Journal ArticleDOI
ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs – Threshold Doses for Tissue Reactions in a Radiation Protection Context
F A Stewart,A V Akleyev,Martin Hauer-Jensen,Jolyon H Hendry,N J Kleiman,Thomas J. MacVittie,B M Aleman,Angela B. Edgar,K Mabuchi,C R Muirhead,Roy E. Shore,William Wallace +11 more
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Estimates of ‘practical’ threshold doses for tissue injury defined at the level of 1% incidence are provided and it appears that the rate of dose delivery does not modify the low incidence for reactions manifesting very late after low total doses, particularly for cataracts and circulatory disease.Abstract:
This report provides a review of early and late effects of radiation in normal tissues and organs with respect to radiation protection. It was instigated following a recommendation in Publication 103 (ICRP, 2007), and it provides updated estimates of 'practical' threshold doses for tissue injury defined at the level of 1% incidence. Estimates are given for morbidity and mortality endpoints in all organ systems following acute, fractionated, or chronic exposure. The organ systems comprise the haematopoietic, immune, reproductive, circulatory, respiratory, musculoskeletal, endocrine, and nervous systems; the digestive and urinary tracts; the skin; and the eye. Particular attention is paid to circulatory disease and cataracts because of recent evidence of higher incidences of injury than expected after lower doses; hence, threshold doses appear to be lower than previously considered. This is largely because of the increasing incidences with increasing times after exposure. In the context of protection, it is the threshold doses for very long follow-up times that are the most relevant for workers and the public; for example, the atomic bomb survivors with 40-50years of follow-up. Radiotherapy data generally apply for shorter follow-up times because of competing causes of death in cancer patients, and hence the risks of radiation-induced circulatory disease at those earlier times are lower. A variety of biological response modifiers have been used to help reduce late reactions in many tissues. These include antioxidants, radical scavengers, inhibitors of apoptosis, anti-inflammatory drugs, angiotensin-converting enzyme inhibitors, growth factors, and cytokines. In many cases, these give dose modification factors of 1.1-1.2, and in a few cases 1.5-2, indicating the potential for increasing threshold doses in known exposure cases. In contrast, there are agents that enhance radiation responses, notably other cytotoxic agents such as antimetabolites, alkylating agents, anti-angiogenic drugs, and antibiotics, as well as genetic and comorbidity factors. Most tissues show a sparing effect of dose fractionation, so that total doses for a given endpoint are higher if the dose is fractionated rather than when given as a single dose. However, for reactions manifesting very late after low total doses, particularly for cataracts and circulatory disease, it appears that the rate of dose delivery does not modify the low incidence. This implies that the injury in these cases and at these low dose levels is caused by single-hit irreparable-type events. For these two tissues, a threshold dose of 0.5Gy is proposed herein for practical purposes, irrespective of the rate of dose delivery, and future studies may elucidate this judgement further.read more
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Multiphase CT Angiography: A New Tool for the Imaging Triage of Patients with Acute Ischemic Stroke
Bijoy K Menon,Christopher D d'Esterre,Emmad Qazi,Mohammed A. Almekhlafi,Leszek Hahn,Andrew M. Demchuk,Mayank Goyal +6 more
TL;DR: Multiphase CT angiography is a reliable tool for imaging selection in patients with acute ischemic stroke and its interrater reliability and ability to help determine clinical outcome are demonstrated.
Journal ArticleDOI
The appropriate and justified use of medical radiation in cardiovascular imaging: a position document of the ESC Associations of Cardiovascular Imaging, Percutaneous Cardiovascular Interventions and Electrophysiology
Eugenio Picano,Eliseo Vano,Eliseo Vano,Madan M. Rehani,Alberto Cuocolo,Lluís Mont,Vicente Bodi,Olivier Bar,Carlo Maccia,Luc Pierard,Rosa Sicari,Sven Plein,Heiko Mahrholdt,Patrizio Lancellotti,Juhani Knuuti,Hein Heidbuchel,Carlo Di Mario,Luigi P. Badano +17 more
TL;DR: A European perspective on the best way to play an active role in implementing into clinical practice the key principle of radiation protection that: 'each patient should get the right imaging exam, at the right time, with the right radiation dose'.
Journal ArticleDOI
Practical ways to reduce radiation dose for patients and staff during device implantations and electrophysiological procedures
Hein Heidbuchel,Fred H.M. Wittkampf,Eliseo Vano,Sabine Ernst,Richard J. Schilling,Eugenio Picano,Lluís Mont,Pierre Jaïs,Joseph de Bono,Christopher Piorkowski,EB Saad,Francisco Femenía +11 more
TL;DR: This position paper wants to offer some very practical advice on how to reduce exposure to patients and staff, and describes how customization of the X-ray system, workflow adaptations, and shielding measures can be implemented in the cath lab.
Journal ArticleDOI
Space radiation risks to the central nervous system
TL;DR: Recent space radiobiology studies of CNS effects from particle accelerators simulating space radiation using experimental models are summarized, and a critical assessment of their relevance relative to doses and dose-rates to be incurred on a Mars mission is made.
References
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Journal ArticleDOI
Elemental diet as an adjuvant for patients with locally advanced gastrointestinal cancer receiving radiation therapy: a prospectively randomized study.
Harold O. Douglass,Suzanne Milliron,Hector R. Nava,Bengt Eriksson,Patrick Thomas,Anne Novick,E. Douglas Holyoke +6 more
TL;DR: Although weight loss associated with radiation therapy was not significantly reduced in those receiving the nutritional supplement, delayed hypersensitivity skin test responses tended to improve in patients receiving the elemental dietary supplement and to deteriorate in controls.
Journal ArticleDOI
Immune effects of low-dose radiation: short-term induction of thymocyte apoptosis and long-term augmentation of T-cell-dependent immune responses.
TL;DR: The results emphasize the existence of a lag time between the time of low-dose irradiation in vivo and the appearance of radioresistance and a mechanism that interconnects an environmental stimulus with the response of the animal is proposed based on the evidence presented here and reported in the literature.
Journal ArticleDOI
Radiation tolerance of the skin.
TL;DR: In this paper, the authors discuss the radiation tolerance of the skin and its effect on its ability to tolerate radiation in terms of the amount of radiation required to be inhaled and inhaled.
Journal ArticleDOI
Long-term prognosis of patients with severe radiation enteritis
Henrik Harling,Ib Balslev +1 more
TL;DR: Life expectancy was poorer in patients presenting with perforation or fistula compared with bleeding or stricture, the main reason being significantly more recurrences among patients with fistulas.
Journal ArticleDOI
PIBI(D)S syndrome—trichothiodystrophy with xeroderma pigmento sum (group D) mutation
Alfredo Rebora,Franco Crovato +1 more
TL;DR: An autosomal recessive syndrome was described in this article that associates extreme photosensitivity with a defect of the deoxyribonucleic acid (DNA) excision repair system, mild noncongenital ichthyosis, brittle cystine-deficient hair, impaired intelligence, neurologic disorders, and short stature.