Extracellular vesicles tell all: How vesicle-mediated cellular communication shapes hematopoietic stem cell biology with increasing age
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TLDR
In this article, a review summarizes the current literature dealing with how age-altered intercellular communication mediated by Extracellular Vesicles (EVs) influences HSC biology.About:
This article is published in Experimental Hematology.The article was published on 2021-09-01 and is currently open access. It has received 1 citations till now. The article focuses on the topics: Vesicle.read more
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Spinal cord injury reprograms muscle fibro-adipogenic progenitors to formheterotopic bones within muscles
Hsu-Wen Tseng,Dorothée Girard,Kylie A. Alexander,Susan M. Millard,Frédéric Torossian,Adrienne Anginot,Whitney Fleming,Jules Gueguen,M.-E. Goriot,Denis Clay,Beulah Jose,B. Nowlan,Allison R. Pettit,Marjorie Salga,François Genêt,M.-C. Bousse-Kerdiles,Sébastien Banzet,Jean-Pierre Levesque +17 more
TL;DR: The cells-of-origin of neurogenic heterotopic ossifications (NHO), which develop frequently in the periarticular muscles following spinal cord injuries (SCI) and traumatic brain injuries, remain unclear because the skeletal muscle harbors two progenitor cell populations: satellite cells (SCs) and fibro-adipogenic progenitors (FAPs) which are mesenchymal.
References
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Journal ArticleDOI
Platelet-derived microvesicles transfer tissue factor to monocytes but not to neutrophils
TL;DR: The data indicate that the transfer of TF to monocyte is not simply an CD62P-mediated adhesion of platelets or PMV to monocytes, but may involve other not yet identified mechanisms.
Journal ArticleDOI
The bone-marrow niche in MDS and MGUS: implications for AML and MM
TL;DR: The concept that the haematopoietic neoplasia–microenvironment relationship is an intimate rapport between two partners is focused on, an overview of the evidence supporting a role for the bone-marrow niche in promotingNeoplasia is provided, and the potential for niche-specific therapeutic targets is discussed.
Journal ArticleDOI
Chaperone-mediated autophagy sustains haematopoietic stem-cell function
Shuxian Dong,Qian Wang,Yun Ruei Kao,Antonio Diaz,Inmaculada Tasset,Susmita Kaushik,Victor Thiruthuvanathan,Aliona Zintiridou,Edward Nieves,Monika Dzieciatkowska,Julie A. Reisz,Evripidis Gavathiotis,Angelo D'Alessandro,Britta Will,Ana Maria Cuervo +14 more
TL;DR: The authors showed that chaperone-mediated autophagy, a selective form of lysosomal protein degradation, is involved in sustaining haematopoietic stem cells function in adult mice.
Journal ArticleDOI
HSC Niche Biology and HSC Expansion Ex Vivo
Sachin Kumar,Hartmut Geiger +1 more
TL;DR: Current knowledge of niche biology, the intrinsic regulators of HSC self-renewal in vivo, and novel niche-informed strategies of H SC expansion ex vivo are discussed and introduced.
Journal ArticleDOI
Stem cells and aging in the hematopoietic system.
Luigi Warren,Derrick J. Rossi +1 more
TL;DR: With age, HSCs show an increased propensity to differentiate towards myeloid rather than lymphoid lineages, which may contribute to the decline in lymphopoiesis that attends aging.
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