Genome-wide computational prediction of miRNAs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) revealed target genes involved in pulmonary vasculature and antiviral innate immunity.
Sandeep Saini,Avneet Saini,Chander Jyoti Thakur,Varinder Kumar,Rishabh Dilip Gupta,Jogesh Kumar Sharma +5 more
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TLDR
Gen enrichment tool analysis and substantial literature evidences suggests role of genes like BMPR2 and p53 in pulmonary vasculature and antiviral innate immunity respectively and predicted 26 mature miRNAs from genome of SARS-CoV-2 that targets human genes involved in pathways like EGF receptors signaling, apoptosis signaling, VEGF signaling, FGF receptor signaling.Abstract:
The current outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China threatened humankind worldwide. The coronaviruses contains the largest RNA genome among all other known RNA viruses, therefore the disease etiology can be understood by analyzing the genome sequence of SARS-CoV-2. In this study, we used an ab-intio based computational tool VMir to scan the complete genome of SARS-CoV-2 to predict pre-miRNAs. The potential pre-miRNAs were identified by ViralMir and mature miRNAs were recognized by Mature Bayes. Additionally, predicted mature miRNAs were analysed against human genome by miRDB server to retrieve target genes. Besides that we also retrieved GO (Gene Ontology) terms for pathways, functions and cellular components. We predicted 26 mature miRNAs from genome of SARS-CoV-2 that targets human genes involved in pathways like EGF receptor signaling, apoptosis signaling, VEGF signaling, FGF receptor signaling. Gene enrichment tool analysis and substantial literature evidences suggests role of genes like BMPR2 and p53 in pulmonary vasculature and antiviral innate immunity respectively. Our findings may help research community to understand virus pathogenesis.read more
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MicroRNAs and SARS-CoV-2 life cycle, pathogenesis, and mutations: biomarkers or therapeutic agents?
Farshad Abedi,Ramin Rezaee,A. Wallace Hayes,A. Wallace Hayes,Somayyeh Nasiripour,Gholamreza Karimi +5 more
TL;DR: In this paper, the role of microRNAs in the pathophysiology of coronavirus disease 2019 (COVID-19) patients has been investigated and several promising miRNAs as a biomarker or antiviral agent in COVID-2019 therapy are reviewed.
Journal ArticleDOI
The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review.
Rafael D. Marchi,Bruna M. Sugita,Ariana Centa,Aline S. Fonseca,Stefanne Bortoletto,Karine Fiorentin,Solange G. da Silva Ferreira,Luciane R. Cavalli +7 more
TL;DR: The role, function, and/or association of miRNAs in SARS-CoV-2 human infection and COVID-19 has been investigated in this paper, where the role and function of microRNAs is not completely known.
Journal ArticleDOI
Multilevel systems biology analysis of lung transcriptomics data identifies key miRNAs and potential miRNA target genes for SARS-CoV-2 infection.
Babajan Banaganapalli,Nuha Alrayes,Zuhier Awan,Faten A. S. Alsulaimany,Abdulhakeem S. Alamri,Ramu Elango,Zubbair Malik,Noor Ahmad Shaik +7 more
TL;DR: In this article, a multilevel robust computational analysis was undertaken for viral genetic sequence alignment, phylogram construction, genome-wide transcriptome data interpretation of virus-infected lung tissues, miRNA mapping, and functional biology networking.
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SnoRNAs and miRNAs Networks Underlying COVID-19 Disease Severity.
Aijaz Parray,Fayaz Mir,Asmma Doudin,Ahmad Iskandarani,Ibn Mohammed Masud Danjuma,Ibn Mohammed Masud Danjuma,Rahim Ayadathil Thazhhe Kuni,Alaaedin A. Abdelmajid,Ibrahim Abdelhafez,Ibrahim Abdelhafez,Rida Arif,Mohammad Mulhim,Mohammad Abukhattab,Shoukat Rashhid Dar,Ala-Eddin Al Moustafa,Eyad Elkord,Eyad Elkord,Abdul Latif Al Khal,Abdel-Naser Elzouki,Abdel-Naser Elzouki,Farhan S. Cyprian +20 more
TL;DR: In this article, the authors identify microRNAs (miRNAs)/small nucleolar RNAs (snoRNAs) as potential biomarkers of COVID-19 severity.
Journal ArticleDOI
MiRNA-SARS-CoV-2 dialogue and prospective anti-COVID-19 therapies
TL;DR: In this paper , the authors report the critical miRNA molecule and their regular expression in patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and associated comorbidities.
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