Impact of obesity on infertility in women.
Zeynep Ozcan Dag,Berna Dilbaz +1 more
TLDR
Overweight women have a higher incidence of menstrual dysfunction and anovulation, and are at a high risk for reproductive health, and weight loss has beneficial effects on the reproductive outcomes in patients.Abstract:
The prevalence of obesity and overweight are increasing and have become an epidemic worldwide. Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility. The relationship between obesity and reproductive functions is still being explored. Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at a high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women. They have poor reproductive outcomes in natural as well as assisted conception. These poor reproductive outcomes include assisted reproduction such as ovulation induction, in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), and ovum donation cycles. Weight loss has beneficial effects on the reproductive outcomes in these patients.read more
Citations
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Journal ArticleDOI
Obesity Modulates Inflammation and Lipid Metabolism Oocyte Gene Expression: A Single-Cell Transcriptome Perspective.
Meghan L. Ruebel,Matthew Cotter,Clark R. Sims,Dean M. Moutos,Thomas M. Badger,Mario A. Cleves,Kartik Shankar,Aline Andres +7 more
TL;DR: Findings provide evidence for the significant influence of body composition on oocyte transcript abundance in women undergoing hormonal induction to retrieve oocytes and identify the potential for maternal diet to influence oocyte gene expression.
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An internet-based prospective study of body size and time to pregnancy
Lauren A. Wise,Kenneth J. Rothman,Kenneth J. Rothman,Ellen M. Mikkelsen,Henrik Toft Sørensen,Henrik Toft Sørensen,Anders H. Riis,Elizabeth E. Hatch +7 more
TL;DR: In this article, the authors examined the association between anthropometric factors and TTP among I65I Danish women participating in an inter-net-based prospective cohort study of pregnancy planners (2007―2008).
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Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity
TL;DR: The data suggest that male obesity negatively impacts on male reproductive potential, not only through altering hormone levels, but also by directly altering sperm function.
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Environment, Lifestyle, and Female Infertility
TL;DR: This review aims to dissect the plausible interconnection of lifestyle and environmental factors with various neuroendocrine pathways and to discuss how it can affect the female physiology in the long-term, resulting in reproductive incompetence.
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Nutrition in Pregnancy Following Bariatric Surgery
TL;DR: It is advisable to delay pregnancy for at least 12 months following bariatric surgery and a multidisciplinary approach to care is desirable with close monitoring for deficiencies at each trimester.
References
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Effect of increased body mass index on oocyte and embryo quality in IVF patients.
TL;DR: It is concluded that obesity may adversely affect embryo quality in young women (<35 years) undergoing IVF/ICSI, while the oocyte quality is not affected.
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Extremes of body mass do not adversely affect the outcome of superovulation and in-vitro fertilization.
TL;DR: The extremes of body mass index do not adversely affect the outcome of IVF-embryo transfer treatment, however, the obese patients had lower peak oestradiol concentrations than their normal controls despite receiving similar gonadotrophin doses.
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Distribution and characterization of insulin and insulin-like growth factor I receptors in normal human ovary.
TL;DR: It is concluded that specific high affinity insulin receptors possessing tyrosine kinase activity are widely distributed in normal human ovary, and IGF-I receptors in normal ovary are either absent or present at very low density.
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The impact of obesity and insulin resistance on the outcome of IVF or ICSI in women with polycystic ovarian syndrome
TL;DR: It is concluded that in PCOS women receiving long-term down-regulation and stimulation with recombinant FSH, insulin resistance is neither related to hormone levels nor to IVF outcome, and obesity, independent of insulin resistance, is associated with relative gonadotrophin resistance.
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Transition from overweight to obesity worsens pregnancy outcome in a BMI-dependent manner.
TL;DR: Objective: To assess pregnancy outcomes in different BMI groups by evaluating the impact of diet and exercise on weight during the first trimester of pregnancy.