Open Access
Features, Evaluation and Treatment Coronavirus (COVID-19)
TLDR
The effects of the epidemic caused by the new CoV has yet to emerge as the situation is quickly evolving, and world governments are at work to establish countermeasures to stem possible devastating effects.Citations
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Virtual screening of anti-HIV1 compounds against SARS-CoV-2: machine learning modeling, chemoinformatics and molecular dynamics simulation based analysis.
Mahesha Nand,Priyanka Maiti,Tushar Joshi,Subhash Chandra,Veena Pande,Jagdish Chandra Kuniyal,Muthannan Andavar Ramakrishnan +6 more
TL;DR: 2 out of 1528 compounds were screened as potential hits against 3CLpro which could be further treated as an excellent drug against SARS-CoV-2.
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Six artificial intelligence paradigms for tissue characterisation and classification of non-COVID-19 pneumonia against COVID-19 pneumonia in computed tomography lungs.
Luca Saba,Mohit Agarwal,Anubhav Patrick,Anudeep Puvvula,Suneet K. Gupta,Alessandro Carriero,John R. Laird,George D. Kitas,George D. Kitas,Amer M. Johri,Antonella Balestrieri,Zeno Falaschi,Alessio Paschè,Vijay Viswanathan,Ayman El-Baz,Iqbal Alam,Abhinav Jain,D. Subbaram Naidu,Ronald Oberleitner,Narendra N. Khanna,Arindam Bit,Mostafa Fatemi,Azra Alizad,Jasjit S. Suri +23 more
TL;DR: In this article, six models, two traditional machine learning (ML)-based (k-NN and RF), two transfer learning (TL-based (VGG19 and InceptionV3), and the last two were our custom-designed deep learning (DL) models (CNN and iCNN) were developed for classification between COVID pneumonia and non-COVID pneumonia (NCoP) and K10 cross-validation (90% training: 10% testing) protocol on an Italian cohort of 100 COP and 30 NCoP patients was used for performance evaluation and
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SARS-CoV-2-mediated immune system activation and potential application in immunotherapy.
Yuan Tan,Faqin Tang +1 more
TL;DR: In this review, the development of a SARS‐CoV‐2‐specific vaccine based on the analysis of epitopes is emphatically illuminated, also expounding the molecular mechanisms of SARS •CoV •2‐mediated cytokine release syndrome.
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Accelerated Preclinical Paths to Support Rapid Development of COVID-19 Therapeutics.
Jay A. Grobler,Annaliesa S. Anderson,Prabhavathi Fernandes,Michael S. Diamond,Christine M. Colvis,Joseph P. Menetski,Rosa M. Alvarez,John A. T. Young,Kara Carter +8 more
TL;DR: The minimum data package required to move a compound into clinical development safely is proposed and the additional data that should be collected in parallel without impacting the rapid path to clinical development is defined.
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Immunocytometric analysis of COVID patients: A contribution to personalized therapy?
Sara Cacciapuoti,Annunziata De Rosa,Monica Gelzo,Matteo Megna,Maddalena Raia,Biagio Pinchera,Agostina Pontarelli,Riccardo Scotto,Emanuele Scala,Francesco Scarano,Giulia Scalia,Giuseppe Castaldo,Gabriella Fabbrocini,Ivan Gentile,Roberto Parrella +14 more
TL;DR: Cytofluorimetry revealed a functional exhaustion of most lymphocyte populations in COVID patients not involving activated TH1 and TH17, and suggested that some patients could benefit from monoclonal antibodies treatment targeting IL-17 pathway.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
Journal ArticleDOI
Acute respiratory distress syndrome: the Berlin Definition.
Ards Definition Task Force,V. Marco Ranieri,Gordon D. Rubenfeld,B. Taylor Thompson,Niall D. Ferguson,Ellen Caldwell,Eddy Fan,Luigi Camporota,Luigi Camporota,Arthur S. Slutsky +9 more
TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
Journal ArticleDOI
Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1.
Neeltje van Doremalen,Trenton Bushmaker,Dylan H. Morris,Myndi G. Holbrook,Amandine Gamble,Brandi N. Williamson,Azaibi Tamin,Jennifer L Harcourt,Natalie J. Thornburg,Susan I. Gerber,James O. Lloyd-Smith,Emmie de Wit,Vincent J. Munster +12 more
TL;DR: Aerosol and Surface Stability of SARS-CoV-2 In this research letter, investigators report on the stability of Sars-CoVs and the viability of the two virus under experimental conditions.
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