Glioblastoma targeted therapy: updated approaches from recent biological insights
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TLDR
The most promising biological insights that have opened the way for the development of targeted therapies in glioblastoma are reviewed, and recent data from clinical trials evaluating targeted therapies and immunotherapies are examined.About:
This article is published in Annals of Oncology.The article was published on 2017-07-01 and is currently open access. It has received 304 citations till now. The article focuses on the topics: Targeted therapy & Precision medicine.read more
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Journal ArticleDOI
Targeted Therapies for Brain Tumors: Will They Ever Deliver?
TL;DR: The neuro-oncology community is beginning to recognize that phase 0 studies should be performed to account for the impact of the blood–brain barrier on the ability of a therapeutic to reach its target(s).
Journal ArticleDOI
The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells.
Jolie Bou-Gharios,Sahar Assi,Hisham F. Bahmad,Hisham F. Bahmad,Hussein Kharroubi,Tarek Araji,Reda M. Chalhoub,Reda M. Chalhoub,Farah Ballout,Hayat Harati,Youssef Fares,Wassim Abou-Kheir +11 more
TL;DR: TDG has proven its effectiveness in targeting the cancerous properties of GBM in vitro and may, hence, serve as a potential adjuvant radio-therapeutic agent to better target this deadly tumor.
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Diagnostic Yield and Complication Rate of Stereotactic Biopsies in Precision Medicine of Gliomas
Sophie Katzendobler,Anna T. Do,Jonathan Weller,Mario M. Dorostkar,Nathalie L. Albert,Robert Forbrig,Maximilian Niyazi,Rupert Egensperger,Niklas Thon,Jörg C. Tonn,S. Quach +10 more
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Targeting BCL-2 as a Therapeutic Strategy for Primary p210BCR-ABL1-positive B-ALL Cells.
Michele Massimino,Elena Tirrò,Stefania Stella,Maria Stella Pennisi,Silvia Rita Vitale,Adriana Puma,Chiara Romano,Sandra Di Gregorio,Maria Anna Romeo,Francesco Di Raimondo,Livia Manzella +10 more
TL;DR: BCL-2 is a key survival factor for primary Ph+ B-ALL cells and its inhibition - alone or in combination with a BCR-ABL1 TKI - should be further investigated as a potential therapeutic strategy for these patients.
Journal ArticleDOI
Using genomics to guide treatment for glioblastoma.
TL;DR: As technology continues to improve, exome and RNA sequencing will play a role in the design of clinical trials, classification of patient subgroups and identification of rare mutations that can be targeted by small-molecule inhibitors and biologic agents.
References
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Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Roger Stupp,Warren P. Mason,Martin J. van den Bent,Michael Weller,Barbara Fisher,Martin J.B. Taphoorn,Karl Belanger,Alba A. Brandes,Christine Marosi,Ulrich Bogdahn,Jürgen Curschmann,Robert C. Janzer,Samuel K. Ludwin,Thierry Gorlia,Anouk Allgeier,Denis Lacombe,J. Gregory Cairncross,Elizabeth Eisenhauer,René O. Mirimanoff +18 more
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TL;DR: The interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated gliobeasts, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.
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