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Book ChapterDOI

Genomics and Traditional Indian Ayurvedic Medicine

TLDR
Ayurgenomics is proposed as a novel approach for integration of Ayurveda into current medical practice to address the variability in therapeutic outcome as well as evolve preventive measures in health and disease.
Abstract
In the present times need is being felt for a change in paradigm from the current practice of modern medicine. This is not only to meet the challenges in diagnosis and treatment of chronic and complex diseases but also to address the variability in therapeutic outcome as well as evolve preventive measures in health and disease. The advent of genomics has provided a tremendous impetus to this area. However, there are a number of gaps before this is realized. Ayurveda, the ancient Indian system of predictive and personalized medicine still holds contemporary in the current era of P4 (predictive, preventive, personalized, and participatory) medicine and also has a promotive component. Ayurveda has documented methods for maintenance of health and personalized management of diseases. It is also widely practiced in most Indian communities despite sociocultural variations and many aspects for preventive health are also integrated into Indian traditional living. Despite this a large number of challenges exist in getting this system to mainstream and for its global acceptability. This review highlights some of these aspects and also proposes Ayurgenomics as a novel approach for integration of Ayurveda into current medical practice.

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Journal Article

Interactome networks and human disease

TL;DR: Why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease are detailed.
Journal ArticleDOI

Ayurgenomics and Modern Medicine.

TL;DR: The development of Ayurgenomics could greatly enrich P4 medicine by providing a clear theoretical understanding of the whole patient and a practical application of ancient and modern preventative and therapeutic practices to improve mental and physical health.
Book Chapter

Ethnopharmacology and drug discovery

TL;DR: The list of compounds derived from such knowledge is very long indeed and includes morphine, codeine, and aspirin to name just a few but also drugs licensed relatively recently like galanthamine and artemisinine as mentioned in this paper.
References
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Journal ArticleDOI

Diet rapidly and reproducibly alters the human gut microbiome

TL;DR: Increases in the abundance and activity of Bilophila wadsworthia on the animal-based diet support a link between dietary fat, bile acids and the outgrowth of microorganisms capable of triggering inflammatory bowel disease.
Journal Article

Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower, +247 more
- 01 Jun 2012 - 
TL;DR: The Human Microbiome Project has analysed the largest cohort and set of distinct, clinically relevant body habitats so far, finding the diversity and abundance of each habitat’s signature microbes to vary widely even among healthy subjects, with strong niche specialization both within and among individuals.
Journal ArticleDOI

The DNA-damage response in human biology and disease

TL;DR: The authors' improving understanding of DNA-damage responses is providing new avenues for disease management, and these responses are biologically significant because they prevent diverse human diseases.
Journal ArticleDOI

The large-scale organization of metabolic networks

TL;DR: In this paper, the authors present a systematic comparative mathematical analysis of the metabolic networks of 43 organisms representing all three domains of life, and show that despite significant variation in their individual constituents and pathways, these metabolic networks have the same topological scaling properties and show striking similarities to the inherent organization of complex non-biological systems.
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