Open Access
Features, Evaluation and Treatment Coronavirus (COVID-19)
TLDR
The effects of the epidemic caused by the new CoV has yet to emerge as the situation is quickly evolving, and world governments are at work to establish countermeasures to stem possible devastating effects.Citations
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Endothelial Dysfunction in COVID-19: Potential Mechanisms and Possible Therapeutic Options
Maria Chiara Pelle,Isabella Zaffina,S. Lucà,Valentina Forte,V. Trapanese,Melania Melina,F Giofré,Franco Arturi +7 more
TL;DR: Considering the crucial role of the immunological response and endothelial damage in developing the severe form of COVID-19, this review will attempt to clarify the underlying pathophysiological mechanisms.
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A multivariate analysis of risk factors associated with death by Covid-19 in the USA, Italy, Spain, and Germany.
Alexandre de Fátima Cobre,Beatriz Böger,Raquel de Oliveira Vilhena,Mariana Millan Fachi,Josiane Marlei Muller Fernandes dos Santos,Fernanda S. Tonin +5 more
TL;DR: Investments in hospitals’ infrastructure, as well as the development of innovative devices for patient’s ventilation, are paramount to fight the pandemic in the USA, Italy, Spain, and Germany.
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Potential Antiviral Activity of Lactiplantibacillus plantarum KAU007 against Influenza Virus H1N1
TL;DR: It is reinforced that camel milk contains beneficial LAB isolates with antagonistic properties against the H1N1 influenza virus, and CFCS at 5 and 10 mg/mL significantly decreased the level of IFN-γ and IL-6 in a dose-dependent manner.
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Risk perception and knowledge of COVID-19 in patients with celiac disease.
Jamie Zhen,Juan Pablo Stefanolo,María de la Paz Temprano,Caroline L Seiler,Alberto Caminero,Enrique de-Madaria,Miguel Montoro Huguet,Vivas Santiago,Sonia I. Niveloni,E. Smecuol,Luis Uzcanga Dominguez,Elena Trucco,Virginia López,Carolina Olano,Pasquale Mansueto,Antonio Carroccio,Peter H.R. Green,Donald R. Duerksen,Andrew S. Day,Jason A. Tye-Din,Julio C. Bai,Carolina Ciacci,Elena F. Verdu,Benjamin Lebwohl,M Ines Pinto-Sanchez +24 more
TL;DR: In this article, the authors investigated risk perceptions of contracting COVID-19 in patients with celiac disease and determined the factors that may influence their perception, such as age, sex, adherence to a gluten-free diet, and comorbidities such as cardiac conditions, respiratory conditions, and diabetes.
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Impact of Underlying Comorbidities on Mortality in SARS-COV-2 Infected Cancer Patients: A Systematic Review and Meta-Analysis
TL;DR: In this article, the authors explored the prevalence of comorbidities among cancer patients with SARS CoV-2 infection and their impact on mortality, and found that the mortality in SARS-CoV2 infected cancer patients is affected by preexisting non-cancer comorbiities.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
Journal ArticleDOI
Acute respiratory distress syndrome: the Berlin Definition.
Ards Definition Task Force,V. Marco Ranieri,Gordon D. Rubenfeld,B. Taylor Thompson,Niall D. Ferguson,Ellen Caldwell,Eddy Fan,Luigi Camporota,Luigi Camporota,Arthur S. Slutsky +9 more
TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
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Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1.
Neeltje van Doremalen,Trenton Bushmaker,Dylan H. Morris,Myndi G. Holbrook,Amandine Gamble,Brandi N. Williamson,Azaibi Tamin,Jennifer L Harcourt,Natalie J. Thornburg,Susan I. Gerber,James O. Lloyd-Smith,Emmie de Wit,Vincent J. Munster +12 more
TL;DR: Aerosol and Surface Stability of SARS-CoV-2 In this research letter, investigators report on the stability of Sars-CoVs and the viability of the two virus under experimental conditions.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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