Global cancer statistics
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TLDR
A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.Abstract:
The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors, particularly smoking, in economically developing countries. Based on the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Lung cancer is the leading cancer site in males, comprising 17% of the total new cancer cases and 23% of the total cancer deaths. Breast cancer is now also the leading cause of cancer death among females in economically developing countries, a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Further, the mortality burden for lung cancer among females in developing countries is as high as the burden for cervical cancer, with each accounting for 11% of the total female cancer deaths. Although overall cancer incidence rates in the developing world are half those seen in the developed world in both sexes, the overall cancer mortality rates are generally similar. Cancer survival tends to be poorer in developing countries, most likely because of a combination of a late stage at diagnosis and limited access to timely and standard treatment. A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination (for liver and cervical cancers), and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake. Clinicians, public health professionals, and policy makers can play an active role in accelerating the application of such interventions globally.read more
Citations
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The mutation spectrum revealed by paired genome sequences from a lung cancer patient
William Lee,Zhaoshi Jiang,Jinfeng Liu,Peter M. Haverty,Yinghui Guan,Jeremy Stinson,Peng Yue,Yan Zhang,Krishna P. Pant,Deepali Bhatt,Connie Ha,Stephanie Johnson,Michael I. Kennemer,Sankar Mohan,Igor Nazarenko,Colin K. Watanabe,Andrew B. Sparks,David S. Shames,Robert Gentleman,Frederic J. de Sauvage,Howard M. Stern,Ajay Pandita,Dennis G. Ballinger,Radoje Drmanac,Zora Modrusan,Somasekar Seshagiri,Zemin Zhang +26 more
TL;DR: A comprehensive view of somatic alterations in a single lung tumour is presented, and the first evidence, to the authors' knowledge, of distinct selective pressures present within the tumour environment is provided.
Journal ArticleDOI
The transcriptional landscape and mutational profile of lung adenocarcinoma
Jeong-Sun Seo,Young Seok Ju,Won-Chul Lee,Jong Yeon Shin,June Koo Lee,Thomas Bleazard,Junho Lee,Yoo Jin Jung,Jung Oh Kim,Jung Young Shin,Saet Byeol Yu,Jihye Kim,Eung Ryoung Lee,Chang Hyun Kang,In Kyu Park,Hwanseok Rhee,Se-Hoon Lee,Jong Il Kim,Jin Hyoung Kang,Young Tae Kim,Young Tae Kim,Young Tae Kim +21 more
TL;DR: The first large scale RNA sequencing study of lung adenocarcinoma is presented, demonstrating its power to identify somatic point mutations as well as transcriptional variants such as gene fusions, alternative splicing events, and expression outliers.
Journal ArticleDOI
Mediastinoscopy vs Endosonography for Mediastinal Nodal Staging of Lung Cancer: A Randomized Trial
Jouke T. Annema,Jan P. van Meerbeeck,Robert C. Rintoul,Christophe Dooms,Ellen Deschepper,Olaf M. Dekkers,Paul De Leyn,Jerry Braun,Nicholas Carroll,Marleen Praet,Frederick de Ryck,Johan Vansteenkiste,Frank Vermassen,Michel I.M. Versteegh,Maud Veselic,Andrew G. Nicholson,Klaus F. Rabe,Kurt G. Tournoy +17 more
TL;DR: Among patients with (suspected) NSCLC, a staging strategy combining endosonography and surgical staging compared with surgical staging alone resulted in greater sensitivity for mediastinal nodal metastases and fewer unnecessary thoracotomies.
Journal ArticleDOI
Worldwide burden of colorectal cancer: a review.
Pasqualino Favoriti,Gabriele Carbone,Marco Greco,Felice Pirozzi,Raffaele Pirozzi,Francesco Corcione +5 more
TL;DR: The aim of this paper is to provide a review of incidence, mortality and survival rates for colorectal cancer as well as their geographic variations and temporal trends.
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Genomics and signaling pathways in hepatocellular carcinoma.
TL;DR: A review summarizes the most relevant information regarding structural and functional alterations in HCC and describes some of the key signaling pathways implicated in hepatocarcinogenesis.
References
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Screening and Prostate-Cancer Mortality in a Randomized European Study
Fritz H. Schröder,Jonas Hugosson,Monique J. Roobol,Stefano Ciatto,Vera Nelen,Maciej Kwiatkowski,Marcos Lujan,Hans Lilja,Marco Zappa,Louis Denis,Franz Recker,A. Berenguer,Liisa Määttänen,Chris H. Bangma,Gunnar Aus,Arnauld Villers,Xavier Rebillard,Theodorus van der Kwast,Bert G. Blijenberg,Sue Moss,Harry J. de Koning,Anssi Auvinen +21 more
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