Journal ArticleDOI
Growth stimulation and induction of epidermal growth factor receptor by overexpression of cyclooxygenases 1 and 2 in human colon carcinoma cells.
Takahiro Kinoshita,Yoshitaka Takahashi,Toshiki Sakashita,Hiroyasu Inoue,Tadashi Tanabe,Tanihiro Yoshimoto +5 more
Reads0
Chats0
TLDR
No differences in growth stimulation were observed between the COX-1 andCOX-2 overexpressions in the authors' experiments, and subtle differences between the both cell lines would be possibly apparent by lower expression levels.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1999-04-19. It has received 97 citations till now. The article focuses on the topics: A431 cells & Growth factor receptor inhibitor.read more
Citations
More filters
Journal ArticleDOI
Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.
Rama Pai,Brian A. Soreghan,Brian A. Soreghan,Imre Szabó,Imre Szabó,Meredith Pavelka,Meredith Pavelka,Dolgor Baatar,Dolgor Baatar,Andrzej S. Tarnawski,Andrzej S. Tarnawski +10 more
TL;DR: Evidence is provided that prostaglandin E2 (PGE2) rapidly phosphorylates EGFR and triggers the extracellular signal-regulated kinase 2 (ERK2)–mitogenic signaling pathway in normal gastric epithelial and colon cancer cell lines, revealing a previously unknown mechanism by which PGE2 mediates trophic actions resulting in gastric and intestinal hypertrophy as well as growth of colonic polyps and cancers.
Journal ArticleDOI
Combinatorial chemoprevention of intestinal neoplasia.
Christopher J. Torrance,Peta E. Jackson,Peta E. Jackson,Elizabeth A. Montgomery,Kenneth W. Kinzler,Bert Vogelstein,Allan Wissner,Maria Tereza Nunes,Philip Frost,Carolyn Discafani +9 more
TL;DR: A combination of two drugs afforded remarkable protection from intestinal neoplasia in APCMin/+ mice, a murine model of human familial adenomatous polyposis, suggesting a powerful strategy for the chemoprevention of human colonic neopl Asia.
Journal ArticleDOI
Biochemistry of Cyclooxygenase (COX)-2 Inhibitors and Molecular Pathology of COX-2 in Neoplasia
TL;DR: Findings might somewhat limit the use of presently available selective COX-2 inhibitors in cancer prevention but will probably not deter their successful application for the treatment of human cancers.
Journal ArticleDOI
EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus.
Mitsuhiko Hanawa,Shioto Suzuki,Yoh Dobashi,Tetsu Yamane,Koji Kono,Nobuyuki Enomoto,Akishi Ooi,Akishi Ooi +7 more
TL;DR: In conclusion, anti‐EGFR therapies may be appropriate for patients with ESCC and combined analyses by immunohistochemistry/FISH would clarify aberrations in protein and gene function, and could help to identify those patients who may benefit from anti-EGFR therapy.
Journal ArticleDOI
T Cell–Inflamed versus Non-T Cell–Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection
TL;DR: To maximize the impact of immunotherapy drug development, pretreatment stratification of targets associated with either the T cell–inflated or noninflamed tumor microenvironment should be employed and biomarkers predictive of responsiveness to specific immunomodulatory therapies should guide therapy selection.
References
More filters
Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
Journal ArticleDOI
Signal transduction by receptors with tyrosine kinase activity
Axel Ullrich,Joseph Schlessinger +1 more
TL;DR: Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction and notamment jouent le role de signal de the transduction.
Journal ArticleDOI
Cyclooxygenases 1 and 2
TL;DR: The discovery ofCOX-2 has made possible the design of drugs that reduce inflammation without removing the protective PGs in the stomach and kidney made by COX-1, which may not only be anti-inflammatory but may also be active in colon cancer and Alzheimer's disease.
Journal ArticleDOI
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
Axel Ullrich,Lisa M. Coussens,Joel S. Hayflick,Thomas J. Dull,Alane M. Gray,A W Tam,Jeffrey E. Lee,Yosef Yarden,Towia A. Libermann,Joseph Schlessinger +9 more
TL;DR: The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains.