Global cancer statistics
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TLDR
A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.Abstract:
The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors, particularly smoking, in economically developing countries. Based on the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Lung cancer is the leading cancer site in males, comprising 17% of the total new cancer cases and 23% of the total cancer deaths. Breast cancer is now also the leading cause of cancer death among females in economically developing countries, a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Further, the mortality burden for lung cancer among females in developing countries is as high as the burden for cervical cancer, with each accounting for 11% of the total female cancer deaths. Although overall cancer incidence rates in the developing world are half those seen in the developed world in both sexes, the overall cancer mortality rates are generally similar. Cancer survival tends to be poorer in developing countries, most likely because of a combination of a late stage at diagnosis and limited access to timely and standard treatment. A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination (for liver and cervical cancers), and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake. Clinicians, public health professionals, and policy makers can play an active role in accelerating the application of such interventions globally.read more
Citations
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Journal Article
Comparison of self-collected vaginal, vulvar and urine samples with physician-collected cervical samples for human papillomavirus testing to detect high-grade squamous intraepithelial lesions
John W. Sellors,Attila T. Lorincz,James B. Mahony,Iwona Mielzynska,Alice Lytwyn,Paula Roth,Michelle Howard,Sylvia Chong,Dean Daya,William Chapman,Max Chernesky +10 more
TL;DR: Self-collection of samples for HPV testing was acceptable to women attending a colposcopy clinic for investigation of suspected cervical lesions and shows sufficient sensitivity to warrant further evaluation as a screening test for cervical cancer prevention programs.
Journal ArticleDOI
Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines.
TL;DR: The present observations indicate that stem cell patterns are robust and persist even in cell lines, and an understanding of this behavior should facilitate studies directed towards the molecular or pharmacologic manipulation of malignant stem cell survival.
Journal ArticleDOI
The Long Noncoding RNA HOTAIR Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma Cells via downregualtion of p21WAF1/CIP1 Expression
Zhi-Li Liu,Ming Sun,Kaihua Lu,Jing Liu,Meiling Zhang,Wei-qin Wu,Wei De,Zhaoxia Wang,Rui Wang +8 more
TL;DR: It is suggested that upregulation of HOTAIR contributes to the cisplatin resistance of LAD cells, at least in part, through the regulation of p21 expression.
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AXL Mediates Resistance to PI3Kα Inhibition by Activating the EGFR/PKC/mTOR Axis in Head and Neck and Esophageal Squamous Cell Carcinomas
Moshe Elkabets,Evangelos Pazarentzos,Dejan Juric,Qing Sheng,Raphael Pelossof,Samuel Brook,Ana Oaknin Benzaken,Jordi Rodon,Natasha Morse,Jenny Jiacheng Yan,Manway Liu,Rita Das,Yan Chen,Angela Tam,Hui-Qin Wang,Jinsheng Liang,Joseph M. Gurski,Darcy A. Kerr,Rafael Rosell,Cristina Teixidó,Alan Huang,Ronald Ghossein,Neal Rosen,Trever G. Bivona,Maurizio Scaltriti,José Baselga +25 more
TL;DR: It is observed that SCC cells that become refractory to PI3Kα inhibition maintainPI3K-independent activation of the mammalian target of rapamycin (mTOR), which is mediated by the tyrosine kinase receptor AXL.
Journal ArticleDOI
Results of the Randomized Danish Lung Cancer Screening Trial with Focus on High-Risk Profiling
Mathilde M. W. Wille,Asger Dirksen,Haseem Ashraf,Zaigham Saghir,Karen S. Bach,John Brodersen,Paul Frost Clementsen,Hanne Foss Hansen,Klaus Richter Larsen,Jann Mortensen,Jakob Fraes Rasmussen,Niels Seersholm,Birgit Guldhammer Skov,Laura H. Thomsen,Philip Tønnesen,Jesper Holst Pedersen +15 more
TL;DR: Older participants, those with chronic obstructive pulmonary disease, and those with more than 35 pack-years of smoking had a significantly increased risk of death due to lung cancer, with nonsignificantly fewer deaths in the screening group.
References
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Journal ArticleDOI
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Screening and Prostate-Cancer Mortality in a Randomized European Study
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