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Impact of obesity on infertility in women.

TLDR
Overweight women have a higher incidence of menstrual dysfunction and anovulation, and are at a high risk for reproductive health, and weight loss has beneficial effects on the reproductive outcomes in patients.
Abstract
The prevalence of obesity and overweight are increasing and have become an epidemic worldwide. Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility. The relationship between obesity and reproductive functions is still being explored. Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at a high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women. They have poor reproductive outcomes in natural as well as assisted conception. These poor reproductive outcomes include assisted reproduction such as ovulation induction, in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), and ovum donation cycles. Weight loss has beneficial effects on the reproductive outcomes in these patients.

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Citations
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Journal ArticleDOI

Maternal obesity and ovarian failure: is leptin the culprit?

TL;DR: In this paper , the role of leptin in the metabolic dysregulation within the follicle, the effects on the oocyte epigenome, and the potential long-term consequence to embryo programming is discussed.
Journal ArticleDOI

How obesity affects female fertility

TL;DR: Treatment of obesity, particularly abdominal obesity treatment, is linked to improved reproductive function thus treating obesity must be the first priority in infertile obese women before considering drugs of ovulation induction or procedures of assisted reproduction.
Journal ArticleDOI

Protective effect of Salvia hispanica (chia seeds) against obesity induced ovarian disorders in rat model.

TL;DR: In this paper , the effects of chia seeds against obesity-induced ovarian dysfunctions with a trial to elucidate the mechanism of action were evaluated. But, the main goal of the study was to assess the protective impacts of chias seeds against ovarian dysfunction.
References
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Journal ArticleDOI

The hormone resistin links obesity to diabetes

TL;DR: It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.
Journal ArticleDOI

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

TL;DR: The pathophysiology of adiponectin and adiponECTin receptors in insulin resistance, diabetes, and the metabolic syndrome is described and potential versatile therapeutic targets to combat obesity-linked diseases characterized by insulin resistance are described.
Journal ArticleDOI

Adiponectin and Adiponectin Receptors

TL;DR: It is shown that AdipoR1 and AdIPoR2 serve as receptors for globular and full-length adiponectin and mediate increased AMP-activated protein kinase, peroxisome proliferator-activated receptor-alpha ligand activities, and glucose uptake and fatty-acid oxidation by adiponECTin.
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Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment.

TL;DR: Weight loss should be considered as a first option for women who are infertile and overweight, and the cost savings of the programme were considerable.
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