Guidelines on management of low-grade gliomas: report of an EFNS–EANO* Task Force
Riccardo Soffietti,Brigitta G. Baumert,Lorenzo Bello,A. von Deimling,Hugues Duffau,Marc Frenay,Wolfgang Grisold,Robin Grant,Francesc Graus,Khê Hoang-Xuan,Martin Klein,Beatrice Melin,Jeremy Rees,Tali Siegal,Anja Smits,Roger Stupp,Wolfgang Wick +16 more
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TLDR
Diffuse infiltrative low‐grade gliomas of the cerebral hemispheres in the adult are a group of tumors with distinct clinical, histological and molecular characteristics, and there are still controversies in management.Abstract:
Background: Diffuse infiltrative low-grade gliomas of the cerebral hemispheres in the adult are a group of tumors with distinct clinical, histological and molecular characteristics, and there are still controversies in management.
Methods: The scientific evidence of papers collected from the literature was evaluated and graded according to EFNS guidelines, and recommendations were given accordingly.
Results and conclusions: WHO classification recognizes grade II astrocytomas, oligodendrogliomas and oligoastrocytomas. Conventional MRI is used for differential diagnosis, guiding surgery, planning radiotherapy and monitoring treatment response. Advanced imaging techniques can increase the diagnostic accuracy. Younger age, normal neurological examination, oligodendroglial histology and 1p loss are favorable prognostic factors. Prophylactic antiepileptic drugs are not useful, whilst there is no evidence that one drug is better than the others. Total/near total resection can improve seizure control, progression-free and overall survival, whilst reducing the risk of malignant transformation. Early post-operative radiotherapy improves progression-free but not overall survival. Low doses of radiation are as effective as high doses and better tolerated. Modern radiotherapy techniques reduce the risk of late cognitive deficits. Chemotherapy can be useful both at recurrence after radiotherapy and as initial treatment after surgery to delay the risk of late neurotoxicity from large-field radiotherapy. Neurocognitive deficits are frequent and can be caused by the tumor itself, tumor-related epilepsy, treatments and psychological distress.read more
Citations
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European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas
Michael Weller,Martin J. van den Bent,Jörg C. Tonn,Roger Stupp,Matthias Preusser,Elizabeth Cohen-Jonathan-Moyal,Roger Henriksson,Emilie Le Rhun,Carmen Balana,Olivier Chinot,Martin Bendszus,Jaap C. Reijneveld,F. Dhermain,Pim J. French,Christine Marosi,Colin Watts,Ingela Oberg,Geoffrey J. Pilkington,Brigitta G. Baumert,Martin J.B. Taphoorn,Monika E. Hegi,Manfred Westphal,Guido Reifenberger,Riccardo Soffietti,Wolfgang Wick,Wolfgang Wick +25 more
TL;DR: The European Association for Neuro-Oncology guideline provides recommendations for the clinical care of adult patients with astrocytic and oligodendroglial gliomas, including glioblastomas, based on the 2016 WHO classification of tumours of the central nervous system and on scientific developments since the 2014 guideline.
Journal ArticleDOI
EANO guidelines for the diagnosis and treatment of meningiomas
Roland Goldbrunner,Giuseppe Minniti,Matthias Preusser,Michael D. Jenkinson,Kita Sallabanda,Emmanuel Houdart,Andreas von Deimling,Pantelis Stavrinou,Florence Lefranc,Morten Lund-Johansen,Elizabeth Cohen-Jonathan Moyal,Dieta Brandsma,Roger Henriksson,Riccardo Soffietti,Michael Weller +14 more
TL;DR: The meningioma task force of the European Association of Neuro-Oncology (EANO) assessed the scientific literature and composed a framework of the best possible evidence-based recommendations for health professionals.
Journal ArticleDOI
Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome in trials of diffuse low-grade gliomas
M. J. van den Bent,Jeffrey S. Wefel,David Schiff,Martin J.B. Taphoorn,Kurt A. Jaeckle,Larry Junck,Terri Armstrong,Terri Armstrong,A. Choucair,Adam D. Waldman,Thierry Gorlia,Marc C. Chamberlain,Brigitta G. Baumert,Michael A. Vogelbaum,David R. Macdonald,David A. Reardon,Patrick Y. Wen,Susan M. Chang,Andreas H. Jacobs +18 more
TL;DR: Clinical and imaging endpoints in trials of low-grade gliomas are investigated, response assessment in neuro-oncology (RANO) criteria for non-enhancing tumours is provided, and other measures for patients with brain tumours that assess outcome are described.
