Extracellular vesicles tell all: How vesicle-mediated cellular communication shapes hematopoietic stem cell biology with increasing age
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TLDR
In this article, a review summarizes the current literature dealing with how age-altered intercellular communication mediated by Extracellular Vesicles (EVs) influences HSC biology.About:
This article is published in Experimental Hematology.The article was published on 2021-09-01 and is currently open access. It has received 1 citations till now. The article focuses on the topics: Vesicle.read more
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Spinal cord injury reprograms muscle fibro-adipogenic progenitors to formheterotopic bones within muscles
Hsu-Wen Tseng,Dorothée Girard,Kylie A. Alexander,Susan M. Millard,Frédéric Torossian,Adrienne Anginot,Whitney Fleming,Jules Gueguen,M.-E. Goriot,Denis Clay,Beulah Jose,B. Nowlan,Allison R. Pettit,Marjorie Salga,François Genêt,M.-C. Bousse-Kerdiles,Sébastien Banzet,Jean-Pierre Levesque +17 more
TL;DR: The cells-of-origin of neurogenic heterotopic ossifications (NHO), which develop frequently in the periarticular muscles following spinal cord injuries (SCI) and traumatic brain injuries, remain unclear because the skeletal muscle harbors two progenitor cell populations: satellite cells (SCs) and fibro-adipogenic progenitors (FAPs) which are mesenchymal.
References
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Journal ArticleDOI
High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis
Laura Bouchareychas,Phat Duong,Tuan Anh Phu,Eric Alsop,Bessie Meechoovet,Rebecca Reiman,Martin Ng,Ryo Yamamoto,Hiromitsu Nakauchi,Warren J. Gasper,Warren J. Gasper,Kendall Van Keuren-Jensen,Robert L. Raffai,Robert L. Raffai +13 more
TL;DR: In this paper, extracellular vesicles (EVs) produced by bone marrow-derived macrophages (BMDM) exposed to high glucose (HG-exo) or control were investigated to drive atherosclerosis.
Journal ArticleDOI
Physiological Cues Involved in the Regulation of Adhesion Mechanisms in Hematopoietic Stem Cell Fate Decision.
TL;DR: The adhesion molecules involved in the regulation of HSCs are reviewed, and recent advances in the understanding of the physiological cues known to initiate specific adhesive interactions of H SCs with the marrow stromal cells or ECM molecules and EVs secreted by them are touched upon.
Journal ArticleDOI
Hijacking Endocytosis and Autophagy in Extracellular Vesicle Communication: Where the Inside Meets the Outside.
Giona Pedrioli,Paolo Paganetti +1 more
TL;DR: The role of the autophagic pathway and the endocytic pathway in the interaction between extracellular vesicle cargo proteins and its cytosolic target within the acidic compartments of the cell is discussed in this paper.
Journal ArticleDOI
Lysosomal Regulation of Metabolism in Quiescent Hematopoietic Stem Cells: More than Just Autophagy.
TL;DR: In this article, the depth of quiescence in hematopoietic stem cells (HSCs) dictates their potency and is sensitive to metabolic perturbations, and lysosomal functions distinct from autophagic processes are pivotal in regulating quiescent versus activation by potential control of the access to a nutrient reservoir required for HSC activation.
Journal ArticleDOI
Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age
Isabelle Grenier-Pleau,Kathrin Tyryshkin,Tri Dung Le,John F. Rudan,Eric Bonneil,Pierre Thibault,Karen Zeng,Cecilia Lässer,David Mallinson,Dimitrios A. Lamprou,Jialui Hui,Lynne-Marie Postovit,Lynne-Marie Postovit,Edmond Chan,Sheela A. Abraham +14 more
TL;DR: This study establishes for the first time that although EV particle size, concentration, and total protein content remain relatively consistent over an adult lifespan in humans, EV content evolves during aging and potentially influences HSC regulation.
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