Gender differences in the association of visceral and subcutaneous adiposity with adiponectin in African Americans: the Jackson Heart Study
Aurelian Bidulescu,Jiankang Liu,DeMarc A. Hickson,DeMarc A. Hickson,Kristen G. Hairston,Ervin R. Fox,Donna K. Arnett,Anne E. Sumner,Herman A. Taylor,Herman A. Taylor,Gary H. Gibbons +10 more
TLDR
The statistically significant inverse association of VAT and adiponectin persisted after additionally adjusting for SAT, body mass index (BMI) and waist circumference (WC), suggesting that VAT provides significant information above and beyond BMI and WC.Abstract:
Adiponectin, paradoxically reduced in obesity and with lower levels in African Americans (AA), modulates several cardiometabolic risk factors. Because abdominal visceral adipose tissue (VAT), known to be reduced in AA, and subcutaneous adipose tissue (SAT) compartments may confer differential metabolic risk profiles, we investigated the associations of VAT and SAT with serum adiponectin, separately by gender, with the hypothesis that VAT is more strongly inversely associated with adiponectin than SAT. Participants from the Jackson Heart Study, an ongoing cohort of AA (n = 2,799; 64% women; mean age, 55 ± 11 years) underwent computer tomography assessment of SAT and VAT volumes, and had stored serum specimens analyzed for adiponectin levels. These levels were examined by gender in relation to increments of VAT and SAT. Compared to women, men had significantly lower mean levels of adiponectin (3.9 ± 3.0 μg/mL vs. 6.0 ± 4.4 μg/mL; p < 0.01) and mean volume of SAT (1,721 ± 803 cm3 vs. 2,668 ± 968 cm3; p < 0.01) but significantly higher mean volume of VAT (884 ± 416 cm3 vs. 801 ± 363 cm3; p < 0.01). Among women, a one standard deviation increment in VAT was inversely associated with adiponectin (β = − 0.13; p < 0.0001) after controlling for age, systolic blood pressure, fasting plasma glucose, high-density lipoprotein cholesterol, triglycerides, education, pack-years of smoking and daily intake of alcohol. The statistically significant inverse association of VAT and adiponectin persisted after additionally adjusting for SAT, body mass index (BMI) and waist circumference (WC), suggesting that VAT provides significant information above and beyond BMI and WC. Among men, after the same multivariable adjustment, there was a direct association of SAT and adiponectin (β = 0.18; p = 0.002) that persisted when controlling for BMI and WC, supporting a beneficial effect of SAT. Insulin resistance mediated the association of SAT with adiponectin in women. In African Americans, abdominal visceral adipose tissue had an inverse association with serum adiponectin concentrations only among women. Abdominal subcutaneous adipose tissue appeared as a protective fat depot in men.read more
Citations
More filters
Journal ArticleDOI
Serum adiponectin is associated with body composition and cognitive and psychological status in older adults living in long-term nursing homes.
Begoña Sanz,Haritz Arrieta,Gotzone Hervás,Chloe Rezola-Pardo,Fátima Ruiz-Litago,Miren Iturburu,Susana María Gil,Ana Rodriguez-Larrad,Jon Irazusta +8 more
TL;DR: The results of this study show that adiponectin is linked to body composition, cognitive function and anxiety in long‐term nursing home residents with differential relationships by sex.
Journal ArticleDOI
Smoking is associated with more abdominal fat in morbidly obese patients.
Raquel Chatkin,José Miguel Chatkin,Lucas Spanemberg,Daniela Schaan Casagrande,Mario Bernardes Wagner,Cláudio Corá Mottin +5 more
TL;DR: It is speculated that the findings may indicate that the coexistence of morbid obesity and smoking helps to explain the more serious medical conditions, particularly cardiovascular diseases and neoplasms, seen in these patients.
Journal ArticleDOI
Sex differences in regional adipose tissue depots pose different threats for the development of Type 2 diabetes in males and females
Kerri Z. Delaney,Sylvia Santosa +1 more
TL;DR: It is shown that the origins of T2DM development differ between males and females, and the ability of female adipose tissue to expand all regions through hyperplasia, rather than hypertrophy, protects them against the development of large insulin‐resistant adipocytes that dominate male adiposes tissue.
Journal ArticleDOI
Associations of adiponectin with individual European ancestry in African Americans: the Jackson Heart Study.
Aurelian Bidulescu,Shweta Choudhry,Solomon K. Musani,Sarah G. Buxbaum,Jiankang Liu,Charles N. Rotimi,James G. Wilson,Herman A. Taylor,Gary H. Gibbons +8 more
TL;DR: In a large AA population, the individual proportion of European ancestry was linearly and directly associated with plasma adiponectin among non-obese and non insulin-resistant participants, pointing to the interaction of genetic and metabolic factors influencing adip onectin levels.
Journal ArticleDOI
Visceral and subcutaneous abdominal adiposity and pulmonary function in 30-year-old adults: a cross-sectional analysis nested in a birth cohort
Paula Duarte de Oliveira,Fernando C. Wehrmeister,Bernardo L. Horta,Rogelio Pérez-Padilla,Giovanny Vinícius Araújo de França,Denise Petrucci Gigante,Fernando C. Barros,Ken K. Ong,Emanuella De Lucia Rolfe,Ana M. B. Menezes +9 more
TL;DR: VAT has a consistent inverse association with FEV1 and FVC in both sexes and SAT showed inconsistent results with PF parameters, in both crude and adjusted models.
References
More filters
Journal ArticleDOI
Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
TL;DR: The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Journal ArticleDOI
Positional cloning of the mouse obese gene and its human homologue
Yiying Zhang,Ricardo Proenca,Ricardo Proenca,Margherita Maffei,Marisa Barone,Marisa Barone,Lori Leopold,Lori Leopold,Jeffrey M. Friedman,Jeffrey M. Friedman +9 more
TL;DR: The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.
Journal ArticleDOI
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Journal ArticleDOI
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
Yukio Arita,Shinji Kihara,Noriyuki Ouchi,Masahiko Takahashi,Kazuhisa Maeda,Jun-ichiro Miyagawa,Kikuko Hotta,Iichiro Shimomura,Tadashi Nakamura,Koji Miyaoka,Hiroshi Kuriyama,Makoto Nishida,Shizuya Yamashita,Kosaku Okubo,Kenji Matsubara,Masahiro Muraguchi,Yasuichi Ohmoto,Tohru Funahashi,Yuji Matsuzawa +18 more
TL;DR: Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue.
Journal ArticleDOI
The hormone resistin links obesity to diabetes
Claire M. Steppan,Shannon T. Bailey,Savitha Bhat,Elizabeth J. Brown,Ronadip R. Banerjee,Christopher M. Wright,Hiralben R. Patel,Rexford S. Ahima,Mitchell A. Lazar +8 more
TL;DR: It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.