Global cancer statistics
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TLDR
A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.Abstract:
The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors, particularly smoking, in economically developing countries. Based on the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Lung cancer is the leading cancer site in males, comprising 17% of the total new cancer cases and 23% of the total cancer deaths. Breast cancer is now also the leading cause of cancer death among females in economically developing countries, a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Further, the mortality burden for lung cancer among females in developing countries is as high as the burden for cervical cancer, with each accounting for 11% of the total female cancer deaths. Although overall cancer incidence rates in the developing world are half those seen in the developed world in both sexes, the overall cancer mortality rates are generally similar. Cancer survival tends to be poorer in developing countries, most likely because of a combination of a late stage at diagnosis and limited access to timely and standard treatment. A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination (for liver and cervical cancers), and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake. Clinicians, public health professionals, and policy makers can play an active role in accelerating the application of such interventions globally.read more
Citations
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Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics
Majid Ebrahimi Warkiani,Majid Ebrahimi Warkiani,Bee Luan Khoo,Bee Luan Khoo,Lidan Wu,Andy Tay,Andy Tay,Ali Asgar S. Bhagat,Jongyoon Han,Jongyoon Han,Chwee Teck Lim,Chwee Teck Lim +11 more
TL;DR: This protocol describes detailed procedures for the production and use of a label-free spiral microfluidic device to allow size-based isolation of viable CTCs using hydrodynamic forces that are present in curvilinear microchannels.
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The Human Gut Microbiome as a Screening Tool for Colorectal Cancer
TL;DR: The results of this study demonstrate the feasibility of using the composition of the gut microbiome to detect the presence of precancerous and cancerous lesions and support the need for more cross-sectional studies with diverse populations and linkage to other stool markers, dietary data, and personal health information.
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The role of m6A RNA methylation in cancer.
Ting Sun,Ruiyan Wu,Liang Ming +2 more
TL;DR: This review focuses on m6A-associated mechanisms and functions in several major malignancies and summarizes the dual role of m 6A methylation as well as its prospects in cancer.
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Predicting the future burden of cancer.
Freddie Bray,Bjørn Møller +1 more
TL;DR: This work explains how and why cancer predictions are made, with examples to illustrate the concepts in practice, and explains the forces that drive time trends.
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Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer.
Wing Pui Tsang,Enders K.O. Ng,Simon S.M. Ng,Hongchuan Jin,Jun Yu,Joseph J.Y. Sung,Tim Tak Kwok +6 more
TL;DR: It is demonstrated that H19-derived miR-675, through downregulation of its target RB, regulates the CRC development and thus may serve as a potential target for CRC therapy.
References
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Screening and Prostate-Cancer Mortality in a Randomized European Study
Fritz H. Schröder,Jonas Hugosson,Monique J. Roobol,Stefano Ciatto,Vera Nelen,Maciej Kwiatkowski,Marcos Lujan,Hans Lilja,Marco Zappa,Louis Denis,Franz Recker,A. Berenguer,Liisa Määttänen,Chris H. Bangma,Gunnar Aus,Arnauld Villers,Xavier Rebillard,Theodorus van der Kwast,Bert G. Blijenberg,Sue Moss,Harry J. de Koning,Anssi Auvinen +21 more
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