Global cancer statistics
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TLDR
A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.Abstract:
The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors, particularly smoking, in economically developing countries. Based on the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Lung cancer is the leading cancer site in males, comprising 17% of the total new cancer cases and 23% of the total cancer deaths. Breast cancer is now also the leading cause of cancer death among females in economically developing countries, a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Further, the mortality burden for lung cancer among females in developing countries is as high as the burden for cervical cancer, with each accounting for 11% of the total female cancer deaths. Although overall cancer incidence rates in the developing world are half those seen in the developed world in both sexes, the overall cancer mortality rates are generally similar. Cancer survival tends to be poorer in developing countries, most likely because of a combination of a late stage at diagnosis and limited access to timely and standard treatment. A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination (for liver and cervical cancers), and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake. Clinicians, public health professionals, and policy makers can play an active role in accelerating the application of such interventions globally.read more
Citations
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Field-practice study of sorafenib therapy for hepatocellular carcinoma: a prospective multicenter study in Italy.
Massimo Iavarone,Giuseppe Cabibbo,Fabio Piscaglia,Claudio Zavaglia,Antonio Grieco,Erica Villa,Calogero Cammà,Massimo Colombo +7 more
TL;DR: Overall, safety, effectiveness, and generalizability of sorafenib therapy in HCC was validated in field practice and the effectiveness of half‐dosed sorafinib may have implications for tailored therapy.
Journal ArticleDOI
A serum circulating miRNA diagnostic test to identify asymptomatic high‐risk individuals with early stage lung cancer
Fabrizio Bianchi,Francesco Nicassio,Matteo Jacopo Marzi,Elena Belloni,Valentina Dall'Olio,Loris Bernard,Giuseppe Pelosi,Patrick Maisonneuve,Giulia Veronesi,Pier Paolo Di Fiore,Pier Paolo Di Fiore +10 more
TL;DR: A test, based on the detection of 34 microRNAs (miRNAs) from serum, that could identify patients with early stage non‐small cell lung carcinomas (NSCLCs) in a population of asymptomatic high‐risk individuals with 80% accuracy is developed.
Journal ArticleDOI
A Systematic Review and Meta-analysis of the Randomized Controlled Trials on Adjuvant Intraperitoneal Chemotherapy for Resectable Gastric Cancer
Tristan D. Yan,Tristan D. Yan,Deborah Black,Paul H. Sugarbaker,J. C. Zhu,Yutaka Yonemura,George Petrou,David L. Morris +7 more
TL;DR: The present meta-analysis indicates that HIIC with or without EPIC after resection of advanced gastric primary cancer is associated with improved overall survival, but increased risk of intra-abdominal abscess and neutropenia are also demonstrated.
Journal ArticleDOI
Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240)
Krishnansu S. Tewari,Michael W. Sill,Richard T. Penson,Helen Huang,Lois M. Ramondetta,Lisa M. Landrum,Ana Oaknin,Thomas J. Reid,Thomas J. Reid,Mario M. Leitao,Helen Michael,Philip J. DiSaia,Larry J. Copeland,William T. Creasman,Frederick B. Stehman,Mark F. Brady,Robert A. Burger,J. Tate Thigpen,Michael J. Birrer,Steven E Waggoner,David H. Moore,Katherine Y. Look,Wui Jin Koh,Bradley J. Monk +23 more
TL;DR: In this article, the authors report the prespecified final analysis of the primary objectives, OS and adverse events, assessed at the second interim and final analysis by the masked Data and Safety Monitoring Board.
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Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma
Vinod Kumar,Naoya Kato,Yuji Urabe,Atsushi Takahashi,Ryosuke Muroyama,Naoya Hosono,Motoyuki Otsuka,Ryosuke Tateishi,Masao Omata,Hidewaki Nakagawa,Kazuhiko Koike,Naoyuki Kamatani,Michiaki Kubo,Yusuke Nakamura,Koichi Matsuda +14 more
TL;DR: A previously unidentified locus in the 5′ flanking region of MICA on 6p21.33 was found to be strongly associated with HCV-induced HCC and the risk allele of rs2596542 was associated with lower soluble MICA protein levels in individuals withHCV- induced HCC.
References
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