Impact of obesity on infertility in women.
Zeynep Ozcan Dag,Berna Dilbaz +1 more
TLDR
Overweight women have a higher incidence of menstrual dysfunction and anovulation, and are at a high risk for reproductive health, and weight loss has beneficial effects on the reproductive outcomes in patients.Abstract:
The prevalence of obesity and overweight are increasing and have become an epidemic worldwide. Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility. The relationship between obesity and reproductive functions is still being explored. Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at a high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women. They have poor reproductive outcomes in natural as well as assisted conception. These poor reproductive outcomes include assisted reproduction such as ovulation induction, in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), and ovum donation cycles. Weight loss has beneficial effects on the reproductive outcomes in these patients.read more
Citations
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Obesity Modulates Inflammation and Lipid Metabolism Oocyte Gene Expression: A Single-Cell Transcriptome Perspective.
Meghan L. Ruebel,Matthew Cotter,Clark R. Sims,Dean M. Moutos,Thomas M. Badger,Mario A. Cleves,Kartik Shankar,Aline Andres +7 more
TL;DR: Findings provide evidence for the significant influence of body composition on oocyte transcript abundance in women undergoing hormonal induction to retrieve oocytes and identify the potential for maternal diet to influence oocyte gene expression.
Journal ArticleDOI
An internet-based prospective study of body size and time to pregnancy
Lauren A. Wise,Kenneth J. Rothman,Kenneth J. Rothman,Ellen M. Mikkelsen,Henrik Toft Sørensen,Henrik Toft Sørensen,Anders H. Riis,Elizabeth E. Hatch +7 more
TL;DR: In this article, the authors examined the association between anthropometric factors and TTP among I65I Danish women participating in an inter-net-based prospective cohort study of pregnancy planners (2007―2008).
Journal ArticleDOI
Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity
TL;DR: The data suggest that male obesity negatively impacts on male reproductive potential, not only through altering hormone levels, but also by directly altering sperm function.
Journal ArticleDOI
Environment, Lifestyle, and Female Infertility
TL;DR: This review aims to dissect the plausible interconnection of lifestyle and environmental factors with various neuroendocrine pathways and to discuss how it can affect the female physiology in the long-term, resulting in reproductive incompetence.
Journal ArticleDOI
Nutrition in Pregnancy Following Bariatric Surgery
TL;DR: It is advisable to delay pregnancy for at least 12 months following bariatric surgery and a multidisciplinary approach to care is desirable with close monitoring for deficiencies at each trimester.
References
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Journal ArticleDOI
Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women
Jan Willem van der Steeg,Jan Willem van der Steeg,Jan Willem van der Steeg,Pieternel Steures,Pieternel Steures,Pieternel Steures,Marinus J.C. Eijkemans,J. Dik F. Habbema,Peter G.A. Hompes,Jan M. Burggraaff,G. Jur E. Oosterhuis,Patrick M.M. Bossuyt,Fulco van der Veen,Ben W.J. Mol +13 more
TL;DR: Obesity is associated with lower pregnancy rates in subfertile ovulatory women, and women with a high BMI had a 4% lower pregnancy rate per kg/m(2) increase.
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Subfecundity in overweight and obese couples
Cecilia Høst Ramlau-Hansen,Ane Marie Thulstrup,Ellen A. Nohr,Jens Peter Bonde,Thorkild I. A. Sørensen,Jørn Olsen +5 more
TL;DR: Couples have a high risk of being subfecund if they are both obese and this work found a dose-response relationship between increasing BMI group and subFecundity (a TTP of more than 12 months).
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Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries.
TL;DR: This is the first report of a difference in thecal androgen production between normal and polycystic ovaries and supports the hypothesis that there is a primary abnormality in the regulation of androgens production in PCOS.
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Current concepts of the roles of follicle stimulating hormone and luteinizing hormone in folliculogenesis
TL;DR: The development-related response to LH shown by the pre-ovulatory follicle raises the possibility that exogenous LH might be used as an adjunct to therapy with exogenous FSH in clinical ovulation induction regimens where the aim is to induce monovulation.
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Obesity and time to pregnancy
D.C. Gesink Law,D.C. Gesink Law,Richard F. MacLehose,Matthew P. Longnecker,Matthew P. Longnecker +4 more
TL;DR: The results suggest that weight loss could increase fecundity for overweight and obese women, regardless of menstrual cycle regularity, parity, smoking habits and age.