Impact of obesity on infertility in women.
Zeynep Ozcan Dag,Berna Dilbaz +1 more
TLDR
Overweight women have a higher incidence of menstrual dysfunction and anovulation, and are at a high risk for reproductive health, and weight loss has beneficial effects on the reproductive outcomes in patients.Abstract:
The prevalence of obesity and overweight are increasing and have become an epidemic worldwide. Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility. The relationship between obesity and reproductive functions is still being explored. Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at a high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women. They have poor reproductive outcomes in natural as well as assisted conception. These poor reproductive outcomes include assisted reproduction such as ovulation induction, in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), and ovum donation cycles. Weight loss has beneficial effects on the reproductive outcomes in these patients.read more
Citations
More filters
Journal ArticleDOI
Hormonal and biochemical study of the effect of obesity on women infertility
TL;DR: The study showed that obesity is a new indicator of increasing the infertility risk for women of all ages through BMI and WHR, whereas an unwanted correlation with HDL was noted.
Journal ArticleDOI
Ernährung bei Kinderwunsch: Stand der Evidenz und Empfehlungen
TL;DR: In this paper , eine ausreichende Zufuhr kritischer Nährstoffe sicherzustellen und bestehende Defizite gezielt auszugleichen.
Journal ArticleDOI
The Impact of Bariatric Surgery on Assisted Reproductive Technology Outcomes: A Systematic Review.
TL;DR: In this article , a systematic review aimed to determine if bariatric surgery impacts ART outcomes and if effects vary between females and males, concluding that high-quality research is needed to delineate the direct effects of bariatric operations on ART outcomes.
Journal ArticleDOI
Obesity is associated with alterations in antral follicle dynamics in eumenorrheic women.
TL;DR: A longitudinal study of 42 women conducted over one interovulatory interval (IOI) showed that women with obesity display evidence of suppressed antral follicle dynamics as judged by fewer recruitment events, selectable follicles and anovulatory dominant follicles, as well as lower anti-Müllerian hormone (AMH) concentrations and an increased prevalence of luteal phase defects as discussed by the authors .
References
More filters
Journal ArticleDOI
The hormone resistin links obesity to diabetes
Claire M. Steppan,Shannon T. Bailey,Savitha Bhat,Elizabeth J. Brown,Ronadip R. Banerjee,Christopher M. Wright,Hiralben R. Patel,Rexford S. Ahima,Mitchell A. Lazar +8 more
TL;DR: It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.
Journal ArticleDOI
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
TL;DR: The pathophysiology of adiponectin and adiponECTin receptors in insulin resistance, diabetes, and the metabolic syndrome is described and potential versatile therapeutic targets to combat obesity-linked diseases characterized by insulin resistance are described.
Journal ArticleDOI
Adiponectin and Adiponectin Receptors
TL;DR: It is shown that AdipoR1 and AdIPoR2 serve as receptors for globular and full-length adiponectin and mediate increased AMP-activated protein kinase, peroxisome proliferator-activated receptor-alpha ligand activities, and glucose uptake and fatty-acid oxidation by adiponECTin.
Journal ArticleDOI
Visfatin : A protein secreted by visceral fat that mimics the effects of insulin
Atsunori Fukuhara,Morihiro Matsuda,Masako Nishizawa,Katsumori Segawa,Masaki Tanaka,Kae Kishimoto,Yasushi Matsuki,Mirei Murakami,Tomoko Ichisaka,Hiroko Murakami,Eijoro Watanabe,Toshiyuki Takagi,Megumi Akiyoshi,Tsuguteru Ohtsubo,Shinji Kiliara,Shizuya Yamashita,Makoto Makishima,Tohru Funahashi,Shinya Yamanaka,Ryuji Hiramatsu,Yuji Matsuzawa,Iichiro Shimomura +21 more
TL;DR: A newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans and mice and whose expression level in plasma increases during the development of obesity is isolated.
Journal ArticleDOI
Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment.
TL;DR: Weight loss should be considered as a first option for women who are infertile and overweight, and the cost savings of the programme were considerable.