Global cancer statistics
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TLDR
A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.Abstract:
The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors, particularly smoking, in economically developing countries. Based on the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Lung cancer is the leading cancer site in males, comprising 17% of the total new cancer cases and 23% of the total cancer deaths. Breast cancer is now also the leading cause of cancer death among females in economically developing countries, a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Further, the mortality burden for lung cancer among females in developing countries is as high as the burden for cervical cancer, with each accounting for 11% of the total female cancer deaths. Although overall cancer incidence rates in the developing world are half those seen in the developed world in both sexes, the overall cancer mortality rates are generally similar. Cancer survival tends to be poorer in developing countries, most likely because of a combination of a late stage at diagnosis and limited access to timely and standard treatment. A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination (for liver and cervical cancers), and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake. Clinicians, public health professionals, and policy makers can play an active role in accelerating the application of such interventions globally.read more
Citations
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Effects of microrna-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma
TL;DR: An important role is highlighted in the regulation of apoptosis and in the molecular etiology of HCC, and the potential application of miR‐29 in prognosis prediction and in cancer therapy is implicate.
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Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: two meta-analyses of individual patient data.
Rodrigo Arriagada,A. Auperin,S Burdett,Julian P T Higgins,David H. Johnson,T. Le Chevalier,C. Le Pechoux,M K B Parmar,J.P. Pignon,Robert L. Souhami,Richard Stephens,Lesley A. Stewart,Jayne F. Tierney,Hélène Tribodet,J. Van Meerbeeck +14 more
TL;DR: The addition of adjuvant chemotherapy after surgery for patients with operable non-small-cell lung cancer improves survival, irrespective of whether chemotherapy was adjuant to surgery alone or to surgery plus radiotherapy.
Journal ArticleDOI
DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice
Lisiane B. Meira,James M. Bugni,Stephanie L. Green,Chung-Wei Lee,Bo Pang,Diana Borenshtein,Barry H. Rickman,Arlin B. Rogers,Catherine A. Moroski-Erkul,Jose L. McFaline,David B. Schauer,Peter C. Dedon,James G. Fox,Leona D. Samson +13 more
TL;DR: It is shown that Aag-mediated DNA repair prevents colonic epithelial damage and reduces the severity of dextran sulfate sodium-induced colon tumorigenesis and is demonstrated that the repair of DNA lesions formed by RONS during chronic inflammation is important for protection against colon carcinogenesis.
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Mert Erkan,Simone Hausmann,Christoph W. Michalski,Alexander A. Fingerle,Martin Dobritz,Jörg Kleeff,Helmut Friess +6 more
TL;DR: Targeting the tumour stroma, in combination with chemotherapy, is a promising new option for the treatment of PDAC.
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BRAF V600E and TERT Promoter Mutations Cooperatively Identify the Most Aggressive Papillary Thyroid Cancer With Highest Recurrence
Mingzhao Xing,Rengyun Liu,Xiaoli Liu,Avaniyapuram Kannan Murugan,Guangwu Zhu,Martha A. Zeiger,Sara I. Pai,Justin A. Bishop +7 more
TL;DR: Coexisting BRAF V600E and TERT C228T mutations form a novel genetic background that defines PTC with the worst clinicopathologic outcomes, providing unique prognostic and therapeutic implications.
References
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