Open Access
Features, Evaluation and Treatment Coronavirus (COVID-19)
TLDR
The effects of the epidemic caused by the new CoV has yet to emerge as the situation is quickly evolving, and world governments are at work to establish countermeasures to stem possible devastating effects.Citations
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COVID-19 and the elderly with chronic diseases: Narrative review
TL;DR: elderly people with COVID-19, and with a history of chronic diseases have a more severe form of respiratory distress syndrome than other people withCOVID- 19, which can lead to death Regardless of the severity of the disease, supportive care for patients is essential.
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Public knowledge, attitude and practice regarding home quarantine to prevent COVID-19 in Sabzevar city, Iran
Arezoo Fallahi,Neda Mahdavifar,Alireza Ghorbani,Parisa Mehrdadian,Ali Mehri,Hamid Joveini,Reza Shahrabadi +6 more
TL;DR: People's practice regarding home quarantine to prevent COVID-19 depends on a number of factors and paying attention to the gender, attitude and occupation of individuals in policy making regarding homearantine can improve the performance of the public.
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Knowledge, attitude and practice (KAP) towards COVID-19 prevention among malaysian adults during the period of movement control order (mco): An online cross-sectional survey
Nadeeya ‘Ayn Umaisara Mohamad Nor,Hana Maizuliana Solehan,Nurul Azmawati Mohamed,Zatul Iffah Abu Hasan,Nur Syazana Umar,Suhaila Sanip,Mohd Dzulkhairi Mohd Rani +6 more
TL;DR: In this paper, a study was conducted among 1,543 Malaysian adults using a validated questionnaire to explore more findings on the Malaysian's knowledge, attitude and practice (KAP) level towards COVID-19 prevention during the MCO period.
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New putative insights into neprilysin (NEP)-dependent pharmacotherapeutic role of roflumilast in treating COVID-19.
TL;DR: This review thoroughly discusses the proposed NEP-based therapeutic properties of roflumilast, which may be of great importance in curing COVID-19, but further clinical studies are required to confirm this strategy and to evaluate its in vivo preventive and therapeutic efficacy.
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COVID-19: Implications for bipolar disorder clinical care and research
Siqi Xue,M. Ishrat Husain,M. Ishrat Husain,Abigail Ortiz,Abigail Ortiz,M. Omair Husain,M. Omair Husain,Zafiris J. Daskalakis,Zafiris J. Daskalakis,Benoit H. Mulsant,Benoit H. Mulsant +10 more
TL;DR: Without special intervention, individuals with bipolar disorder will experience poorer physical and mental health outcomes due to interplay of patient, provider and societal factors, and mitigation strategies are proposed, focusing on digital medicine strategies to improve quality of and accessibility to service.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
Journal ArticleDOI
Acute respiratory distress syndrome: the Berlin Definition.
Ards Definition Task Force,V. Marco Ranieri,Gordon D. Rubenfeld,B. Taylor Thompson,Niall D. Ferguson,Ellen Caldwell,Eddy Fan,Luigi Camporota,Luigi Camporota,Arthur S. Slutsky +9 more
TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
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Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1.
Neeltje van Doremalen,Trenton Bushmaker,Dylan H. Morris,Myndi G. Holbrook,Amandine Gamble,Brandi N. Williamson,Azaibi Tamin,Jennifer L Harcourt,Natalie J. Thornburg,Susan I. Gerber,James O. Lloyd-Smith,Emmie de Wit,Vincent J. Munster +12 more
TL;DR: Aerosol and Surface Stability of SARS-CoV-2 In this research letter, investigators report on the stability of Sars-CoVs and the viability of the two virus under experimental conditions.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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