Open Access
Features, Evaluation and Treatment Coronavirus (COVID-19)
TLDR
The effects of the epidemic caused by the new CoV has yet to emerge as the situation is quickly evolving, and world governments are at work to establish countermeasures to stem possible devastating effects.Citations
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Epidemiological, socio-demographic and clinical features of the early phase of the COVID-19 epidemic in Ecuador
Esteban Ortiz-Prado,Katherine Simbaña-Rivera,Ana Maria Diaz,Alejandra Barreto,Carla E Moyano,Vanessa Arcos,Eduardo Vásconez-González,Clara Paz,Fernanda Simbana-Guaycha,Martin Molestina-Luzuriaga,Raul Fernandez-Naranjo,javier Feijoo,Aquiles Rodrigo Henriquez,Lila Adana,Andrés López-Cortés,Isabel K. Fletcher,Rachel Lowe,Lenin Gómez-Barreno +17 more
TL;DR: It is shown that men are at higher risk of dying from COVID-19 than women, which increases as with age and the presence of comorbidities, and cantons located above 2,500 m have lower attack and mortality rates although the risk of Dying is greater among highlanders.
Journal ArticleDOI
Effect of COVID-19 on platelet count and its indices
Ertugrul Guclu,Havva Kocayigit,Hüseyin Doğuş Okan,Unal Erkorkmaz,Yusuf Yürümez,Selcuk Yaylaci,Mehmet Koroglu,Cem Uzun,Oguz Karabay +8 more
TL;DR: The findings revealed that oxygen saturation at admission and the MPV difference between the first and third days of hospitalization were significant parameters in COVID-19 patients for predicting mortality.
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Oxidative Stress Associated with SARS-Cov-2 (COVID-19) Increases the Severity of the Lung Disease - A Systematic Review
TL;DR: It is concluded that oxidative stress is a major factor increasing the severity of COVID-19 especially during chronic diseases associated with the fragility of the antioxidant system, suggesting to recommend antioxidants supplementation in therapeutic strategies against CO VID-19.
Journal ArticleDOI
The current understanding and potential therapeutic options to combat COVID-19.
TL;DR: The current review focused on possible therapeutic options such as repurposing drugs including antimalarials, antivirals, antiparasitic drugs, and anti-HIV drugs, as well as monoclonal antibodies, vaccines as potential treatment options.
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Convalescent Plasma: Therapeutic Hope or Hopeless Strategy in the SARS-CoV-2 Pandemic.
H. Cliff Sullivan,John D. Roback +1 more
TL;DR: The concluding sections of this review address the potential use of convalescent plasma during the present-day SARS-CoV-2 pandemic, not only insofar as its clinical benefit but also the steps required to make convalescence plasma treatments readily available for an exponentially growing patient population.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
Journal ArticleDOI
Acute respiratory distress syndrome: the Berlin Definition.
Ards Definition Task Force,V. Marco Ranieri,Gordon D. Rubenfeld,B. Taylor Thompson,Niall D. Ferguson,Ellen Caldwell,Eddy Fan,Luigi Camporota,Luigi Camporota,Arthur S. Slutsky +9 more
TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
Journal ArticleDOI
Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1.
Neeltje van Doremalen,Trenton Bushmaker,Dylan H. Morris,Myndi G. Holbrook,Amandine Gamble,Brandi N. Williamson,Azaibi Tamin,Jennifer L Harcourt,Natalie J. Thornburg,Susan I. Gerber,James O. Lloyd-Smith,Emmie de Wit,Vincent J. Munster +12 more
TL;DR: Aerosol and Surface Stability of SARS-CoV-2 In this research letter, investigators report on the stability of Sars-CoVs and the viability of the two virus under experimental conditions.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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