Open Access
Features, Evaluation and Treatment Coronavirus (COVID-19)
TLDR
The effects of the epidemic caused by the new CoV has yet to emerge as the situation is quickly evolving, and world governments are at work to establish countermeasures to stem possible devastating effects.Citations
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Journal ArticleDOI
An inflammatory cytokine signature predicts COVID-19 severity and survival.
Diane Marie Del Valle,Seunghee Kim-Schulze,Hsin-Hui Huang,Noam D. Beckmann,Sharon Nirenberg,Bo Wang,Yonit Lavin,Talia H. Swartz,Deepu Madduri,Aryeh Stock,Thomas U. Marron,Hui Xie,Manishkumar Patel,Kevin Tuballes,Oliver Van Oekelen,Adeeb Rahman,Patricia Kovatch,Judith A. Aberg,Eric E. Schadt,Sundar Jagannath,Madhu Mazumdar,Alexander W. Charney,Adolfo Firpo-Betancourt,Damodara Rao Mendu,Jeffrey S. Jhang,David Reich,Keith Sigel,Carlos Cordon-Cardo,Marc Feldmann,Samir Parekh,Miriam Merad,Sacha Gnjatic +31 more
TL;DR: It is proposed that serum IL-6 and TNF-α levels should be considered in the management and treatment of patients with COVID-19 to stratify prospective clinical trials, guide resource allocation and inform therapeutic options.
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Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study.
Lei Pan,Lei Pan,Mi Mu,Pengcheng Yang,Yu Sun,Runsheng Wang,Junhong Yan,Pibao Li,Baoguang Hu,Jing Wang,Chao Hu,Yuan Jin,Xun Niu,Rongyu Ping,Yingzhen Du,Tianzhi Li,Guogang Xu,Qinyong Hu,Lei Tu +18 more
TL;DR: It is found that digestive symptoms are common in patients with COVID-19 and that the index of suspicion may need to be raised earlier in at-risk patients presenting with digestive symptoms, but further large sample studies are needed to confirm these findings.
Journal ArticleDOI
Coronavirus Disease 2019–COVID-19
Kuldeep Dhama,Khan Sharun,Ruchi Tiwari,Shubhankar Sircar,Sudipta Bhat,Yashpal Singh Malik,Karam Pal Singh,Wanpen Chaicumpa,D. Katterine Bonilla-Aldana,Alfonso J. Rodriguez-Morales +9 more
TL;DR: Analysis of epidemiological, diagnostic, clinical, and therapeutic aspects, including perspectives of vaccines and preventive measures that have already been globally recommended to counter this pandemic virus, suggest that this novel virus has been transferred from an animal source, such as bats.
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"Pandemic fear" and COVID-19: mental health burden and strategies.
TL;DR: ‘‘Pandemic fear’’ and COVID-19: mental health burden and strategies
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A Comprehensive Review of the COVID-19 Pandemic and the Role of IoT, Drones, AI, Blockchain, and 5G in Managing its Impact
TL;DR: The use of technologies such as the Internet of Things (IoT), Unmanned Aerial Vehicles (UAVs), blockchain, Artificial Intelligence (AI), and 5G, among others, are explored to help mitigate the impact of COVID-19 outbreak.
References
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Journal ArticleDOI
Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial.
Ling Li,Zhang Wei,Yu Hu,Xunliang Tong,Shangen Zheng,Juntao Yang,Yujie Kong,Lili Ren,Qing Wei,Heng Mei,Caiying Hu,Cuihua Tao,Ru Yang,Jue Wang,Yongpei Yu,Guo Yong,Xiaoxiong Wu,Zhihua Xu,Li Zeng,Nian Xiong,Lifeng Chen,Juan Wang,Ning Man,Yu Liu,Haixia Xu,E. Deng,Xuejun Zhang,Chenyue Li,Conghui Wang,Shisheng Su,Linqi Zhang,Jianwei Wang,Yanyun Wu,Zhong Liu +33 more
TL;DR: Among patients with severe or life-threatening COVID-19, convalescent plasma therapy added to standard treatment, compared with standard treatment alone, did not result in a statistically significant improvement in time to clinical improvement within 28 days.
Journal ArticleDOI
Coronavirus Disease 2019 Case Surveillance - United States, January 22-May 30, 2020.
Erin K. Stokes,Laura D. Zambrano,Kayla N. Anderson,Ellyn P. Marder,Kala M. Raz,Suad El Burai Felix,Yunfeng Tie,Kathleen E. Fullerton +7 more
TL;DR: The COVID-19 pandemic continues to be severe, particularly in certain population groups, and the need to build on current efforts to collect and analyze case data, especially among those with underlying health conditions is underscored.
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Remdesivir for 5 or 10 Days in Patients with Severe Covid-19.
Jason D Goldman,David C. Lye,David S.C. Hui,Kristen M. Marks,Raffaele Bruno,Rocio Montejano,Christoph D. Spinner,Massimo Galli,Mi Young Ahn,Ronald Nahass,Yao Shen Chen,Devi SenGupta,Robert H. Hyland,Anu Osinusi,Huyen Cao,Christiana Blair,Xuelian Wei,Anuj Gaggar,Diana M. Brainard,William J. Towner,Jose Muñoz,Kathleen M. Mullane,Francisco M. Marty,Karen T. Tashima,George A. Diaz,Aruna Subramanian +25 more
TL;DR: In patients with severe Covid-19 not requiring mechanical ventilation, a randomized, open-label, phase 3 trial involving hospitalized patients with confirmed SARS-CoV-2 infection, oxygen saturation of 94% or less while they were breathing ambient air, and radiologic evidence of pneumonia, the magnitude of benefit cannot be determined.
Journal ArticleDOI
Efficacy of Tocilizumab in Patients Hospitalized with Covid-19.
John H. Stone,Matthew J. Frigault,Naomi Serling-Boyd,Ana D. Fernandes,Liam Harvey,Andrea S. Foulkes,Nora Horick,Brian C. Healy,Ruta Shah,Ana Maria Bensaci,Ann E. Woolley,Sarah Nikiforow,Nina Lin,Manish Sagar,Harry M Schrager,David S. Huckins,Matthew Axelrod,Michael D. Pincus,Jorge Fleisher,Chana A. Sacks,Michael Dougan,Crystal M. North,Yuan Di C. Halvorsen,Tara K. Thurber,Zeina Dagher,Allison K. Scherer,Rachel Wallwork,Arthur Y. Kim,Sara R. Schoenfeld,Pritha Sen,Tomas G. Neilan,Cory A. Perugino,Sebastian Unizony,Deborah S. Collier,Mark Matza,Janeth Yinh,Kathryn Bowman,Eric A. Meyerowitz,Amna Zafar,Zsofia D. Drobni,Marcy B. Bolster,Minna J. Kohler,Kristin M. D’Silva,Jonathan Dau,Megan Lockwood,Caroline Cubbison,Brittany Weber,Michael K. Mansour +47 more
TL;DR: Tocilizumab was not effective for preventing intubation or death in moderately ill hospitalized patients with Covid-19, and some benefit or harm cannot be ruled out, however, because the confidence intervals for efficacy comparisons were wide.
Journal ArticleDOI
Severe Covid-19
TL;DR: Key Clinical Points Evaluation and Management of Severe Covid-19 Patients with severe coronavirus disease 2019 (Covid- 19) may become critically ill with acute respiratory distress syndrome that typ...
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