Impact of obesity on infertility in women.
Zeynep Ozcan Dag,Berna Dilbaz +1 more
TLDR
Overweight women have a higher incidence of menstrual dysfunction and anovulation, and are at a high risk for reproductive health, and weight loss has beneficial effects on the reproductive outcomes in patients.Abstract:
The prevalence of obesity and overweight are increasing and have become an epidemic worldwide. Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility. The relationship between obesity and reproductive functions is still being explored. Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at a high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women. They have poor reproductive outcomes in natural as well as assisted conception. These poor reproductive outcomes include assisted reproduction such as ovulation induction, in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), and ovum donation cycles. Weight loss has beneficial effects on the reproductive outcomes in these patients.read more
Citations
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Journal ArticleDOI
Biochemical Changes in Female Infertility: Highlights on Leptin, Adiponectin, Visfatin, and Resistin
TL;DR: Sex hormones have influence on adipokines indicating role of adipokine in infertility, and BMI, waist/hip ratio, insulin, insulin resistance was significantly high in cases than controls.
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Correlation of prolactin with thyroid-stimulating hormone and female sex hormones in infertile women.
Journal ArticleDOI
Патогенетические аспекты метаболического синдрома у женщин репродуктивного возраста (обзор литературы)
TL;DR: Hyperandrogenism, insulin resistance, obesity, diabetes 2 type, dyslipidemia, PCOS are shown to be the most signifi cant factors determining pathological changes in fertile age women with metabolic syndrome, and correction of these factors should be included in the course of pregravid preparation for the prevention of adverse pregnancy outcomes.
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High-fat diet induced obesity alters Dnmt1 and Dnmt3a levels and global DNA methylation in mouse ovary and testis
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Contribution of Modifiable Risk Factors on the Burden of Diabetes Among Women in Reproductive Age-Group in India: A Population Based Cross-Sectional Study
TL;DR: Overweight, Obesity and Hypertension were important contributors to the diabetes burden, which if mitigated optimally can reduce diabetic cases by 1.6 million, 1.5 million, and 1.3 million, respectively.
References
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TL;DR: It is shown that AdipoR1 and AdIPoR2 serve as receptors for globular and full-length adiponectin and mediate increased AMP-activated protein kinase, peroxisome proliferator-activated receptor-alpha ligand activities, and glucose uptake and fatty-acid oxidation by adiponECTin.
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Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment.
TL;DR: Weight loss should be considered as a first option for women who are infertile and overweight, and the cost savings of the programme were considerable.