Hypoxia-associated induction of early growth response-1 gene expression.
Shi Fang Yan,Jiesheng Lu,Yu Shan Zou,Jae Soh-Won,David M. Cohen,Peter M. Buttrick,Denise R. Cooper,Susan F. Steinberg,Nigel Mackman,David J. Pinsky,David M. Stern +10 more
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TLDR
It is proposed that activation of Egr-1 in response to hypoxia induces a different facet of the adaptive response than HIF-1, one component of which causes expression of tissue factor, resulting in fibrin deposition.About:
This article is published in Journal of Biological Chemistry.The article was published on 1999-05-21 and is currently open access. It has received 246 citations till now. The article focuses on the topics: Serum response factor & Serum Response Element.read more
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Hypoxia — a key regulatory factor in tumour growth
TL;DR: Cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signalling pathways that regulate proliferation, angiogenesis and death, and many elements of the hypoxia-response pathway are good candidates for therapeutic targeting.
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'Pseudopalisading' necrosis in glioblastoma: A familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis
TL;DR: Vaso-occlusive and prothrombotic mechanisms in GBM could readily explain the presence of pseudopalisading necrosis in tissue sections, the rapid peripheral expansion on neuroimaging, and the dramatic shift to an accelerated rate of clinical progression resulting from hypoxia-induced angiogenesis.
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Hypoxia, gene expression, and metastasis
Denise A. Chan,Amato J. Giaccia +1 more
TL;DR: Clinical and basic science studies that support an important role for hypoxia in increasing the metastatic potential of tumor cells by promoting tissue remodeling, inducing angiogenesis and reducing apoptosis are discussed.
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Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress
Shi Fang Yan,Tomoyuki Fujita,Jiesheng Lu,Kenji Okada,Yu Shan Zou,Nigel Mackman,David J. Pinsky,David M. Stern +7 more
TL;DR: A central and unifying role is defined for Egr-1 activation in the pathogenesis of ischemic tissue damage as a master switch activated by ischemia to trigger expression of pivotal regulators of inflammation, coagulation and vascular hyperpermeability.
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Hypoxia-responsive transcription factors
Eoin P. Cummins,Cormac T. Taylor +1 more
TL;DR: This review comprehensively discusses the transcription factors that have been reported to be hypoxia-responsive and the signalling mechanisms leading to their activation and aims to enhance the understanding of cellular oxygen sensing.
References
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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
TL;DR: A procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters, including tRNA and Ad 2 VA, is developed.
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A synthetic inhibitor of the mitogen-activated protein kinase cascade.
TL;DR: Results indicate that the MAPK pathway is essential for growth and maintenance of the ras-transformed phenotype and PD 098059 is an invaluable tool that will help elucidate the role of theMAPK cascade in a variety of biological settings.
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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
Narayan V. Iyer,Lori E. Kotch,Faton Agani,Sandra W. Leung,Erik Laughner,Roland H. Wenger,Max Gassmann,John D. Gearhart,Ann M. Lawler,Aimee Y. Yu,Gregg L. Semenza +10 more
TL;DR: It is demonstrated that HIF-1alpha is a master regulator of cellular and developmental O2 homeostasis in Hif1a-/- embryos that manifested neural tube defects, cardiovascular malformations, and marked cell death within the cephalic mesenchyme.
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Improved technique utilizing nonfat dry milk for analysis of proteins and nucleic acids transferred to nitrocellulose
TL;DR: The incubation cocktail, termed BLOTTO (Bovine Lacto Transfer Technique Optimizer), is superior to bovine serum albumin or gelatin for preventing nonspecific absorption in Western blot analyses and does not require the use of detergents or chaotropic agents to effect efficient reduction of background.
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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.
TL;DR: The essential role of HIF‐1α in controlling both embryonic and tumorigenic responses to variations in microenvironmental oxygenation is demonstrated.
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Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors.
Andrea Gashler,Vikas P. Sukhatme +1 more