Gene-environment interactions for complex traits: Definitions, methodological requirements and challenges
Astrid Dempfle,André Scherag,André Scherag,Rebecca Hein,Lars Beckmann,Jenny Chang-Claude,Helmut Schäfer +6 more
TLDR
This review discusses methodological issues involved in investigating gene–environment (G × E) interactions in genetic–epidemiological studies of complex diseases and their potential relevance for clinical application and attempts to clarify conceptual differences of the term ‘interaction’ in the statistical and biological sciences.Abstract:
Genetic and environmental risk factors and their interactions contribute to the development of complex diseases In this review, we discuss methodological issues involved in investigating gene-environment (G x E) interactions in genetic-epidemiological studies of complex diseases and their potential relevance for clinical application Although there are some important examples of interactions and applications, the widespread use of the knowledge about G x E interaction for targeted intervention or personalized treatment (pharmacogenetics) is still beyond current means This is due to the fact that convincing evidence and high predictive or discriminative power are necessary conditions for usefulness in clinical practice We attempt to clarify conceptual differences of the term 'interaction' in the statistical and biological sciences, since precise definitions are important for the interpretation of results We argue that the investigation of G x E interactions is more rewarding for the detailed characterization of identified disease genes (ie at advanced stages of genetic research) and the stratified analysis of environmental effects by genotype or vice versa Advantages and disadvantages of different epidemiological study designs are given and sample size requirements are exemplified These issues as well as a critical appraisal of common methodological concerns are finally discussedread more
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Interaction between lifestyle behaviors and genetic polymorphism in SCAP gene on blood pressure among Chinese children.
Yide Yang,Yide Yang,Jie-Yun Song,Shuo Wang,Yang Wang,Qi-Ying Song,Chen-Xiong Li,Bin Dong,Hai-Jun Wang,Jun Ma +9 more
TL;DR: Interactions or combined effects between SCAP and lifestyle behaviors on BP support the importance of promoting a healthy lifestyle in the children genetically predisposed to higher BP.
Journal ArticleDOI
Interactions between breast cancer susceptibility loci and menopausal hormone therapy in relationship to breast cancer in the Breast and Prostate Cancer Cohort Consortium
Mia M. Gaudet,Myrto Barrdahl,Sara Lindström,Ruth C. Travis,Paul L. Auer,Paul L. Auer,Julie E. Buring,Stephen J. Chanock,A. Heather Eliassen,Susan M. Gapstur,Graham G. Giles,Graham G. Giles,Graham G. Giles,Marc J. Gunter,Christopher A. Haiman,David J. Hunter,Amit Joshi,Rudolf Kaaks,Kay-Tee Khaw,I. Min Lee,Loic Le Marchand,Roger L. Milne,Roger L. Milne,Petra H.M. Peeters,Petra H.M. Peeters,Malin Sund,Rulla M. Tamimi,Antonia Trichopoulou,Elisabete Weiderpass,Xiaohong R. Yang,Ross L. Prentice,Ross L. Prentice,Heather Spencer Feigelson,Federico Canzian,Peter Kraft +34 more
TL;DR: Menopausal hormone therapy is unlikely to have a strong interaction with the common genetic variants associated with invasive breast cancer, and observed associations might be modified by known breast cancer susceptibility loci.
Journal ArticleDOI
Integrating Multi–Omics Data for Gene-Environment Interactions
Yinhao Du,Kun Fan,Xi Lu,Cen Wu +3 more
TL;DR: The integrative model can efficiently pinpoint important regulators of gene expressions through sparse dimensionality reduction, and link the disease outcomes to multiple effects in the integrative G×E studies through accommodating a sparse bi-level structure.
Dissertation
Genomic architecture of sickle cell disease clinical variation in children from West Africa : a case-control study design
TL;DR: Genome-wide gene expression patterns associated with SCD clinical variation were enriched in B-lymphocyte development, platelet activation, stress, inflammation and cell proliferation pathways and Transcriptional biomarkers that can discriminate SCD patients with respect to clinical severities were identified.
Journal ArticleDOI
Advancing the science of environmental exposures during pregnancy and the gene-environment through the National Children's Study.
TL;DR: Information is provided on the importance of studying environmental exposures during fetal, infant, and childhood development in the National Children's Study for nurses to aid in mitigating the complex health problems that arise from environment-health interactions.
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