Impact of obesity on infertility in women.
Zeynep Ozcan Dag,Berna Dilbaz +1 more
TLDR
Overweight women have a higher incidence of menstrual dysfunction and anovulation, and are at a high risk for reproductive health, and weight loss has beneficial effects on the reproductive outcomes in patients.Abstract:
The prevalence of obesity and overweight are increasing and have become an epidemic worldwide. Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility. The relationship between obesity and reproductive functions is still being explored. Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at a high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women. They have poor reproductive outcomes in natural as well as assisted conception. These poor reproductive outcomes include assisted reproduction such as ovulation induction, in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), and ovum donation cycles. Weight loss has beneficial effects on the reproductive outcomes in these patients.read more
Citations
More filters
Journal ArticleDOI
Obesity Modulates Inflammation and Lipid Metabolism Oocyte Gene Expression: A Single-Cell Transcriptome Perspective.
Meghan L. Ruebel,Matthew Cotter,Clark R. Sims,Dean M. Moutos,Thomas M. Badger,Mario A. Cleves,Kartik Shankar,Aline Andres +7 more
TL;DR: Findings provide evidence for the significant influence of body composition on oocyte transcript abundance in women undergoing hormonal induction to retrieve oocytes and identify the potential for maternal diet to influence oocyte gene expression.
Journal ArticleDOI
An internet-based prospective study of body size and time to pregnancy
Lauren A. Wise,Kenneth J. Rothman,Kenneth J. Rothman,Ellen M. Mikkelsen,Henrik Toft Sørensen,Henrik Toft Sørensen,Anders H. Riis,Elizabeth E. Hatch +7 more
TL;DR: In this article, the authors examined the association between anthropometric factors and TTP among I65I Danish women participating in an inter-net-based prospective cohort study of pregnancy planners (2007―2008).
Journal ArticleDOI
Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity
TL;DR: The data suggest that male obesity negatively impacts on male reproductive potential, not only through altering hormone levels, but also by directly altering sperm function.
Journal ArticleDOI
Environment, Lifestyle, and Female Infertility
TL;DR: This review aims to dissect the plausible interconnection of lifestyle and environmental factors with various neuroendocrine pathways and to discuss how it can affect the female physiology in the long-term, resulting in reproductive incompetence.
Journal ArticleDOI
Nutrition in Pregnancy Following Bariatric Surgery
TL;DR: It is advisable to delay pregnancy for at least 12 months following bariatric surgery and a multidisciplinary approach to care is desirable with close monitoring for deficiencies at each trimester.
References
More filters
Journal ArticleDOI
Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome
TL;DR: It is confirmed that metformin treatment can lead to improvements in insulin resistance and ovarian hyperandrogenism.
Journal ArticleDOI
Female obesity impairs in vitro fertilization outcome without affecting embryo quality.
José Bellver,Yanira Ayllón,Marcos Ferrando,M.A.B. Melo,Eduardo Goyri,Antonio Pellicer,José Remohí,Marcos Meseguer +7 more
TL;DR: Female obesity impairs IVF outcome, but embryo quality is not affected, pointing to an alteration in the uterine environment.
Journal ArticleDOI
Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary.
TL;DR: It is demonstrated that leptin can directly inhibit IGF-I action in ovarian theca and GC at concentrations commonly present in obese women.
Journal ArticleDOI
Body mass index and ovulatory infertility.
TL;DR: It is concluded that the risk of ovulatory infertility is highest in obese women but is also slightly increased in moderately overweight and underweight women.
Journal ArticleDOI
Effects of obesity on women's reproduction and complications during pregnancy.
TL;DR: The aim of this article is to review the consequences of being obese during the reproductive life of a woman and to highlight the risks to women in fertile ages who are obese.