Global cancer statistics
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TLDR
A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.Abstract:
The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors, particularly smoking, in economically developing countries. Based on the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Lung cancer is the leading cancer site in males, comprising 17% of the total new cancer cases and 23% of the total cancer deaths. Breast cancer is now also the leading cause of cancer death among females in economically developing countries, a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Further, the mortality burden for lung cancer among females in developing countries is as high as the burden for cervical cancer, with each accounting for 11% of the total female cancer deaths. Although overall cancer incidence rates in the developing world are half those seen in the developed world in both sexes, the overall cancer mortality rates are generally similar. Cancer survival tends to be poorer in developing countries, most likely because of a combination of a late stage at diagnosis and limited access to timely and standard treatment. A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination (for liver and cervical cancers), and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake. Clinicians, public health professionals, and policy makers can play an active role in accelerating the application of such interventions globally.read more
Citations
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Journal ArticleDOI
Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels - "ABC method".
TL;DR: The current status of screening for gastric cancer-risk using combined assay for serum anti-Helicobacter pylori (Hp) IgG antibody and serum pepsinogen (PG) levels, “ABC method”, was reviewed and the latest results of the ongoing trial are reported.
Journal ArticleDOI
Understanding the Biological Basis of Autofluorescence Imaging for Oral Cancer Detection: High-Resolution Fluorescence Microscopy in Viable Tissue
Ina Pavlova,Michelle D. Williams,Adel K. El-Naggar,Rebecca Richards-Kortum,Ann M. Gillenwater +4 more
TL;DR: Imaging oral lesions with optical devices/probes that sample mostly stromal fluorescence may result in a similar loss of fluorescence intensity and may fail to distinguish benign from precancerous lesions.
Journal ArticleDOI
STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation
Hazel Tye,Catherine Kennedy,Meri Najdovska,Louise McLeod,William McCormack,Norman R. Hughes,Anouk Dev,William Sievert,Chia Huey Ooi,Tomo-o Ishikawa,Hiroko Oshima,Prithi S. Bhathal,Andrew E. Parker,Masanobu Oshima,Patrick Tan,Patrick Tan,Brendan J. Jenkins +16 more
TL;DR: An unexpected role for TLR2 in the oncogenic function of STAT3 that may represent a therapeutic target in GC is revealed.
Journal ArticleDOI
Gastritis OLGA-staging and gastric cancer risk: a twelve-year clinico-pathological follow-up study.
Massimo Rugge,M. De Boni,Gianmaria Pennelli,M. De Bona,Luciano Giacomelli,Matteo Fassan,Daniela Basso,Mario Plebani,D. P. Graham +8 more
TL;DR: In this article, the gastritis OLGA-staging (Operative Link for Gastritis Assessment) was used in prognosticating neoplastic progression in colorectal cancer patients.
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Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression
TL;DR: Findings suggest that lncRNA MEG3, a ceRNA of miR-181 s, could regulate gastric carcinogenesis and may serve as a potential target for antineoplastic therapies.
References
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