Glioblastoma targeted therapy: updated approaches from recent biological insights
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TLDR
The most promising biological insights that have opened the way for the development of targeted therapies in glioblastoma are reviewed, and recent data from clinical trials evaluating targeted therapies and immunotherapies are examined.About:
This article is published in Annals of Oncology.The article was published on 2017-07-01 and is currently open access. It has received 304 citations till now. The article focuses on the topics: Targeted therapy & Precision medicine.read more
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A Potential New Treatment for High-Grade Glioma: A Study Assessing Repurposed Drug Combinations against Patient-Derived High-Grade Glioma Cells
TL;DR: It is demonstrated that the local delivery of drug combinations has the potential to be more effective than temozolomide, while slowing down or eradicating tumour recurrence, as a novel treatment strategy for high-grade gliomas.
Journal ArticleDOI
In Silico Analysis of miRNA-mediated ceRNAs as Potential Molecular Biomarkers in Glioblastoma
TL;DR: It is determined that NRXN3 acts as a tumor suppressor gene and NRxN3 gene is downregulated in glioblastoma, and PBX3 gene functions as an oncogene and is upregulated in GBM.
Journal ArticleDOI
Identification of ubiquitin-specific protease 32 as an oncogene in glioblastoma and the underlying mechanisms
Sifang Chen,Xi Chen,Zhangyu Li,Jianyao Mao,Wei Jiang,Zhi Zhu,Yukui Li,Zhengye Jiang,Wenpeng Zhao,Guowei Tan,Zhanxiang Wang +10 more
TL;DR: In this paper , the role of USP32 in GBM progression and potential target for GBM treatment was evaluated using Gene Expression Omnibus databases and RT-qPCR was used to validate divergent expression of genes involved in the enriched pathways.
Journal ArticleDOI
A Tumor-Homing Peptide Platform Enhances Drug Solubility, Improves Blood–Brain Barrier Permeability and Targets Glioblastoma
Choi-Fong Cho,Charlotte E. Farquhar,Colin M. Fadzen,Benjamin Scott,Pei Zhuang,Niklas von Spreckelsen,Andrei Loas,Nina Hartrampf,Bradley L. Pentelute,Sean E. Lawler +9 more
TL;DR: It is demonstrated that conjugation of BTP-7 to CPT improves drug solubility in aqueous solution, retains drug efficacy against patient-derived GBM stem cells (GSC), enhances BBB permeability, and enables therapeutic targeting to intracranial GBM, leading to higher toxicity in GBM cells compared to normal brain tissues, and ultimately prolongs survival in mice bearing intrac Cranial patient- derived GBM xenograft.
References
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Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Roger Stupp,Warren P. Mason,Martin J. van den Bent,Michael Weller,Barbara Fisher,Martin J.B. Taphoorn,Karl Belanger,Alba A. Brandes,Christine Marosi,Ulrich Bogdahn,Jürgen Curschmann,Robert C. Janzer,Samuel K. Ludwin,Thierry Gorlia,Anouk Allgeier,Denis Lacombe,J. Gregory Cairncross,Elizabeth Eisenhauer,René O. Mirimanoff +18 more
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TL;DR: The interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated gliobeasts, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.
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