Extracellular vesicles tell all: How vesicle-mediated cellular communication shapes hematopoietic stem cell biology with increasing age
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In this article, a review summarizes the current literature dealing with how age-altered intercellular communication mediated by Extracellular Vesicles (EVs) influences HSC biology.About:
This article is published in Experimental Hematology.The article was published on 2021-09-01 and is currently open access. It has received 1 citations till now. The article focuses on the topics: Vesicle.read more
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Spinal cord injury reprograms muscle fibro-adipogenic progenitors to formheterotopic bones within muscles
Hsu-Wen Tseng,Dorothée Girard,Kylie A. Alexander,Susan M. Millard,Frédéric Torossian,Adrienne Anginot,Whitney Fleming,Jules Gueguen,M.-E. Goriot,Denis Clay,Beulah Jose,B. Nowlan,Allison R. Pettit,Marjorie Salga,François Genêt,M.-C. Bousse-Kerdiles,Sébastien Banzet,Jean-Pierre Levesque +17 more
TL;DR: The cells-of-origin of neurogenic heterotopic ossifications (NHO), which develop frequently in the periarticular muscles following spinal cord injuries (SCI) and traumatic brain injuries, remain unclear because the skeletal muscle harbors two progenitor cell populations: satellite cells (SCs) and fibro-adipogenic progenitors (FAPs) which are mesenchymal.
References
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Journal ArticleDOI
Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons
Mathilde Chivet,Charlotte Javalet,Karine Laulagnier,Béatrice Blot,Fiona J. Hemming,Rémy Sadoul +5 more
TL;DR: It is demonstrated for the first time that exosomes released upon synaptic activation do not bind to glial cells but selectively to other neurons suggesting that they can underlie a novel aspect of interneuronal communication.
Journal ArticleDOI
Ion flux and the function of endosomes and lysosomes: pH is just the start: the flux of ions across endosomal membranes influences endosome function not only through regulation of the luminal pH.
Cameron C. Scott,Jean Gruenberg +1 more
TL;DR: Intriguingly, many of the defects of the endo‐lysomal system attributed to aberrant pH persist in the Cl−‐deficient mice implying a direct regulatory role for Cl− influx in endosome function.
Journal ArticleDOI
RNA Trafficking by Acute Myelogenous Leukemia Exosomes
Jianya Huan,Noah I. Hornick,Matthew J Shurtleff,Amy M. Skinner,Natalya A. Goloviznina,Charles T. Roberts,Peter Kurre +6 more
TL;DR: It is revealed that AML exosome trafficking alters the proliferative, angiogenic, and migratory responses of cocultured stromal and hematopoietic progenitor cell lines, helping explain how the microenvironmental niche becomes reprogrammed during invasion of the bone marrow by AML.
Journal ArticleDOI
Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication
TL;DR: New, and therefore still relatively poorly known vesicles are apoptotic bodies, on which numerous in-depth studies are needed in order to understand their role and possible function.
Journal ArticleDOI
Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.
Gudmundur L. Norddahl,Cornelis J.H. Pronk,Martin Wahlestedt,Gerd Sten,Jens M. Nygren,Jens M. Nygren,Amol Ugale,Mikael Sigvardsson,David Bryder +8 more
TL;DR: Results show that intact mitochondrial function is required for appropriate multilineage stem cell differentiation, but argue against mitochondrial DNA mutations per se being a primary driver of somatic stem cell aging.
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