Global cancer statistics
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TLDR
A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.Abstract:
The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors, particularly smoking, in economically developing countries. Based on the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Lung cancer is the leading cancer site in males, comprising 17% of the total new cancer cases and 23% of the total cancer deaths. Breast cancer is now also the leading cause of cancer death among females in economically developing countries, a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Further, the mortality burden for lung cancer among females in developing countries is as high as the burden for cervical cancer, with each accounting for 11% of the total female cancer deaths. Although overall cancer incidence rates in the developing world are half those seen in the developed world in both sexes, the overall cancer mortality rates are generally similar. Cancer survival tends to be poorer in developing countries, most likely because of a combination of a late stage at diagnosis and limited access to timely and standard treatment. A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination (for liver and cervical cancers), and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake. Clinicians, public health professionals, and policy makers can play an active role in accelerating the application of such interventions globally.read more
Citations
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Journal ArticleDOI
Pathobiology of Helicobacter pylori-induced Gastric Cancer
Manuel R. Amieva,Richard M. Peek +1 more
TL;DR: The realization that external environmental factors, such as dietary components and essential micronutrients, as well as the gastrointestinal microbiota, can change the balance between H pylori's activity as a commensal or a pathogen has provided direction to studies aimed at defining the full carcinogenic potential of this organism.
Journal ArticleDOI
Protection From Right- and Left-Sided Colorectal Neoplasms After Colonoscopy: Population-Based Study
Hermann Brenner,Michael Hoffmeister,Volker Arndt,Christa Stegmaier,Lutz Altenhofen,Ulrike Haug +5 more
TL;DR: Prevalence of left- sided advanced colorectal neoplasms, but not right-sided advanced neoplasm, was strongly reduced within a 10-year period after colonoscopy, even in the community setting.
Journal ArticleDOI
National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers
Catharine M. Sturgeon,Michael J. Duffy,Ulf-Håkan Stenman,Hans Lilja,Nils Brünner,Daniel W. Chan,Richard J. Babaian,Robert C. Bast,Barry L. Dowell,Francisco J. Esteva,Caj Haglund,Nadia Harbeck,Daniel F. Hayes,Mads Nikolaj Holten-Andersen,George G. Klee,Rolf Lamerz,Leendert H. J. Looijenga,Rafael Molina,Hans Jørgen Nielsen,Harry G. Rittenhouse,Axel Semjonow,Ie Ming Shih,Paul Sibley,György Sölétormos,Carsten Stephan,Lori J. Sokoll,Barry Hoffman,Eleftherios P. Diamandis +27 more
TL;DR: Recommendations to encourage optimal use of tumor markers for 5 cancer sites were critically reviewed and alpha-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase are recommended for diagnosis/case finding, staging, prognosis determination, recurrence detection, and therapy monitoring.
Journal ArticleDOI
Neoadjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysis
TL;DR: Although platinum based combination chemotherapy was beneficial, there was no evidence to support the use of single-agent platinum, and there was a significant difference in the effect between these groups of trials.
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The 630-kb Lung Cancer Homozygous Deletion Region on Human Chromosome 3p21.3: Identification and Evaluation of the Resident Candidate Tumor Suppressor Genes
Michael I. Lerman,John D. Minna +1 more
TL;DR: A approximately 630-kb lung cancer homozygous deletion region harboring one or more tumor suppressor genes (TSGs) on chromosome 3p21 is defined and several of the genes in the region are excluded as classical tumor suppressors for sporadic lung cancer.
References
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Screening and Prostate-Cancer Mortality in a Randomized European Study
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