Open Access
Features, Evaluation and Treatment Coronavirus (COVID-19)
TLDR
The effects of the epidemic caused by the new CoV has yet to emerge as the situation is quickly evolving, and world governments are at work to establish countermeasures to stem possible devastating effects.Citations
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Development of a Multi-Dimensional Parametric Model With Non-Pharmacological Policies for Predicting the COVID-19 Pandemic Casualties
TL;DR: In this paper, the authors developed a suspicious-infected-death with non-pharmacological policies (SpID-N) model to analyze the properties of the COVID-19 casualties and also estimate the future behavior of the outbreak.
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Comparative analysis of human coronaviruses focusing on nucleotide variability and synonymous codon usage patterns.
Jayanta Kumar Das,Swarup Roy +1 more
TL;DR: In this paper, a comprehensive quantitative analysis of the protein-coding sequences of seven human coronaviruses (HCoVs) was performed to decipher the nucleotide sequence variability and codon usage patterns.
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Explainable Artificial Intelligence for COVID-19 Diagnosis Through Blood Test Variables
Lucas M. Thimoteo,Marley M. B. R. Vellasco,Jorge Cunha de Sequeira Amaral,Karla Figueiredo,Cátia Lie Yokoyama,Erito Marques +5 more
TL;DR: Wang et al. as mentioned in this paper proposed an explainable artificial intelligence approach to diagnose COVID-19 patients based on blood test and pathogen variables, which achieved an AUC of 0.87.
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A comparative analysis of the Spanish Flu 1918 and COVID-19 pandemics
Akhilesh Agrawal,Aadesh Gindodiya,Kaivalya A. Deo,Supriya Kashikar,Punit Fulzele,Nazli Khatib +5 more
TL;DR: To contain the spread of COVID-19 and to prevent the situation which happened a century back, it becomes essential to examine and correlate these pandemics in terms of their origin, epidemiology and clinical scenario.
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SARS-CoV-2: phenotype, genotype, and characterization of different variants
Mohammadreza Saberiyan,Elham Karimi,Zahra Khademi,Parvaneh Movahhed,Amir Safi,Ameneh Mehri-Ghahfarrokhi +5 more
TL;DR: In this article , seven SARS-CoV-2 subtypes have received the most attention, with the World Health Organization (WHO) naming 11 of them and the remaining six are either being monitored or are no longer considered a threat.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
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Acute respiratory distress syndrome: the Berlin Definition.
Ards Definition Task Force,V. Marco Ranieri,Gordon D. Rubenfeld,B. Taylor Thompson,Niall D. Ferguson,Ellen Caldwell,Eddy Fan,Luigi Camporota,Luigi Camporota,Arthur S. Slutsky +9 more
TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
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Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1.
Neeltje van Doremalen,Trenton Bushmaker,Dylan H. Morris,Myndi G. Holbrook,Amandine Gamble,Brandi N. Williamson,Azaibi Tamin,Jennifer L Harcourt,Natalie J. Thornburg,Susan I. Gerber,James O. Lloyd-Smith,Emmie de Wit,Vincent J. Munster +12 more
TL;DR: Aerosol and Surface Stability of SARS-CoV-2 In this research letter, investigators report on the stability of Sars-CoVs and the viability of the two virus under experimental conditions.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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