Global cancer statistics
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TLDR
A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.Abstract:
The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors, particularly smoking, in economically developing countries. Based on the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Lung cancer is the leading cancer site in males, comprising 17% of the total new cancer cases and 23% of the total cancer deaths. Breast cancer is now also the leading cause of cancer death among females in economically developing countries, a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Further, the mortality burden for lung cancer among females in developing countries is as high as the burden for cervical cancer, with each accounting for 11% of the total female cancer deaths. Although overall cancer incidence rates in the developing world are half those seen in the developed world in both sexes, the overall cancer mortality rates are generally similar. Cancer survival tends to be poorer in developing countries, most likely because of a combination of a late stage at diagnosis and limited access to timely and standard treatment. A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination (for liver and cervical cancers), and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake. Clinicians, public health professionals, and policy makers can play an active role in accelerating the application of such interventions globally.read more
Citations
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Yttrium-90 microspheres for the treatment of hepatocellular carcinoma.
Jean Francois H. Geschwind,Riad Salem,Brian I. Carr,Michael C. Soulen,Kenneth G. Thurston,Kathleen Goin,Mark Van Buskirk,Carol A. Roberts,James E. Goin +8 more
TL;DR: In selected patients with hepatocellular carcinoma, yttrium-90 microsphere treatment is safe and well tolerated, and on the basis of these results, a randomized controlled trial is warranted compared with transarterial chemoembolization by using the Cancer of the Liver Italian Program system for prospective stratified randomization.
Journal ArticleDOI
LncRNA profile study reveals a three-lncRNA signature associated with the survival of patients with oesophageal squamous cell carcinoma
Jiagen Li,Zhaoli Chen,Liqing Tian,Chengcheng Zhou,Max Yifan He,Yibo Gao,Suya Wang,Fang Zhou,Susheng Shi,Xiaoli Feng,Nan Sun,Ziyuan Liu,Geir Skogerboe,Jingsi Dong,Ran Yao,Yuda Zhao,Jian Sun,Baihua Zhang,Yue Yu,Xuejiao Shi,Mei Luo,Kang Shao,Ning Li,Bin Qiu,Fengwei Tan,Runsheng Chen,Jie He +26 more
TL;DR: The results suggest that the three-lncRNA signature is a new biomarker for the prognosis of patients with OSCC, enabling more accurate prediction of survival.
Journal ArticleDOI
Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation.
TL;DR: An important role of activation-induced cytidine deaminase, a nucleotide-editing enzyme essential for somatic hypermutation and class-switch recombination of the immunoglobulin gene, as a genomic modulator in inflammation-associated cancer development is highlighted.
Journal ArticleDOI
Pathology of Gastric Intestinal Metaplasia: Clinical Implications
TL;DR: The aims of this article are to assist the clinician in identifying subgroups of patients with IM at increased risk for gastric cancer and to propose an algorithm for Gastric IM management, considering the lack of universally accepted guidelines that can be applied to any population.
Journal Article
Discovery of New Markers of Cancer through Serial Analysis of Gene Expression Prostate Stem Cell Antigen Is Overexpressed in Pancreatic Adenocarcinoma
Pedram Argani,Christophe Rosty,Robert E. Reiter,Robb E. Wilentz,Selva R. Murugesan,Steven D. Leach,Byungwoo Ryu,Halcyon G. Skinner,Michael Goggins,Elizabeth M. Jaffee,Charles J. Yeo,John L. Cameron,Scott E. Kern,Ralph H. Hruban +13 more
TL;DR: PSCA is a novel tumor marker for pancreatic carcinoma that has potential diagnostic and therapeutic implications and establishes the validity of analyses of SAGE databases to identify novel tumor markers.
References
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Screening and Prostate-Cancer Mortality in a Randomized European Study
Fritz H. Schröder,Jonas Hugosson,Monique J. Roobol,Stefano Ciatto,Vera Nelen,Maciej Kwiatkowski,Marcos Lujan,Hans Lilja,Marco Zappa,Louis Denis,Franz Recker,A. Berenguer,Liisa Määttänen,Chris H. Bangma,Gunnar Aus,Arnauld Villers,Xavier Rebillard,Theodorus van der Kwast,Bert G. Blijenberg,Sue Moss,Harry J. de Koning,Anssi Auvinen +21 more
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