Extracellular vesicles tell all: How vesicle-mediated cellular communication shapes hematopoietic stem cell biology with increasing age
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TLDR
In this article, a review summarizes the current literature dealing with how age-altered intercellular communication mediated by Extracellular Vesicles (EVs) influences HSC biology.About:
This article is published in Experimental Hematology.The article was published on 2021-09-01 and is currently open access. It has received 1 citations till now. The article focuses on the topics: Vesicle.read more
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Spinal cord injury reprograms muscle fibro-adipogenic progenitors to formheterotopic bones within muscles
Hsu-Wen Tseng,Dorothée Girard,Kylie A. Alexander,Susan M. Millard,Frédéric Torossian,Adrienne Anginot,Whitney Fleming,Jules Gueguen,M.-E. Goriot,Denis Clay,Beulah Jose,B. Nowlan,Allison R. Pettit,Marjorie Salga,François Genêt,M.-C. Bousse-Kerdiles,Sébastien Banzet,Jean-Pierre Levesque +17 more
TL;DR: The cells-of-origin of neurogenic heterotopic ossifications (NHO), which develop frequently in the periarticular muscles following spinal cord injuries (SCI) and traumatic brain injuries, remain unclear because the skeletal muscle harbors two progenitor cell populations: satellite cells (SCs) and fibro-adipogenic progenitors (FAPs) which are mesenchymal.
References
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Journal ArticleDOI
Autophagy maintains the metabolism and function of young and old stem cells
Theodore T. Ho,Matthew R. Warr,Emmalee R. Adelman,Olivia M. Lansinger,Johanna Flach,Evgenia Verovskaya,Maria E. Figueroa,Emmanuelle Passegué +7 more
TL;DR: It is demonstrated that autophagy actively suppresses haematopoietic stem-cell metabolism by clearing active, healthy mitochondria to maintain quiescence and stemness, and becomes increasingly necessary with age to preserve the regenerative capacity of old haematic stem cells.
Journal ArticleDOI
Phosphatidylserine (PS) induces PS receptor–mediated macropinocytosis and promotes clearance of apoptotic cells
Peter R. Hoffmann,Aimee deCathelineau,Carol Anne Ogden,Yann Leverrier,Donna L. Bratton,David L. Daleke,Anne J. Ridley,Valerie A. Fadok,Peter M. Henson +8 more
TL;DR: The results suggest that regardless of the receptors engaged on the phagocyte, ingestion does not occur in the absence of phosphatidylserine (PS), and recognition of PS was found to be dependent on the presence of the PS receptor (PSR).
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A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes
Vincent Soubannier,Gian-Luca McLelland,Rodolfo Zunino,Emelie Braschi,Peter Rippstein,Edward A. Fon,Heidi M. McBride +6 more
TL;DR: A novel vesicle transport route between the mitochondria and lysosomes is characterized, providing insights into the basic mechanisms of mitochondrial quality control and suggesting that vesicles delivery complements mitophagy.
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Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection
TL;DR: This is the first report on the exosomal tetraspanin web contributing to target cell selection such that predictions can be made on potential targets, which will facilitate tailoring exosomes for drug delivery.
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Exosomes maintain cellular homeostasis by excreting harmful DNA from cells
Akiko Takahashi,Ryo Okada,Koji Nagao,Yuka Kawamata,Aki Hanyu,Shin Yoshimoto,Masaki Takasugi,Sugiko Watanabe,Masato T. Kanemaki,Chikashi Obuse,Eiji Hara,Eiji Hara,Eiji Hara +12 more
TL;DR: Results indicate that exosome secretion maintains cellular homeostasis by removing harmful cytoplasmic DNA from cells, and provide valuable new insights into the control of cellularHomeostasis.
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