Impact of obesity on infertility in women.
Zeynep Ozcan Dag,Berna Dilbaz +1 more
TLDR
Overweight women have a higher incidence of menstrual dysfunction and anovulation, and are at a high risk for reproductive health, and weight loss has beneficial effects on the reproductive outcomes in patients.Abstract:
The prevalence of obesity and overweight are increasing and have become an epidemic worldwide. Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility. The relationship between obesity and reproductive functions is still being explored. Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at a high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women. They have poor reproductive outcomes in natural as well as assisted conception. These poor reproductive outcomes include assisted reproduction such as ovulation induction, in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), and ovum donation cycles. Weight loss has beneficial effects on the reproductive outcomes in these patients.read more
Citations
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Role of Adiponectin and Insulin resistance in Android and Gynoid obese infertile women
TL;DR: Adiponectin levels are found to be decreased in obese infertile females due to visceral adiposity that results in insulin resistance, and life style modifications benefit the overweight infertiles women that modulate in reducing the visceral fat mass and thereby increase adiponECTin levels.
Journal ArticleDOI
Expert consensus for primary management of reproductive health: a Delphi study
Andrea Bernabeu,Concepción Carratalá-Munuera,Jose A. Quesada,Joaquín Llácer,Adriana Lopez-Pineda,Francisco Sellers,Vicente Francisco Gil-Guillén,Rafael Bernabeu,Kamila Cheikh-Moussa,Domingo Orozco-Beltrán +9 more
TL;DR: These recommendations could set the basis for a public health action plan for primary management of reproductive health in Spain and may be applicable to any country whose health services system provides primary healthcare.
Posted ContentDOI
Leptin resistance establishment in the ovary of diet-induced obese mice and its relationship with cumulus cells transcriptome
Karolina Wołodko,Edyta Walewska,Juan Castillo-Fernandez,Gavin Kelsey,Gavin Kelsey,António Galvão,António Galvão +6 more
TL;DR: It is discovered that obesity leads to ovarian leptin resistance after 16wk high-fat diet (HFD), as evidenced by increases in SOCS3 and decreases in pJAK2 and ObRb-pTyr985.
Journal ArticleDOI
The role of socio-economic status and energy-density in Australian women of child-bearing age.
R. Latter,R. Latter,Leanne Brown,Leanne Brown,Kym Rae,Megan E. Rollo,Megan E. Rollo,Tracy L. Schumacher +7 more
TL;DR: It is suggested that a large proportion of women, who may become pregnant, have diets that exceed the international recommendations for dietary energy density, and this may be influenced by socio-economic status (SES).
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Maternal obesity and ovarian failure: is leptin the culprit?
TL;DR: The role of leptin in the metabolic dysregulation within the follicle, the effects on the oocyte epigenome, and the potential long-term consequence to embryo programming is discussed in this article .
References
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Journal ArticleDOI
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TL;DR: It is shown that AdipoR1 and AdIPoR2 serve as receptors for globular and full-length adiponectin and mediate increased AMP-activated protein kinase, peroxisome proliferator-activated receptor-alpha ligand activities, and glucose uptake and fatty-acid oxidation by adiponECTin.
Journal ArticleDOI
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Journal ArticleDOI
Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment.
TL;DR: Weight loss should be considered as a first option for women who are infertile and overweight, and the cost savings of the programme were considerable.