Journal ArticleDOI
Fascin-1 as a biomarker and prospective therapeutic target in colorectal cancer.
TLDR
The status and key questions surrounding investigations of fascin-1 as a novel, early prognostic biomarker in colorectal cancer are discussed and ongoing pre-clinical research into new migration inhibitory and anti-metastatic compounds that alter the actin cytoskeleton are discussed.Abstract:
Fascin-1 is a filamentous actin-binding protein that crosslinks actin microfilaments into tight, parallel bundles. These bundles are important for the extension of microspikes, filopodia and invadopodia from cell surfaces and for the functionality of these protrusions in cell migration and/or dynamic sensing of the local microenvironment. Fascin-1 is absent in normal colonic epithelium, but its upregulation in colorectal adenomas and adenocarcinomas and its correlation with an aggressive clinical course has piqued the interest of many laboratories with research interests in cancer metastasis. This report summarizes current knowledge of the molecular interactions of fascin-1 in relation to its activities and mechanisms of upregulation in colorectal carcinoma cells. The status and key questions surrounding investigations of fascin-1 as a novel, early prognostic biomarker in colorectal cancer are discussed. Ongoing pre-clinical research into new migration inhibitory and anti-metastatic compounds that alter the actin cytoskeleton, and the goal of targeting fascin-1, is also discussed.read more
Citations
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Role of cellular cytoskeleton in epithelial-mesenchymal transition process during cancer progression (Review)
TL;DR: There are numerous advances in understanding of the fundamental role of the cytoskeleton in cancer cell invasion and migration, and the recent novel insights into the different cytos skeleton underlying EMT are summarized.
Journal ArticleDOI
Fascin Regulates Nuclear Movement and Deformation in Migrating Cells
Asier Jayo,Majid Malboubi,Susumu Antoku,Wakam Chang,Elena Ortiz-Zapater,Christopher M. Groen,Karin Pfisterer,Tina L. Tootle,Guillaume Charras,Gregg G. Gundersen,Madeline Parsons +10 more
TL;DR: A role for fascin that operates independently of filopodia assembly to promote efficient cell migration and invasion is uncovered.
Journal ArticleDOI
Cytoskeletal Remodeling in Cancer
TL;DR: Understanding the signaling mechanisms involved, will give a better insight of the changes during metastasis, which will eventually help targeting proteins for treatment resulting in reduced mortality and longer survival.
Journal ArticleDOI
Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis.
Arpita Datta,Shuo Deng,Vennila Gopal,Kenneth Chun-Hong Yap,Clarissa Esmeralda Halim,Mun Leng Lye,Mei Shan Ong,Tuan Zea Tan,Gautam Sethi,Shing Chuan Hooi,Alan Prem Kumar,Celestial T. Yap,Celestial T. Yap +12 more
TL;DR: In this article, a review summarizes the physiological functions of the cytoskeleton, its role in the epithelial to mesenchymal transition (EMT) process, and its effect on multidrug resistant (MDR) cancer cells.
Journal ArticleDOI
BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS-Mutant Colorectal Cancer.
Alice Bartolini,Sabrina Cardaci,Simona Lamba,Daniele Oddo,Caterina Marchiò,Paola Cassoni,Carla Azzurra Amoreo,Giorgio Corti,Alessandro Testori,Federico Bussolino,Renata Pasqualini,Wadih Arap,Davide Corà,Federica Di Nicolantonio,Serena Marchiò +14 more
TL;DR: Data show that the BCAM/LAMA5 system plays a functional role in the metastatic spreading of KRAS-mutant colorectal cancer by mediating tumor–TME interactions and as such represents a valuable therapeutic candidate for this large, currently untreatable patient group.
References
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