Open Access
Features, Evaluation and Treatment Coronavirus (COVID-19)
TLDR
The effects of the epidemic caused by the new CoV has yet to emerge as the situation is quickly evolving, and world governments are at work to establish countermeasures to stem possible devastating effects.Citations
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Biosafety measures for preventing infection from COVID-19 in clinical laboratories: IFCC Taskforce Recommendations.
Giuseppe Lippi,Khosrow Adeli,Maurizio Ferrari,Andrea R. Horvath,David Koch,Sunil Sethi,Cheng Bin Wang +6 more
TL;DR: It is believed that the interim measures proposed in this document for best practice will help minimazing the risk of developing COVID-19 while working in clinical laboratories.
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Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key?
Simone Meini,Andrea Zanichelli,Rodolfo Sbrojavacca,Federico Iuri,Anna Teresa Roberts,Chiara Suffritti,Carlo Tascini +6 more
TL;DR: A complex host response to SARS-CoV-2 is hypothesized, with the Contact System (CS) playing a pivotal role in innate immune response, and therapies targeting the CS, the KKS and action of BK could be effective for the treatment of COVID-19.
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Host transcriptome-guided drug repurposing for COVID-19 treatment: a meta-analysis based approach
Tamizhini Loganathan,Srimathy Ramachandran,Prakash Shankaran,Devipriya Nagarajan,Suma Mohan S +4 more
TL;DR: A host transcriptome-based drug repurposing strategy utilizing the publicly available high throughput gene expression data on SARS-CoV-2 and other respiratory infection viruses could suggest six approved PTGS2 inhibitor drugs for the treatment of COVID-19.
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The impacts of the built environment on the incidence rate of COVID-19: A case study of King County, Washington.
Chao Liu,Zerun Liu,ChengHe Guan +2 more
TL;DR: This article assessed the impact of the built environment on the incidence rate in King County, US and explored methods of researching infectious diseases in urban areas using principal component analysis and the Pearson correlation coefficient to process the data and built multiple linear regression and geographically weighted regression models at the ZIP code scale.
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N95 Mask Reuse in a Major Urban Hospital - COVID-19 Response Process and Procedure.
Michael P. Czubryt,Taras Stecy,Eddie Popke,Randy M. Aitken,Kim Jabusch,Richard Pound,Peter Lawes,Bram Ramjiawan,Grant N. Pierce +8 more
TL;DR: It is shown that daily wear substantially reduces NRM fit, limiting reuse to a single cycle, but still increasing NRM stocks by ∼66%, suggesting reuse is feasible in major hospitals and other healthcare facilities.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
Journal ArticleDOI
Acute respiratory distress syndrome: the Berlin Definition.
Ards Definition Task Force,V. Marco Ranieri,Gordon D. Rubenfeld,B. Taylor Thompson,Niall D. Ferguson,Ellen Caldwell,Eddy Fan,Luigi Camporota,Luigi Camporota,Arthur S. Slutsky +9 more
TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
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Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1.
Neeltje van Doremalen,Trenton Bushmaker,Dylan H. Morris,Myndi G. Holbrook,Amandine Gamble,Brandi N. Williamson,Azaibi Tamin,Jennifer L Harcourt,Natalie J. Thornburg,Susan I. Gerber,James O. Lloyd-Smith,Emmie de Wit,Vincent J. Munster +12 more
TL;DR: Aerosol and Surface Stability of SARS-CoV-2 In this research letter, investigators report on the stability of Sars-CoVs and the viability of the two virus under experimental conditions.
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