Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages.
Sang Heon Suh,Kibaek Choe,Seon Pyo Hong,Seung-hwan Jeong,Taija Makinen,Kwang Soon Kim,Kari Alitalo,Charles D Surh,Gou Young Koh,Joo Hye Song +9 more
TLDR
It is concluded that the gut microbiota is a crucial regulator for lacteal integrity by endowing its unique microenvironment and regulating villus macrophages in small intestine.Abstract:
A lacteal is a blunt-ended, long, tube-like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine. However, key regulators for maintaining lacteal integrity are poorly understood. Here, we explore whether and how the gut microbiota regulates lacteal integrity. Germ depletion by antibiotic treatment triggers lacteal regression during adulthood and delays lacteal maturation during the postnatal period. In accordance with compromised lipid absorption, the button-like junction between lymphatic endothelial cells, which is ultrastructurally open to permit free entry of dietary lipids into lacteals, is significantly reduced in lacteals of germ-depleted mice. Lacteal defects are also found in germ-free mice, but conventionalization of germ-free mice leads to normalization of lacteals. Mechanistically, VEGF-C secreted from villus macrophages upon MyD88-dependent recognition of microbes and their products is a main factor in lacteal integrity. Collectively, we conclude that the gut microbiota is a crucial regulator for lacteal integrity by endowing its unique microenvironment and regulating villus macrophages in small intestine.read more
Citations
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Comprehensive review of targeted therapy for colorectal cancer
TL;DR: This review provides an overview of existing CRC-targeted agents and their underlying mechanisms, as well as a discussion of their limitations and future trends.
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Biological functions of lymphatic vessels
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TL;DR: This Review provides an overview of the recent advances in the understanding of new functions of adult mammalian lymphatic vessels, such as immunomodulation, contribution to neurodegenerative and neuroinflammatory diseases, and response to anticancer therapies.
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Mechanisms Ensuring Endothelial Junction Integrity Beyond VE-Cadherin
TL;DR: Which other adhesive mechanisms contribute to the stability and regulation of endothelial junctions and cooperate with VE-cadherin in intact vessels are discussed and endothelial receptors will be discussed.
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Gut mycobiomes are altered in people with type 2 Diabetes Mellitus and Diabetic Retinopathy.
Rajagopalaboopathi Jayasudha,Taraprasad Das,Sama Kalyana Chakravarthy,Gumpili Sai Prashanthi,Archana Bhargava,Mudit Tyagi,Padmaja Kumari Rani,Rajeev R Pappuru,Sisinthy Shivaji +8 more
TL;DR: Dysbiosis in the gut mycobiomes in people with T2DM and DR compared to HC was demonstrated and differences were significant both at the phyla and genera level between people withT2 DM and DR as well.
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Lymphatic Endothelial Cell Junctions: Molecular Regulation in Physiology and Diseases.
TL;DR: Understanding lymphatic junction remodeling is important in order to unravel lymphatic drainage regulation in obesity and inflammatory diseases and may pave the way towards future novel therapeutic interventions.
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