Journal ArticleDOI
CGCG clinical practice guidelines for the management of adult diffuse gliomas
Tao Jiang,Do-Hyun Nam,Zvi Ram,Wai Sang Poon,Jiguang Wang,Damdindorj Boldbaatar,Ying Mao,Wenbin Ma,Qing Mao,Yongping You,Chuanlu Jiang,Xuejun Yang,Chunsheng Kang,Xiaoguang Qiu,Wenbin Li,Shaowu Li,Ling Chen,Xuejun Li,Zhixiong Liu,Weimin Wang,Hongmin Bai,Yu Yao,Shouwei Li,Anhua Wu,Ke Sai,Guilin Li,Kun Yao,Xinting Wei,Xianzhi Liu,Zhiwen Zhang,Yiwu Dai,Sheng-Qing Lv,Liang Wang,Zhixiong Lin,Jun Dong,Guozheng Xu,Xiaodong Ma,Wei Zhang,Chuanbao Zhang,Baoshi Chen,Gan You,Yongzhi Wang,Yinyan Wang,Zhaoshi Bao,Pei Yang,Xing Fan,Xing Liu,Zheng Zhao,Zheng Wang,Yiming Li,Zhiliang Wang,Guanzhang Li,Shengyu Fang,Lianwang Li,Yanwei Liu,Shuai Liu,Xia Shan,Yu-Qing Liu,Ruichao Chai,Huimin Hu,Jing Chen,Wei Yan,Jinquan Cai,Hongjun Wang,Lingchao Chen,Yuan Yang,Yu Wang,Lei Han,Qixue Wang +68 more
TL;DR: The recommendations will provide a framework and assurance for the strategy of diagnostic and therapeutic measures to reduce complications from unnecessary treatment and cost and should serve as an application for all professionals involved in the management of patients with adult diffuse glioma and also as a source of knowledge for insurance companies and other institutionsinvolved in the cost regulation of cancer care in China.
Journal ArticleDOI
Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases: clinical article.
Laurent Capelle,Denys Fontaine,Emmanuel Mandonnet,Luc Taillandier,Jean Louis Golmard,Luc Bauchet,Johan Pallud,Philippe Peruzzi,Marie Hélène Baron,Michèle Kujas,Jacques Guyotat,Remi Guillevin,Marc Frenay,Sophie Taillibert,Philippe Colin,Valérie Rigau,F. Vandenbos,Catherine Pinelli,Hugues Duffau,French Réseau d'Étude des Gliomes +19 more
TL;DR: This large series with its volumetric assessment refines the prognostic value of previously stressed clinical and radiological parameters and highlights the importance of tumor size and location.
References
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The 2007 WHO Classification of Tumours of the Central Nervous System
David N. Louis,Hiroko Ohgaki,Otmar D. Wiestler,Webster K. Cavenee,Peter C. Burger,Anne Jouvet,Bernd W. Scheithauer,Paul Kleihues +7 more
TL;DR: The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneurs tumour of the fourth ventricle, Papillary tumourof the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis.
Journal ArticleDOI
Role of Extent of Resection in the Long-Term Outcome of Low-Grade Hemispheric Gliomas
Justin S. Smith,Edward F. Chang,Kathleen R. Lamborn,Susan M. Chang,Michael D. Prados,Soonmee Cha,Tarik Tihan,Scott R. VandenBerg,Michael W. McDermott,Mitchel S. Berger +9 more
TL;DR: Improved outcome among adult patients with hemispheric LGG is predicted by greater EOR, and progression-free survival was predicted by log preoperative tumor volume and postoperative volume.
Journal Article
Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging
Meng Law,Stanley Yang,Hao Wang,James S. Babb,James S. Babb,Glyn Johnson,Soonmee Cha,Edmond A. Knopp,David Zagzag +8 more
TL;DR: The rCBV measurements had the most superior diagnostic performance (either with or without metabolite ratios) in predicting glioma grade and can be used in a clinical setting to evaluate tumors preoperatively for histologic grade and provide a means for guiding treatment and predicting postoperative patient outcome.
Journal ArticleDOI
Analysis of the IDH1 codon 132 mutation in brain tumors
Jörg Balss,Jochen Meyer,Wolf Mueller,Andrey Korshunov,Andrey Korshunov,Christian Hartmann,Christian Hartmann,Andreas von Deimling,Andreas von Deimling +8 more
TL;DR: The very high frequency of IDH1 mutations in WHO grade II astrocytic and oligodendroglial gliomas suggests a role in early tumor development.
Journal ArticleDOI
Isocitrate Dehydrogenase 1 Codon 132 Mutation Is an Important Prognostic Biomarker in Gliomas
Marc Sanson,Yannick Marie,Sophie Paris,Ahmed Idbaih,Julien Laffaire,François Ducray,Soufiane El Hallani,Blandine Boisselier,Karima Mokhtari,Khê Hoang-Xuan,Jean-Yves Delattre +10 more
TL;DR: This study indicates that IDH1 codon 132 mutation is closely linked to the genomic profile of the tumor and constitutes an important prognostic marker in grade 2 to 4 gliomas.