani,Arvind Varsani +8 more
TL;DR: Details are provided on an updated Circoviridae taxonomy ratified by the International Committee on the Taxonomy of Viruses in 2016, which establishes the genus Cyclovirus and reassigns the genus Gyrovirus to the family Anelloviraceae, a separate lineage of animal viruses that also contains circular ssDNA genomes.
Journal ArticleDOI
Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children.
Guoyan Zhao,Tommi Vatanen,Tommi Vatanen,Lindsay Droit,Arnold Park,Aleksandar Kostic,Tiffany W. Poon,Hera Vlamakis,Heli Siljander,Heli Siljander,Taina Härkönen,Taina Härkönen,Anu Maaria Hämäläinen,Aleksandr Peet,Aleksandr Peet,Vallo Tillmann,Vallo Tillmann,Jorma Ilonen,David Wang,Mikael Knip,Ramnik J. Xavier,Ramnik J. Xavier,Herbert W. Virgin +22 more
TL;DR: It was found that the intestinal viromes of cases were less diverse than those of controls and eukaryotic viruses and bacteriophage contigs that are associated with the presence or absence of autoimmunity and disease-associated viral bacteriophile contigs were statistically linked to specific components of the bacterial microbiome.
Book ChapterDOI
Eukaryotic Circular Rep-Encoding Single-Stranded DNA (CRESS DNA) Viruses: Ubiquitous Viruses With Small Genomes and a Diverse Host Range
TL;DR: The explosion of sequence diversity and expansion of eukaryotic CRESS DNA taxonomic groups over the last decade is surveyed, similarities between the well-studied geminiviruses and circoviruses with newly identified groups known only through their genome sequences are highlighted, and the ecology and evolution of eUKaryoticCRESS DNA viruses are discussed.
Journal ArticleDOI
Virome comparisons in wild-diseased and healthy captive giant pandas.
Wen Zhang,Wen Zhang,Shixing Yang,Tongling Shan,Rong Hou,Zhijian Liu,Wang Li,Lianghua Guo,Yan Wang,Peng Chen,Xiaochun Wang,Feifei Feng,Hua Wang,Chen Chao,Quan Shen,Chenglin Zhou,Xiuguo Hua,Li Cui,Xutao Deng,Zhihe Zhang,Dunwu Qi,Eric Delwart +21 more
TL;DR: The similar viral families detected in sick and healthy giant pandas indicate that these viruses result in commensal infections in most immuno-competent animals.
References
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A geminivirus-related DNA mycovirus that confers hypovirulence to a plant pathogenic fungus
Xiao Yu,Bo Li,Yanping Fu,Daohong Jiang,Said A. Ghabrial,Guoqing Li,You-Liang Peng,Jiatao Xie,Jiasen Cheng,Junbin Huang,Xianhong Yi +10 more
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