Finger millet bran supplementation alleviates obesity-induced oxidative stress, inflammation and gut microbial derangements in high-fat diet-fed mice
Nida Murtaza,Ritesh K. Baboota,Sneha Jagtap,Dhirendra Pratap Singh,Pragyanshu Khare,Siddhartha M. Sarma,Koteswaraiah Podili,Subramanian Alagesan,T. S. Chandra,Kamlesh K. Bhutani,Ravneet K. Boparai,Mahendra Bishnoi,Kanthi Kiran Kondepudi +12 more
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FM-BR supplementation could be an effective strategy for preventing high-fat diet-induced changes and developing FM-BR-enriched functional foods.Abstract:
Several epidemiological studies have shown that the consumption of finger millet (FM) alleviates diabetes-related complications. In the present study, the effect of finger millet whole grain (FM-WG) and bran (FM-BR) supplementation was evaluated in high-fat diet-fed LACA mice for 12 weeks. Mice were divided into four groups: control group fed a normal diet (10 % fat as energy); a group fed a high-fat diet; a group fed the same high-fat diet supplemented with FM-BR; a group fed the same high-fat diet supplemented with FM-WG. The inclusion of FM-BR at 10 % (w/w) in a high-fat diet had more beneficial effects than that of FM-WG. FM-BR supplementation prevented body weight gain, improved lipid profile and anti-inflammatory status, alleviated oxidative stress, regulated the expression levels of several obesity-related genes, increased the abundance of beneficial gut bacteria (Lactobacillus, Bifidobacteria and Roseburia) and suppressed the abundance of Enterobacter in caecal contents (P≤ 0·05). In conclusion, FM-BR supplementation could be an effective strategy for preventing high-fat diet-induced changes and developing FM-BR-enriched functional foods.read more
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Roseburia spp.: a marker of health?
Zohreh Tamanai-Shacoori,Imen Smida,Latifa Bousarghin,Olivier Loréal,Vincent Meuric,Vincent Meuric,Shao Bing Fong,Martine Bonnaure-Mallet,Martine Bonnaure-Mallet,Anne Jolivet-Gougeon,Anne Jolivet-Gougeon +10 more
TL;DR: The genus Roseburia consists of obligate Gram-positive anaerobic bacteria that are slightly curved, rod-shaped and motile by means of multiple subterminal flagella, affecting colonic motility, immunity maintenance and anti-inflammatory properties.
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Nutraceutical Value of Finger Millet [Eleusine coracana (L.) Gaertn.], and Their Improvement Using Omics Approaches.
Anil Kumar,Mamta Metwal,Sanveen Kaur,Atul Gupta,Swati Puranik,Sadhna Singh,Manoj Singh,Supriya Gupta,B. K. Babu,Salej Sood,Rattan Yadav +10 more
TL;DR: The role that recent biotechnological advancements have to offer for enrichment of finger millet's nutritional value are highlighted and how these developments can commission to the field of nutritional biology by opening new avenues for future research are highlighted.
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Whole cereal grains and potential health effects: Involvement of the gut microbiota
TL;DR: The scientific evidence supporting the hypothesis that WCGs prevent MetS by modulating gut microbiota composition and functions are discussed, with focuses on cereal intake-related mechanisms by which gut microbiota contributes to human health and scientific evidences for the effects of WCGs on modulating Gut microbiota.
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Colonic inflammation accompanies an increase of β-catenin signaling and Lachnospiraceae/Streptococcaceae bacteria in the hind gut of high-fat diet-fed mice.
TL;DR: In this article, the authors showed that long-term high-fat (HF) feeding accelerates inflammatory process and changes gut microbiome composition, which is associated with dramatic increases in body fat composition, inflammatory cell infiltration, inducible nitric oxide synthase protein concentration and cell proliferation marker (Ki67) in ileum and colon.
Journal ArticleDOI
Cinnamaldehyde supplementation prevents fasting‐induced hyperphagia, lipid accumulation, and inflammation in high‐fat diet‐fed mice
Pragyanshu Khare,Sneha Jagtap,Yachna Jain,Ritesh K. Baboota,Priyanka Mangal,Ravneet K. Boparai,Kamlesh K. Bhutani,Shyam S. Sharma,Louis S. Premkumar,Kanthi Kiran Kondepudi,Kanwaljit Chopra,Mahendra Bishnoi +11 more
TL;DR: Cinnamaldehyde increased adipose tissue lipolysis, decreased fasting-induced hyperphagia, normalized circulating levels of leptin/ghrelin ratio, and reduced inflammation in HFD-fed mice, which augurs well for its antiobesity role.
References
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Millet consumption decreased serum concentration of triglyceride and C-reactive protein but not oxidative status in hyperlipidemic rats
TL;DR: FM and proso millet may prevent cardiovascular disease by reducing plasma triglycerides in hyperlipidemic rats; in contrast, sorghum increases total cholesterol, HDL-ch cholesterol, and LDL-cholesterol concentrations.
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Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype.
Takashi Sawada,Hideaki Miyoshi,Kohei Shimada,Akira Suzuki,Yuko Okamatsu-Ogura,James W. Perfield,Takuma Kondo,So Nagai,Chikara Shimizu,Narihito Yoshioka,Andrew S. Greenberg,Kazuhiro Kimura,Takao Koike +12 more
TL;DR: These findings demonstrate that overexpression of PeriA in white adipocytes reduces lipid droplet size by decreasing FSP27 expression and thereby inducing a brown adipose tissue-like phenotype, and suggest that modulation of lipid droplets proteins inwhite adipocytes is a potential therapeutic strategy for the treatment of obesity and its related disorders.
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The effect of finger millet feeding on the early responses during the process of wound healing in diabetic rats.
TL;DR: FM feeding to the diabetic animals, for 4 weeks, controlled the glucose levels and improved the antioxidant status, which hastened the dermal wound healing process, which played a vital role in delaying wound healing in diabetic rats.
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Resistant starch from differently processed rice and ragi (finger millet)
TL;DR: In this paper, resistant starch (RS) formed during parboiling, expanding, popping, flaking, roller drying, extrusion cooking, malting and autoclaving of rice and ragi was determined.
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