Journal ArticleDOI
Identification of Native American Founder mtDNAs Through the Analysis of Complete mtDNA Sequences: Some Caveats
Hans-Jürgen Bandelt,Corinna Herrnstadt,Yong-Gang Yao,Qing-Peng Kong,Toomas Kivisild,Toomas Kivisild,Chiara Rengo,Rosaria Scozzari,Martin B. Richards,Richard Villems,Vincent Macaulay,Neil Howell,Antonio Torroni,Ya-Ping Zhang +13 more
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TLDR
A careful analysis of all available data indicates that there is very little evidence that more than five founder mtDNA sequences entered Beringia before the Last Glacial Maximum and left their traces in the current Native American mtDNA pool.Abstract:
In this study, a detailed analysis of both previously published and new data was performed to determine whether complete, or almost complete, mtDNA sequences can resolve the long-debated issue of which Asian mtDNAs were founder sequences for the Native American mtDNA pool. Unfortunately, we now know that coding region data and their analysis are not without problems. To obtain and report reasonably correct sequences does not seem to be a trivial task, and to discriminate between Asian and Native American mtDNA ancestries may be more complex than previously believed. It is essential to take into account the effects of mutational hot spots in both the control and coding regions, so that the number of apparent Native American mtDNA founder sequences is not erroneously inflated. As we report here, a careful analysis of all available data indicates that there is very little evidence that more than five founder mtDNA sequences entered Beringia before the Last Glacial Maximum and left their traces in the current Native American mtDNA pool.read more
Citations
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Journal ArticleDOI
Distinctive Paleo-Indian Migration Routes from Beringia Marked by Two Rare mtDNA Haplogroups
Ugo A. Perego,Ugo A. Perego,Alessandro Achilli,Alessandro Achilli,Norman Angerhofer,Matteo Accetturo,Maria Pala,Anna Olivieri,Baharak Hooshiar Kashani,Kathleen H. Ritchie,Rosaria Scozzari,Qing-Peng Kong,Qing-Peng Kong,Natalie M. Myres,Antonio Salas,Ornella Semino,Hans-Jürgen Bandelt,Scott R. Woodward,Antonio Torroni +18 more
TL;DR: A dual origin for the first Americans is a striking novelty from the genetic point of view, and it makes plausible a scenario positing that within a rather short period of time, there may have been several entries into the Americas from a dynamically changing Beringian source.
Journal ArticleDOI
Beringian standstill and spread of Native American founders.
Erika Tamm,Toomas Kivisild,Toomas Kivisild,Maere Reidla,Mait Metspalu,David Glenn Smith,Connie J. Mulligan,Claudio M. Bravi,Olga Rickards,Cristina Martínez-Labarga,E. K. Khusnutdinova,S. A. Fedorova,S. A. Fedorova,M. V. Golubenko,M. V. Golubenko,Vadim Stepanov,Marina Gubina,Marina Gubina,Sergey I. Zhadanov,Sergey I. Zhadanov,Sergey I. Zhadanov,Ludmila P. Ossipova,Larisa Damba,Larisa Damba,Mikhail Voevoda,José E. Dipierri,Richard Villems,Ripan S. Malhi +27 more
TL;DR: The newly resolved phylogenetic structure suggests that ancestors of Native Americans paused when they reached Beringia, during which time New World founder lineages differentiated from their Asian sister-clades, and a swift migration southward that distributed the founder types all the way to South America.
Journal ArticleDOI
Mitochondrial population genomics supports a single pre-Clovis origin with a coastal route for the peopling of the Americas.
Nelson J. R. Fagundes,Ricardo Kanitz,Roberta Eckert,Ana Carolina Silva e Valls,Maurício Reis Bogo,Francisco M. Salzano,David Glenn Smith,Wilson A. Silva,Marco Antônio Zago,Andrea Ribeiro-dos-Santos,Sidney Santos,Maria Luiza Petzl-Erler,Sandro L. Bonatto +12 more
TL;DR: It is shown, by using 86 complete mitochondrial genomes, that all Native American haplogroups, including haplogroup X, were part of a single founding population, thereby refuting multiple-migration models and supporting a pre-Clovis occupation of the New World.
Journal ArticleDOI
Phylogeny of East Asian Mitochondrial DNA Lineages Inferred from Complete Sequences
Qing-Peng Kong,Yong-Gang Yao,Yong-Gang Yao,Chang Sun,Chang Sun,Hans-Jürgen Bandelt,Chun-Ling Zhu,Ya-Ping Zhang,Ya-Ping Zhang +8 more
TL;DR: This East Asian mtDNA phylogeny can henceforth serve as a solid basis for phylogeographic analyses of mtDNAs, as well as for studies of mitochondrial diseases in East and Southeast Asia.
Journal ArticleDOI
The phylogeny of the four pan-American MtDNA haplogroups: implications for evolutionary and disease studies.
Alessandro Achilli,Alessandro Achilli,Ugo A. Perego,Ugo A. Perego,Claudio M. Bravi,Michael D. Coble,Qing-Peng Kong,Qing-Peng Kong,Scott R. Woodward,Antonio Salas,Antonio Torroni,Hans-Jürgen Bandelt +11 more
TL;DR: A human entry and spread of the pan-American haplogroups into the Americas right after the peak of the Last Glacial Maximum is indicated and comfortably agrees with the undisputed ages of the earliest Paleoindians in South America.
References
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Dan Mishmar,Eduardo Ruiz-Pesini,Pawel Golik,Vincent Macaulay,Andrew G. Clark,S.H. Hosseini,Martin Brandon,Kirk A. Easley,Estella B. Chen,Michael D. Brown,Rem I. Sukernik,Antonel Olckers,Douglas C. Wallace +12 more
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