Open Access
Features, Evaluation and Treatment Coronavirus (COVID-19)
TLDR
The effects of the epidemic caused by the new CoV has yet to emerge as the situation is quickly evolving, and world governments are at work to establish countermeasures to stem possible devastating effects.Citations
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Preexisting comorbidities predicting severe covid-19 in older adults in the uk biobank community cohort
Janice L. Atkins,Jane A. H. Masoli,Jane A. H. Masoli,João Delgado,Luke C. Pilling,Luke C. Pilling,Chia-Ling Kuo,George A. Kuchel,David Melzer,David Melzer +9 more
TL;DR: Tailored interventions may be needed, as these results do not support simple age-based targeting to prevent severe COVID-19 infection, and specific co-morbidities are disproportionally common in older adults who develop severe CO VID-19.
Journal ArticleDOI
Modes of Transmission of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) and Factors Influencing on the Airborne Transmission: A Review.
TL;DR: In this paper, different databases are reviewed to evaluate modes of transmission of SARS-CoV-2 and study the effects of negative pressure ventilation, air conditioning system, and related protection approaches of this virus.
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Comprehensive Review on Current Interventions, Diagnostics, and Nanotechnology Perspectives against SARS-CoV-2.
Deepak S. Chauhan,Rajendra Prasad,Rohit Srivastava,Meena Jaggi,Subhash C. Chauhan,Murali M. Yallapu +5 more
TL;DR: In this paper, a review summarizes the recent involvement of nanotechnology from the development of a biosensor to fabrication of a multifunctional nanohybrid system for respiratory and deadly viruses, along with the recent interventions and current understanding about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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A Mechanistic Link Between Selenium and Coronavirus Disease 2019 (COVID-19).
Saroj Khatiwada,Astha Subedi +1 more
TL;DR: Zhang et al. as discussed by the authors examined the current evidence on the role of selenium in COVID-19, and found that selenIUM deficiency is related to oxidative stress and hyperinflammation seen in critical illness.
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A machine learning based exploration of COVID-19 mortality risk.
Mahdi Mahdavi,Mahdi Mahdavi,Hadi Choubdar,Hadi Choubdar,Erfan Zabeh,Michael J. Rieder,Safieddin Safavi-Naeini,Zsolt Jobbagy,Amirata Ghorbani,Atefeh Abedini,Arda Kiani,Vida Khanlarzadeh,Reza Lashgari,Ehsan Kamrani,Ehsan Kamrani +14 more
TL;DR: In this paper, three Support Vector Machine (SVM) models were developed and compared using invasive, non-invasive, and both groups of features, and the results suggested that noninvasive features could provide mortality predictions that are similar to the invasive and roughly on par with the joint model.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
Journal ArticleDOI
Acute respiratory distress syndrome: the Berlin Definition.
Ards Definition Task Force,V. Marco Ranieri,Gordon D. Rubenfeld,B. Taylor Thompson,Niall D. Ferguson,Ellen Caldwell,Eddy Fan,Luigi Camporota,Luigi Camporota,Arthur S. Slutsky +9 more
TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
Journal ArticleDOI
Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1.
Neeltje van Doremalen,Trenton Bushmaker,Dylan H. Morris,Myndi G. Holbrook,Amandine Gamble,Brandi N. Williamson,Azaibi Tamin,Jennifer L Harcourt,Natalie J. Thornburg,Susan I. Gerber,James O. Lloyd-Smith,Emmie de Wit,Vincent J. Munster +12 more
TL;DR: Aerosol and Surface Stability of SARS-CoV-2 In this research letter, investigators report on the stability of Sars-CoVs and the viability of the two virus under experimental conditions.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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